摘要：The connected and automated vehicles(CAVs)technologies provide more information to drivers in the car-following(CF)*** the human-driven vehicles(HVs),which only considers information in front,the CAVs circumstance allows them to obtain information in front and behind,enhancing vehicles perception *** paper proposes an intelligent back-looking distance driver model(IBDM)considering the desired distance of the following vehicle in homogeneous CAVs *** on intelligent driver model(IDM),the IBDM integrates behind information of vehicles as a control *** stability condition against a small perturbation is analyzed using linear stability theory in the homogeneous traffic *** validate the theoretical analysis,simulations are carried out on a single lane under the open boundary condition,and compared with the IDM not considering the following vehicle and the extended IDM considering the information of vehicle preceding and next *** scenarios are designed to evaluate the results under different disturbance strength,disturbance location,and initial platoon space *** results reveal that the IBDM has an advantage over IDM and the extended IDM in control of CAVs car-following process in maintaining string stability,and the stability improves by increasing the proportion of the new item.

摘要：结合滨水工程的特点,提出基于数字孪生技术与装配式建造理念的创新方案,构建了一套适应现代滨水场景建设需求的关键技术体系。基于GIS+BIM+IOT的滨水场景装配式一体化综合管理智慧平台,采用“二元四维”流理论与数字孪生系统,推动水利“四预”智能化功能的实现,从而提高工程建设效率、降低成本,实现智能化的运维。具体应用案例展示了该技术体系在复杂城市河道环境中的适应性与有效性,尤其是在狭窄空间和城市功能区的定制化建造中,展现出强大的灵活性和高效性。

摘要：The differential distribution between cancer cells and normal adult tissues makes survivin a very attractive cancer drug target. We have previously reported a series of novel selective survivin inhibitors with the most potent compound MX 106 reaching nanomolar activity in several cancer cell lines. Further optimization of the MX 106 scaffold leads to the discovery of more potent and more selective survivin inhibitors. Various structural modifications were synthesized and their anticancer activities were evaluated to determine the structure activity relationships for this MX 106 scaffold. In vitro anti-proliferative assays using two human melanoma cell lines showed that several new analogs have improved potency compared to MX 106. Very interestingly, these new analogs generally showed significantly higher potency against P-glycoprotein overexpressed cells compared with the corresponding parental cells, suggesting that these compounds may strongly sensitize tumors that have high expressions of the Pglycoprotein drug efflux pumps. Western blotting analysis confirmed that the new MX 106 analogs maintained their mechanism of actions by selectively suppressing survivin expression level among major inhibitors of apoptotic proteins and induced strong apoptosis in melanoma tumor cells.

摘要：Carbon supported Pt-based intermetallic compounds(IMCs)with high activity and durability are the most competitive cathode catalysts for the commercialization of proton exchange membrane fuel cells(PEMFCs).The synthesis of Pt-based intermetallics with a good balance between small size and high metal loading remains challenging because of the high-temperature annealing that is generally required to form intermetallic *** developed a sodium thiosulfate-assisted impregnation strategy to synthesize small-sized and highly ordered PtM IMCs catalysts(M=Co,Fe,Ni)with high-Pt-content(up to 44.5 wt%).During the impregnation process,thiosulfate could reduce H_(2)PtCl6 to form uniformly dispersed Pt colloid on carbon supports,which in turn prevents the aggregation of Pt at the low-temperature annealing ***,the strong interaction between Pt and S inhibits particle sintering,ensuring the formation of small-sized and uniform PtM intermetallic catalysts at the high-temperature annealing *** optimized intermetallic PtCo catalyst delivered a high mass activity of 0.72 A mgPt^(–1)and a large power performance of 1.17 W·cm^(–2)at 0.65 V under H_(2)-air conditions,along with 74%mass activity retention after the accelerated stress test.

摘要：以圆柱形孔轴配合的结合面为研究对象,研究了新一代GPS标准体系下多公差项的孔轴配合实际误差模型.以圆柱度为例,结合GPS标准中圆柱面形状误差的评定方法,采用蒙特卡洛法模拟误差的随机性,建立了孔轴圆柱面体外拟合尺寸实际变动区间求解模型,并分析实际误差对配合性质的影响.分析了包括方向公差(或位置公差)在内的三类公差耦合作用下孔轴结合面误差的形成机理,建立了不同配合性质下的圆柱形孔轴结合面的实际误差模型,获得了结合面误差分量的实际变动区间以及实际的配合性质.实现了在设计阶段对孔轴实际装配精度的预测.以实际的孔轴结合面精度与配合性质要求为约束,孔轴加工成本为目标,进行了孔轴零件的公差优化设计.最后以一孔轴配合的装配误差分析与公差优化为例,验证了该方法的可行性与实用性.

