摘要：Urgent requirements of medical devices Precision medicine has gradually become a development strategy in many countries and attracted worldwide attention in recent years due to the increasing concerns in public *** the definition of precision medicine has less or more difference from the viewpoints of different fields,the demands on the properties of medical devices or medical materials involving biocompatibility and anti-thrombosis are gradually growingmuch more diverse and much more urgent than ever[1].This trend brings up many new research topics about materials,mechanical systems and sensors to develop advanced medical *** to design and on-demand fabricate the bio-materials,bio-interface and bio-systems to meet the urgent demands of medical devices is still a challenge for us.

摘要：A campus bus network design and evaluation, taking Tsinghua University as an example, is investigated in this paper. To minimize the total cost for both passengers and operator, the campus bus system planning in a sequential approach is discussed, including the route network design, headway （i.e., the inverse of service frequency） optimization, and system evaluation. The improved genetic algorithm is proposed to optimize the route network based on the route property, and the impacts of the fluctuation of passenger demand and average traveling time are analyzed. The identity proportion in the headway optimization is then introduced with full consideration of its impacts. Based on the actual variety of passenger demand, a non-fixed schedule demonstrates its efficiency. VISSIM is finally adopted to simulate the campus bus system and a comprehensive evaluation system for the campus bus is developed. Compared with the current bus network and the one without considering the route property, the evaluation of the proposed approach shows an improvement of 18.7% and 10.1%, respectively. Moreover, the sequential approach shows an efficiency significance for the development of public transit systems passengers and operator. mprovement over the alternative method. It is of great n large industrial parks to decrease the total cost for both

摘要：Tissue engineering has been striving toward designing and producing natural and functional human *** are the fundamental building blocks of *** with traditional two-dimensional cultured cells,cell spheres are threedimensional(3D)structures that can naturally form complex cell–cell and cell–matrix *** structure is close to the natural environment of cells in living *** addition to being used in disease modeling and drug screening,spheroids have significant potential in tissue *** 3D bioprinting is an advanced biofabrication *** accurately deposits bioinks into predesigned 3D shapes to create complex tissue *** 3D bioprinting is efficient,the time required for cells to develop into complex tissue structures can be *** 3D bioprinting of spheroids significantly reduces the time required for their development into large tissues/organs during later cultivation stages by printing them with high cell *** spheroid fabrication and bioprinting technology should provide a new solution to many problems in regenerative *** paper systematically elaborates and analyzes the spheroid fabrication methods and 3D bioprinting strategies by introducing spheroids as building ***,we present the primary challenges faced by spheroid fabrication and 3D bioprinting with future requirements and some recommendations.

摘要：In this paper, the problems of chaos and chaos control for a class of susceptible-infected- removed （SIR） epidemic model with seasonal fluctuation are investigated. The season- ality in outbreak is natural among infectious diseases, as the common influenza, A type H1N1 influenza and so on. It is shown that there exist chaotic phenomena in the epidemic model. Furthermore, the tracking control method is used to control chaotic motions in the epidemic model. A feedback controller is designed to achieve tracking of an ideal out- put. Thus, the density of infected individuals can converge to zero, in other words, thedisease can be disappeared. Finally, numerical simulations illustrate that the controller is effective.

摘要：This paper proposes a novel underactuated finger mechanism based on a motion coupling and shape-adaptive linkage design that combines anthropomorphic free motion and adaptive grasping. The proposed three-joint finger mechanism with one active Degree of Freedom （DOF） consists of a five-linkage meehanism in the proximal phalanx and a mechanism comprising two parallel planar four-bar linkages in the middle phalanx. The respective mechanism allows the simultaneously rotation of their corresponding pha- langes in the plane before making contact with an object, and can fully envelop an object, even if certain phalanges are blocked. The duel parallel four-bar linkage mechanism is adopted to improve the grasping capacity of the distal phalanx. An optimal design of the finger is presented according to anthropomorphic phalanx trajectories and maximized grasping forces obtained with consideration for the angular velocity relationships of the three phalanges and their force transmission performances. The functionality of the proposed finger mechanism is verified through multiple simulations and grasping experiments using a prototype finger.

