摘要：The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimating an average knee valgus angle value for northern Chinese adults. Computed tomographic angiography data in DICOM format for 128 normal femurs from 64 adult subjects were chosen for analysis. After the femur images were subjected to three-dimensional reconstruction, the deepest point in the intercondylar notch （point A）, the midpoint of the medullary cavity 20 cm above the knee-joint line （point B）, and the landmark of the femoral head rotation center （point C） were identified on each three-dimensional model. The knee valgus angle was defined as the angle enclosed by the distal femoral anatomical axis （line AB） and the femoral mechanical axis （line AC）. The average （mean＋SD） of knee valgus angle for the 128 femurs was 6.20°±1.20° （range, 3.05° to 10.64°）. Significant positive correlations were found between the knee valgus angles of the right and left sides and between the knee valgus angle and age. During total knee arthroplasty, choosing a valgus cut angle of approximately 6° may achieve a good result in reestablishing the natural mechanical alignment of the lower extremity for patients of northern Chinese ethnicity. Larger valgus cut angles should be chosen for older patients.

摘要：通过对某高速公路大桥病害原因调查及分析,根据具体病害和结构特点,提出了该大桥T梁、横隔版及盖梁的加固设计方案,并借助于桥梁博士建立全桥结构分析模型,对加固前后内力进行了对比。结果表明,针对不同病害特点选取合理的加固方案,能有效增强桥梁的承载能力或降低截面弯矩,使部分病害严重的桥梁经加固后仍处于安全工作状态,既节约了资金又保证了安全,也为类似工程设计提供了参考。

摘要：根据拉舍尔多梳栉花边工艺设计原理及步骤 ,分析了地组织、意匠图、花边垫纱之间的关系 ,设计了多梳栉花边CAD软件。应用该软件 。

摘要：随着公路、铁路交通的不断发展,钢筋混凝土或预应力混凝土桥梁占据了全国桥梁的绝大多数。经多年使用后,部分桥梁病害严重,不得不重建或加固。文章结合目前桥梁加固现状,提出了灌浆、植筋、施加体外预应力的旧桥加固施工技术,并详细介绍了施工要点,为桥梁加固提供了一些经验,对桥梁加固具有一定的参考价值。

摘要：近年来,越来越多的人注重身材的管理,束身衣作为一种功能性服装在国内销量持续增长,该产品对功能性与舒适性有较高的要求,需要有针对性的数据作为依据,所以对其消费群体体型特点的研究是非常有必要的。

摘要：目的克隆并构建5种截短型神经连接蛋白-1(tneuroligin-1,tNL-1)可溶性细胞外片段的原核表达载体,经表达、纯化后获得重组GST-tNL-1融合蛋白,初步探讨其对阿尔茨海默症(Alzheimer disease,AD)的治疗效果。方法对神经连接蛋白-1(neuroligin-1,NL-1)的结构特征及理化性质进行生物信息学分析。利用NL-1细胞外片段设计5个截短片段(tNL⁃1①~⑤),以NL-1细胞外片段1-691质粒为模板PCR扩增目的片段,构建pGEX-6P1-tNL⁃1原核表达载体,筛选最佳诱导条件后,表达重组tNL-1蛋白,经GST亲和层析法纯化重组蛋白。制备β淀粉样蛋白(β-amyloid protein,Aβ)寡聚体,并进行Western blot鉴定。将体外培养的人SHSY-5Y细胞随机分为3组:对照组(不加任何干预)、模型组(40μg/mL Aβ处理24 h)、实验组(Aβ与20、40、60μg/mL tNL-1②共处理24 h),MTT法检测tNL-1②对Aβ诱导的SHSY-5Y细胞的保护作用。结果NL-1有12个蛋白修饰位点,预测其中有8个修饰位点两两相关联,据此关联设计了5个截短体。质粒pGEX-6P1-tNL⁃1经双酶切及测序鉴定证明构建正确。最佳诱导条件为:37℃培养2 h,A600为0.8时降温至16℃,加入0.1 mmol/L IPTG诱导12 h。表达及纯化的重组tNL-1①~⑤蛋白相对分子质量分别约为68000、90000、66000、53000和62000,大小均与预期相符,且可被抗体特异性识别。制备的Aβ寡聚体在相对分子质量约4000和12000处条带明显,主要以单体和三倍体形式存在。MTT结果显示,与对照组相比,模型组细胞生存率明显下降(P=0.001);与模型组相比,实验组细胞生存率均明显升高(P<0.001)。结论Aβ对SHSY-5Y细胞存在毒性作用,制备的tNL-1能缓解Aβ对SHSY-5Y细胞模型的的增殖抑制作用。后续会将tNL-1蛋白应用于更多体内外试验中,为AD的治疗提供新思路。

