摘要：彩色点画是一种从视觉上由大量小像素点构建图像的艺术技术,像素个数的多少直接影响着构图的成本。其优化选点构图方法为实现低成本打印提供了一个重要的方式。目前,点画生成存在着多通道采样点难以均匀分布,颜色层次难以兼顾等难点,并耗费大量的计算成本。对此,提出了一种基于超像素自适应聚类和线性规划最优选点的彩色点画生成方法,该方法在初步超像素划分图像的基础上,使用基于颜色密度峰值的自适应聚类方法得到最佳聚类个数,并进一步划分子聚类,然后根据每个子聚类的颜色均值作为子聚类内部选点的最佳间隔距离,在选点的同时依据SSIM指标,建立目标优化模型,通过数学优化器Gurobi实现模型选点,使点保留最少个数的目标基础上,同时保持聚类内部分布均匀和颜色渐变层次,以提高所生成的点画图像的可视化效果。实验结果表明,本文算法极大地降低了像素个数并在生成的点画的平均结构相似性(mean structural similarity index measure,SSIM)、峰值信噪比(peak signal to noise ratio,PSNR)等评价指标方面均优于当前方法。

摘要：A series of small-molecular fluorescent probes based on nitrogen-fused pyridazinone scaffold were developed in this *** design strategy involved two steps:1)enhancing the electron-withdrawing ability of the acceptor by incorporating an N-heterocyclic aromatic ring(pyridine or pyrazine)at the C4 and C5 positions of the pyridazinone skeleton and 2)anchoring a triphenylphosphine or morpholine tail as the subcellular targeting *** fluorescent probes displayed excellent properties in live cell and brain tissue imaging.

摘要：Fragment-based drug discovery （FBDD） has been widely applied in the research of aspartyl protease inhibitors. In the present study, we reported our work on 2-aminobenzimidazole as the original fragment, which was predicted to bind with the catalytic aspartyl dyad （Asp228 and Asp32） of D-site amyloid precursor protein cleaving enzyme 1 （BACE1）. A series of novel 2-aminobenzimidazole derivatives were designed and synthesized. The results from FRET assay revealed that three out of the 12 designed 2-aminobenzimidazoles could inhibit more than 50% of the enzymatic potency of BACE1 at 10 pM. Docking study showed that 2-aminobenzimidazole could form multiple hydrogen bonds and occupy S1/$2＇ pockets well.

摘要：柔性化是当前汽车主机厂所普遍采取的生产策略,条形码技术作为车身识别的手段在该策略中起着举足轻重的作用。然而由于条形码质量问题导致的识别系统可靠性较低的问题给生产活动带来了困扰和挑战。为了提高车身识别成功率从而提高汽车装配线的生产效率,研究了提高数字化控制系统可靠性的问题,创新性地提出了基于RFID识别系统冗余设计的解决方案。对导致控制系统可靠性降低的条形码识别失效进行了分析,对RFID系统设计进行了阐述,最终给出优化后的冗余系统程序流程。该系统的应用有效地提高了控制系统可靠性及汽车装配线的生产效率,取得了良好的经济效果,具备一定的示范效应。

摘要：Previous studies have shown that Ras/Raf/MEK/ERK signaling pathway is up-regulated in almost all cancer *** of this pathway by MEK inhibition is an efficient therapeutic approach of *** the present study,we described the discovery of 5-benzyl-2-phenylpyrimidin-4（3 H）-one as a novel skeleton of allosteric MEK *** acquired target compounds exhibited modest potency to inhibit MEK1 in Raf-MEK cascading assay,and docking studies revealed that the binding mode of the most potent compound（SJ3） was very similar to that of the well known diarylamine-based inhibitor（PD0325901）.The results provided valuable guidance for further optimizations on this novel scaffold to achieve druggable molecules.

摘要：Based on the structure of compound B51（IC_（50） = 37.4 μM）, which was discovered as hit in a previous virtual screen, a series of methylisoxazole/isothiazole amide derivatives were designed and synthesized as BACE1 inhibitors. The methoxyphenylpyrimidone fragment of B51 was transformed into a methoxyphenylmethylisoxazole/isothiazole moiety to reduce the molecular weight while retaining the ability to fit into the S1＇ and S2＇ subpocket of BACE1 as predicted by docking studies. The effects of BACE1 inhibition and the structure-activity relationships were analyzed. Among all 20 designed compounds, 5t exhibited almost 10-fold improved potency（IC_（50） = 5.33 μM） compared to B51 in the BACE1 inhibition assay. Additionally, it has exhibited ＂rapid binding, slow dissociation＂ kinetics in SPR analysis, suggesting a longer inhibitory effect than B51. All acquired methylisoxazole/isothiazole derivatives were small in size and safe to normal cells, which allow them represent a novel scaffold for BACE1 inhibitor design.