摘要：钢筋混凝土深梁受力不同于浅梁,梁腹开孔后受力更趋复杂。现有的设计方法对深梁行为的解释不够完备,设计结果的适用性难以判断,设计规范也没有给出开孔深梁的设计条文。为研究深梁设计方法的有效性,本文采用了非线性有限元分析方法,引入适合混凝土结构非线性分析的断裂塑性模型,并考虑钢筋粘结滑移效应,对一系列开双孔或偏孔钢筋混凝土深梁试验进行仿真分析,所得结果与试验结果吻合良好,能够准确预测深梁在裂缝、破坏形态及承载力等方面的受力特征。研究表明现有的深梁设计方法中,压拉杆模型方法相较内力法和应力图形法更加经济有效。在仿真分析的基础上,提出了一种对开孔深梁具有普遍适用性的非线性设计方法,其设计结果具有高承载力、较好延性、经济的配筋量和充分的材料利用率的优点。

摘要：为研究坐便器冲洗过程流态分布、流体动力学性能,优化虹吸管道而得到节水型坐便器。建立了坐便器的三维模型,应用RNGk?ε紊流模型及VOF方法对坐便器内部三维紊流流动进行了雷诺平均N-S方程的数值模拟,计算结果揭示了坐便器内流场三维流动形态,研究了坐便器虹吸管内流动规律,分析了虹吸管形状对流速分布、压强分布和虹吸性能的影响,以三维紊流场的分析结果为依据,实现了坐便器虹吸管道的优化设计。PIV测试数据验证了三维紊流数值模拟结果的准确性。

摘要：目的通过对3D打印材料与技术的概述、腰部健康护具市场需求的分析,探索3D打印技术与传统医疗护具设计结合的可能性,思考个性与适应性、艺术与功能性、单价与制造速度的平衡与协调。方法以腰部健康护具为研究切入点,借助SLS、SLA打印技术,重点关注可成型工艺(同一材料的3D打印设计改良),对增加造型可塑性以及更为概念性的设计方略层面进行研究。结果基于使用、技术、个性三方面的需求,设计了具备磁疗功效和定制特点的3D打印腰部健康护具。经实验测试,佩戴性良好,各项指标达到了设计预期。结论未来的3D打印发展方向,材料研究仍将是重点,除了材料的多元化、智慧化,技术的互动、增效也会进一步刷新人类社会的制造观念;有效利用3D打印技术的便捷性特点和可定制特点,势必成为未来“可定制化”无障碍产品设计重要的研发和探索方向。

摘要：离子光学设计是质谱仪器的核心技术,为了提高常规质谱的丰度灵敏度指标,设计了磁-电-四极杆级联质谱,并构建了一台原理实验样机。样机中的离子光学设计是仪器设计的关键内容,尤其是与最后一级质谱相关的离子透镜的设计,与常规双聚焦质谱和四极杆质谱中的透镜均有较大差异。本工作介绍了样机中的总体离子光学设计、四极杆前后相关透镜的设计、离子轨迹的SIMION仿真计算,最后通过实验调试实现了整体设计,并测试了整套设计的总体指标。结果表明,样机比原仪器的丰度灵敏度指标提高约330倍,样机最后一级的传输率约为9%,与仿真计算结果相符。

摘要：本文通过相关文献和采访海内外有影响的音乐家,结合跨学科分析法,从传播主体、传播内容和传播渠道三方面提出中国音乐跨文化传播路径:1)艺术家培育体系的构建;2)音乐中中国元素的挖掘和精细化宣传;3)打破单一的互联网运营模式,构建完善的音乐数据平台并实现音乐版权的跨界运营。本文的研究是对中国音乐跨文化传播的一次探索,也是对音乐对外传播模式构建的一种尝试,以期为中国音乐的未来发展提供新的方向和有益借鉴。