摘要：A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines（PC-3, LNCa P, and DU145） were evaluated by a CCK-8 assay. Compounds 8, 10, 13, 17 and 20 exhibited strong cytotoxic activities against the tested cancer cell lines（IC_（50）〈3 μmol/L）. In addition, these compounds exhibited weak cytotoxic effects on human epithelial prostate normal cells WPMY-1. The structure-activity relationship（SAR） of these arylpiperazine derivatives was also discussed based on the obtained experimental data.

摘要：为提高机械除草机田间精准作业能力,避免除草部件产生较大偏移伤害作物,设计了横向纠偏系统并进行相关试验分析。该系统由作物行识别与偏移量计算子系统、机械纠偏装置和控制执行子系统3部分组成。作物行识别与偏移量计算子系统由Intel RealSense D435深度相机、Jetson NX嵌入式计算设备等组成。通过改进的YOLOv5深度学习算法对作物行进行识别定位,再对得到的作物行中心点采用最小二乘法拟合直线计算出偏移量,发送给控制执行子系统。控制执行子系统接收作物行识别与偏移量计算子系统发送的偏移量,通过PID算法控制液压缸伸缩,实现机械纠偏装置的横移对行。试验结果表明:在拖拉机前进速度分别为0.63、1.56、2.25 km/h时,横向纠偏系统的平均对行准确率分别为91.8%、88.7%、87.4%,对行纠偏平均响应时间分别为1.4、0.8、0.5 s。该系统可以有效缓解农机具在大田除草作业过程中对行不准造成作物植株损伤的问题。

摘要：当前在我国,创意产业正处于高速发展期,这为艺术设计教育提供了广阔的发展空间,同时也为艺术设计专业的改革和发展指明方向。高校艺术设计专业的教学如何适应当下创意产业市场的人才需求,提高人才培养质量是艺术设计教育必须重新探讨和研究的课题。本文以创意产业为背景,以艺术设计人才培养目标和社会需求的一致性为基本出发点,探讨艺术设计教育的现状及特点,分别从培养目标、课程设置、教学模式三个方面对艺术设计实践教学进行探究和阐述,从而切实提高设计人才的培养质量。

摘要：The WorM＇s Wife （1999）, written by Carol Ann Duffy, who is the first woman and first openly LGBT person appointed Britain＇s poet Laureate, is a collection of poems which makes full use of intertextuality to show Duffy＇s subversion to patriarchy. In this collection, histories and myths are parodied, quoted, alluded and even rewritten. Women in her poems are given chances to speak out for themselves, which can be seen as a form of resistance against patriarchy. In this article, constitutive intertextuality as well as manifest intertextuality like parody, quotation and allusion in The WorM＇s Wife will be discussed specifically. By analyzing how those intertextual features are adopted as a form of resistance against patriarchy, this article aims to help readers form a better perception of the feminism Duffy raises, and tries to help more women who are being suppressed by men, to find and reconstruct their identities.

摘要：We develop here a simple wet chemistry to prepare covalent functionalized graphenes （FGs） through epoxide aminolysis espe- cially under alkaline aqueous condition. Remarkably, a series of typical monoamines, such as industrial Huntsman Jeffamine M-2070 and M-2005 polymer with hydrophilic or hydrophobic polyetheramine chains, positively-charged 2-amino-N,N,N- trimethylpropanaminium, negatively-charged sulfanilic acid, even oligopeptide sequence, can be effectively grafted on the platelets of graphene oxide precursor with covalent functionalization and partially reduced features. This strategy provides the researchers a facile and convenient approach to design and synthesize solution processable, biocompatible and functionalized graphenes for the potent applications in electronic inks, drug carriers and biomedicines. Expansion of the current study is actively ongoing in our laboratory.