摘要：研究旨在采用Meta分析方法分析芝麻粕替代豆粕饲粮对肉羊生长性能及肉品质的影响,为芝麻粕作为肉羊饲料蛋白源的可行性提供依据。通过关键词相互组合的方式在中英文数据库中搜集相关文献。按照纳入排除标准共纳入8篇文献,包括试验组138只用芝麻粕替代豆粕饲喂的羔羊,对照组66只用豆粕饲喂的羔羊,以平均日增重和料肉比作为生长性能参数;以屠宰后pH24 h、剪切力、系水力作为羊肉品质主要参数,共收集204只羔羊的相关数据。通过RevMan软件进行Meta分析,根据森林图检查纳入文献是否具有异质性,通过亚组分析确定异质性来源,最后进行灵敏度分析,评价分析结果的稳定性,根据漏斗图评估文献发表偏倚。结果表明:芝麻粕替代豆粕饲粮显著提高了肉羊的平均日增重(P≤0.05),显著降低了料肉比(P≤0.05)。对于羊肉宰后pH24 h、剪切力、系水力均无显著影响(P>0.05)。亚组分析发现,芝麻粕替代比例低于20%时能极显著提高肉羊的平均日增重(P<0.01)和显著降低料肉比(P≤0.05);饲喂周期大于70 d时,能够显著提升肉羊的平均日增重(P≤0.05),显著降低料肉比(P≤0.05)。灵敏度分析显示,Meta分析结果稳定、可靠,漏斗图显示纳入文献无发表偏倚。综上所述,芝麻粕替代豆粕能够显著提升肉羊的生长性能,当饲粮中芝麻粕替代豆粕比例低于20%和饲喂周期大于70 d时对肉羊生长性能的提升最为显著,而且对肉品质无任何负面影响,从生产性能的角度来说,芝麻粕可以作为肉羊的一种新型饲料蛋白源。

摘要：针对目前环境声音分类(Environmental Sound Classification, ESC)方法对音频特征提取中反映的时频维度信息不足的问题,提出基于多组多分辨率特征和小波通道注意力的分类方法。采用多组多分辨率特征组成的多特征作为网络输入,通过多组滤波器,多个频率分辨率,在时间和频率维度上实现数据增强,同时实现信息互补。为了更好地衡量各个通道的重要性,针对一维音频图像特征设计了小波通道注意力模块,采用离散小波变换(Discrete Wavelet Transform, DWT)将信号的低频子带和高频子带有效结合,得到通道标量,利用Gram-Schmidt正交化方法使网络在信道注意压缩阶段提取的信息多样化,利用长短期记忆(Long Short Term Memory, LSTM)网络长时间保存信息,提高学习的长期可靠性。实验结果表明,在ESC-10和ESC-50数据集上的分类准确度分别达到了98.7%和93.6%,取得了较好的效果,为音频特征处理提供了一种新的研究思路。

摘要：在20世纪,西方的学者产生了对东方文化的向往,与此同时中国大批的学者留学西方,接受欧美文化的冲击,在艺术上产生了新的文化碰撞。西方人认识到东方文化的魅力和神奇,我们也吸收西方文化,有利于我们理解文化开阔视野。就我们的艺术而言,或设计学来讲,进行东西方设计理念的比较,有利于我们创新的设计作品,创造出新的设计观念,形成新的设计艺术思想。实现东西方美学思想的比较与交融,是整体把握世界文化性艺术美学的关键。

摘要：随着我国国民经济的不断发展,饲料产业作为第一产业中的核心组成部分,其发展情况对区域经济发展起着不可或缺的作用。在实际运营过程中,饲料企业的关键技术、原料采购、期货价格波动等要点涉及的专业门类较多。为保障饲料企业的高效运营,其内部控制制度的设计尤为重要。因此,饲料企业内控制度设计合理与否就成为这一问题的关键。本文以饲料企业为研究对象,以内控制度为主要切入点,针对内部控制制度设计中可能存在的问题展开讨论,最后提出解决措施,以期为饲料企业可持续发展提供参考。