摘要：设计4种日粮配方,经92d育肥,结果表明:试验1～4组平均日增重分别为244、224、167和189g,屠宰率、净肉率和眼肌面积和GR值等指标都以第一组最优,但经济效益排列顺序为第2、第1、第4和第3组。

摘要：Changes in requirements may result in the increasing of product development project cost and lead time, therefore, it is important to understand how require- ment changes propagate in the design of complex product systems and be able to select best options to guide design. Currently, a most approach for design change is lack of take the multi-disciplinary coupling relationships and the number of parameters into account integrally. A new design change model is presented to systematically analyze and search change propagation paths. Firstly, a PDS-Be- havior-Structure-based design change model is established to describe requirement changes causing the design change propagation in behavior and structure domains. Secondly, a multi-disciplinary oriented behavior matrix is utilized to support change propagation analysis of complex product systems, and the interaction relationships of the matrix elements are used to obtain an initial set of change paths. Finally, a rough set-based propagation space reducing tool is developed to assist in narrowing change propagation paths by computing the importance of the design change parameters. The proposed new design change model and its associated tools have been demonstrated by the scheduling change propagation paths of high speed train＇s bogie to show its feasibility and effectiveness. This model is not only supportive to response quickly to diversified market requirements, but also helpful to satisfy customer require- ments and reduce product development lead time. The proposed new design change model can be applied in a wide range of engineering systems design with improved efficiency.

摘要：目的:评估电影疗法在团体心理辅导中增强大学生生命意义感知的影响成效。方法:以电影《那山那人那狗》为教学素材,运用生命意义感理论、电影疗法、萨提亚模式和团体动力学等知识,涵盖观察学习、隐喻以及投射与认同等心理基础,探寻生命意义感团体心理辅导的作用机制。将自愿接受团体辅导的72名大二学生作为研究对象,其中36人作为对照组,36人作为干预组,运用扎根理论分析干预组生命意义感的三次访谈,以构成维度及发展机制。结果:大学生生命意义感的心理发展过程分为混沌期、觉察期和觉悟期等三个阶段,确定了生活质量、社会关系、价值观以及自我发展等四个维度,从而为生命意义感提供了兼具广度与纵深性的框评估架。结论:电影疗法在提升大学生生命意义的认知水平以及激发其探寻生命意义的动力方面发挥着积极作用,彰显出时代价值,为高校心理健康教育模式的创新提供了崭新的视角与范例,具有重要的应用推广价值。

摘要：目的:本文旨在对系列文章第一部分所得到的理论推导结果进行相应的有限元数值验证,同时对内核单波变形下的支撑构件进行参数分析。方法:采用通用有限元软件ABAQUS建立六个防屈曲支撑模型对内核单波变形下理论推导公式进行校核;并对理论公式进行参数分析,考察外围构件抗弯刚度、间隙大小、内核构件厚度、内核构件宽厚比、铰接接头长度、外围约束构件初始缺陷、外围构件长度、内核约束加强段长度及内核加强段翼板高度等9个参数对内核挤压力及外围构件受力影响;最后通过对12个防屈曲支撑进行数值模拟,验证支撑设计理论的合理性。结论:该理论设计公式能较好地预测支撑的破坏情况及内力发展情况,具有较强的安全性和较广的适用性,为铰接防屈曲支撑的使用推广奠定理论基础。