摘要：随着室内混合定位技术的发展,室内路径规划和导航已成为研究热点。常规手机地图主要关注单楼层路径规划,致使用户在多楼层建筑中导航时效率低下。因此,开发高效的手机室内导航系统至关重要。该文利用React框架和Leaflet地图库搭建了系统界面,基于Dijkstra算法设计了跨楼层路径规划模型,使用JavaServlet构建了路径服务小程序,采用MySQL管理GIS数据和关系型数据。系统的功能需求全面考虑了用户群体、基本操作、地图导航、主题设计、错误处理和反馈机制等因素。测试结果表明,该系统能高效准确地实现室内地图导航服务,显著提升了室内导航体验。系统提供的跨楼层路径规划能力为多楼层建筑中的导航需求提供了有效解决方案。该研究为室内导航技术的发展提供了新思路,并为大型商场、机场、医院等多层建筑中的应用奠定了基础。未来应关注系统的扩展性、智能化水平及对不同建筑类型的适应性,以推动室内导航技术的持续进步。

摘要：随着社会经济的发展以及科学技术的进步,创新创业教育得到了良好的发展空间,有力推动了教育事业的长远发展。高职电脑艺术设计专业作为一门综合性学科,其具有一定的交叉性和专业性,是专业素质与专业技能、实践与理论、技术与艺术的有机结合,能够有效满足人才市场的需求。目前大部分高职院校都开始改变传统的教学模式,创设人才市场与企业、行业与教育的合作及对接机制,创新人才培养理念,以此形成适合创意产业环境下的人才培养体系,实现自身的可持续发展。本文对创意产业环境下高职电脑艺术设计专业人才培养路径进行深入分析和探讨。

摘要：The advent of the 5G era has stimulated the rapid development of high power electronics with dense ***-dimensional(3D)thermally conductive networks,possessing high thermal and electrical conductivities and many different structures,are regarded as key materials to improve the performance of electronic *** provide a critical overview of carbonbased 3D thermally conductive networks,emphasizing their preparation-structure-property relationships and their applications in different scenarios.A detailed discussion of the microscopic principles of thermal conductivity is provided,which is crucial for increasing *** is followed by an in-depth account of the construction of 3D networks using different carbon materials,such as graphene,carbon foam,and carbon *** for the assembly of two-dimensional graphene into 3D networks and their effects on thermal conductivity are ***,the existing challenges and future prospects for 3D carbon-based thermally conductive networks are discussed.

摘要：Electrochemical CO_(2)reduction to value-added fuels and chemicals is recognized as a promising strategy to alleviate energy shortages and global warming owing to its high efficiency and economic ***,understanding the activity origin,selectivity regulation,and reaction mechanisms of CO_(2)reduction reactions(CO_(2)RRs)has become the focus of efficient electrocatalyst ***(POMs),a unique class of nanosized metal-oxo clusters,are promising candidates for the development of efficient CO_(2)RR electrocatalysts and,owing to their well-defined structure,remarkable electron/proton storage and transfer ability,and capacities for adsorption and activation of CO_(2),are ideal models for investigating the activity origin and reaction mechanisms of CO_(2)RR *** this review,we focus on the activity origin and mechanism of CO_(2)RRs and survey recent advances that were achieved by employing POMs in electrocatalytic CO_(2)*** highlight the significant roles of POMs in the electrocatalytic CO_(2)RR process and the main factors influencing selectivity regulation and catalytic CO_(2)RR performance,including the electrolyte,electron-transfer process,and surface ***,we offer a perspective of the advantages and future challenges of POM-based materials in electrocatalytic CO_(2)reduction that could inform new advancements in this promising research field.

摘要：在航空发动机发生转静子碰摩时,发动机振动信号会出现频率调制(FM)的现象。频率调制会导致瞬时频率波动,它携带着航空发动机的关键故障信息。本文采用频率选择性滤波器分别对振动信号进行处理,将振动信号分别滤波为两个信号分量,将奇异值分解用于降低每个信号分量的噪声。希尔伯特(Hilbert)变换用于从振动信号中提取振荡瞬时频率。该方法通过数值模拟进行了验证,然后通过具有碰摩故障的航空发动机数据进行了验证,经验证该方法适用于检测航空发动机碰摩故障。