摘要：A series of novel 5-sulfoxide-substituted pyrazolo[5,1-d] [1,2,3,5]tetrazin-4（3H）ones 4a-j were designed and efficiently synthesized via a diazotization of 5-amine-3-methylsulfinyl- 1H-pyrazole, followed by cycloaddition with aryl isocyanate. A possible reaction mechanism is outlined and discussed. These new compounds exhibit some biological activity as preliminary bioassay indicated. Their structures were confirmed with ^1H NMR, IR and elemental analysis.

摘要：将新鲜鸡蛋分别在沸水中煮制10、15、20、25 min,通过测定蛋清水分含量、蛋黄水分含量、水分T_2驰豫分布、质构以及蛋黄脂质组成,探究不同煮制时间对鸡蛋质构及脂质营养成分的影响。结果表明,蛋清蛋白在煮制15 min后完全凝胶,而蛋黄则在20 min后完全凝胶。蛋黄中具有生物活性功能的磷脂酰胆碱(PC)、磷脂酰乙醇胺(PE)、磷脂酰己醇(PI)、磷脂酸(PA)、磷脂酰甘油(PG)和神经酰胺(Cer)均在煮制15 min的样品中含量最高,只有鞘磷脂(SM)的含量在煮制时间10 min的样品中含量最高,其次是煮制15 min的样品。单不饱和脂肪酸(∑MUFA)含量煮制前15 min下降显著(p0.05);而多不饱和脂肪酸(∑PUFA)则在煮制前15 min含量变化不显著,之后随煮制时间延长含量显著下降(p<0.05)。由此可得,煮制时间为15 min时,鸡蛋的质构及蛋黄脂质营养最好,这将为工业化生产早餐水煮鸡蛋或者卤蛋生产提供一定的理论指导。