摘要：T-cell receptor （TCR）-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR- engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR- engineered T cells to target New York esophageal squamous cell carcinoma （NY-ESO-1）. These successes demonstrate the potential of this approach to treat cancer. In this review, we provide a perspective on the current and future applications of TCR-engineered T cells for the treatment of cancer. Our summary focuses on TCR activation and both pre-clinical and clinical applications of TCR-engineered T cells. We also discuss how to enhance the function of TCR-engineered T cells and prolong their longevity in the tumor microenvironment.

摘要：花瑶挑花纹样造型多样、设计精巧,具有较高的美学价值与应用价值,但将其创新应用至箱包设计领域的相关研究却相对较少。从设计学角度出发,分析花瑶挑花的典型图案和文化内涵,归纳其核心元素特征;调查研析消费人群及其风格偏好,确立产品的设计定位;选取典型挑花纹样,运用形状文法和风格迁移算法分别进行创新再造设计,并结合3D数字化软件将创新方案应用于时尚女包设计中,开发出兼具民族特色和现代形式美感的革制品。通过将数字化技术手段与花瑶挑花纹样皮具的有机结合,既保证了挑花纹样的迭代与创新,又提高了革制品图案设计的创作效率。

摘要：Long-term air contamination and pollution challenges in particulate matter(PM) have raised fervent concerns for public health, e.g., the PM physical damage or the bacteria and virus carried by the PM. The desired air filter, seeking both high filtration efficiency and low pressure drop remains challenging. Here, we report a bio-inspired spindle-knot halloysite nanotube microsphere-incorporated nanofiber(HNM-NF) filter with the assembly and shape structures of the spider silk. The resulting HNM-NFs exhibit integrated properties of high surface energy, hydrophilicity and strong PM capture. The spindle-knot structures could shrink the outer pore size on two-dimensional(2 D) surface and construct the fluffy 3 D reticular architecture, facilitating high-efficiency air pollutant capture(>85.0%) while maintaining low resistance to airflow(~39 Pa). The spindle-knot construction method was applicable to various materials(i.e.,Al_(2)O_(3), ZnO and TiO_(2)) and volume production of the microsphere-incorporated NF cartridge. The diversified spindleknot construction will be valuable for adapting to meet different filtration requirements.

摘要：为促进江南丝竹在数字化时代的活态传承与发展,文章以文化体验相关理念为基础,探究江南丝竹AR交互设计的创新方法。通过分析AR交互设计在非遗类应用中的设计实践现状,从文化体验感官层面、交互层面、情感层面三个维度提出了江南丝竹AR交互设计思路,并通过实践验证了该思路在江南丝竹AR交互设计中的可行性。以期为用户提供沉浸式体验与学习江南丝竹的平台,为非物质文化遗产传承提供更多方向和可能性。

摘要：目的:废旧轮胎正成为一个日益严峻的环境问题。本文旨在研究发掘一个高效绿色的处理废旧轮胎的方法。本文探讨微波热解废旧轮胎的可能性,同时研究不同环境温度、微波频率以及样本大小对微波热解废旧轮胎效率的影响。方法:1.通过实验分析,验证影响微波热解废旧轮胎的关键因素,同时找出微波热解废旧轮胎的最佳条件。2.理论设计多个与分解效率相关的变量,推导其计算公式,从而证明提高热解效率的关键因素。3.分析热解后产物,证明该方法是高效绿色的。结论:1.微波热解废旧轮胎的最佳条件是:轮胎样品厚度为5 mm、微波频率为915 MHz以及环境温度为592.1°C。2.分解产物中包含35%的炭黑、40%的原油以及25%的可燃性气体;这证明微波热解法是有效的。3.所有产物皆可重复利用,证明该方法是高效绿色的。