摘要：The growth plate(GP)is a crucial tissue involved in skeleton development via endochondral ossification(EO).The bone organoid is a potential research model capable of simulating the physiological function,spatial structure,and intercellular communication of native ***,mimicking the EO process remains a key challenge for bone organoid *** simulate this orderly mineralization process,we designed an in vitro sh Ca_(v)3.3 ATDC5-loaded gelatin methacryloyl(Gel MA)hydrogel model and evaluated its bioprintability for future organoid *** this paper,we report the first demonstration that the T-type voltage-dependent calcium channel(T-VDCC)subtype Ca_(v)3.3 is dominantly expressed in chondrocytes and is negatively correlated with the hypertrophic differentiation of chondrocytes during the EO ***,Ca_(v)3.3 knockdown chondrocytes loaded with the Gel MA hydrogel successfully captured the EO process and provide a bioink capable of constructing layered and orderly mineralized GP organoids in the *** results of this study could therefore provide a potential target for regulating the EO process and a novel strategy for simulating it in bone organoids.

摘要：Art Deco风格在现有的建筑中既有机的融合了现代主义的简约,又继承了古典主义的精致。在现有的建筑中适当的运用Art Deco风格,满足建筑使用功能的同时又兼具了建筑美观。

摘要：AIM:To introduce a new near-vision chart for children aged 3-5 years old and its clinical ***:Thenewnear-visionchartwhichcombined the Bailey-Lovie layout with a newly devised set of symmetry symbols was designed based on WeberFechner *** consists of 15 rows of symmetry symbols,corresponding to a visual acuity range from 1.3 to *** optotypes were red against a white background and were specially shaped four basic geometric symbols:circle,square,triangle,and cross,which matched the preschool children’s cognitive level.A regular geometric progression of the optotype sizes and distribution was employed to arrange in 15 *** progression rate of the optotype size between two lines was 1.2589 and two smaller groups of optotypes ranging from 0.7 to-0.1 logMAR were included for repetitive testing.A near visual acuity was recorded in logMAR or decimal,and the testing distance was 25 ***:This new near-vision chart with pediatric acuity test optotypes which consists of 4 different symbols(triangle,square,cross,and circle)met the national and international eye chart design *** performing the near visual acuity assessment in preschoolers(3-5y old).It overcame an inability to recognize the letters of the alphabet and difficulties in designating the direction of black abstract symbols such as the tumbling’E’or Landolt’C’,which the subjects were prone to lose interest *** vision may be recorded in different notations:decimal acuity and *** two notations can be easily convertedeach other in the new near-vision *** measurements of this new chart not only showed a significant correlation and a good consistency with the Chinese national standard logarithmic near-vision chart(r=0.932,P<0.01),but also indicated good test-retest reliability(89%of retest scores were within 0.1 logMAR units of the initial test score)and a high response ***:The results of this study support the validity and reliability of

摘要：文章以正向开发的思路,梳理高压性能指标设计依据、主要内容以及测试验证要求,为电动汽车高压系统集成提供设计参考。

摘要：为使前纵梁具有良好的静态和动态特性,提高汽车耐撞性,本文以正八边形梁作为汽车前纵梁的拓扑优化设计空间,充分考虑静态拓扑优化和动态拓扑优化方法的各自优势,将变密度法和混合元胞自动机法结合起来,对前纵梁进行耐撞性优化设计。通过静态拓扑优化方法获得前纵梁在轴向刚度最大和侧向刚度最大时的结构形式;通过动态拓扑优化方法获得前纵梁在满足轴向强度下的最大吸能结构形式。由拓扑优化结果,最终确定前纵梁的最优拓扑构型,并通过台车试验进行验证。研究结果表明:将拓扑优化后的前纵梁应用于Explorer整车正面碰撞中,B柱加速度峰值减少了5.50g,整车安全性能得到有效提高。

摘要：Elevated working temperatures reduce the efficiency of dye-sensitized solar cells （DSCs）, and effective temperature regulation protects them from the undesirable efficiency loss. In this work, a semi-transparent DSC module equipped with a cooling sys- tem was designed and constructed for application in buildings, the temperature and output performance of the modules with or without cooling treatment were investigated. The test results showed the cooling system could noticeably improve the power generation and reduce the module temperature. Moreover, we established a mathematical model to analyze the modules＇ ther- mal performances, and introduced the concept of cooling efficiency to evaluate the cooling effect. The model accuracy have been validated utilizing measured data, and the effects of channel depth and mass flow rate on the module temperature and cooling efficiency were further theoretically studied. The combined DSC module has been found to have a good application prospect in building integrated photovoltaic （BIPV）, and the numerical results are important in system design.

摘要：在环境艺术设计中,需要对环境信息缺失部分进行有效修复,提高环境艺术的信息表达能力。提出一种基于块与块阵稀疏度匹配的图像修复技术,并应用在环境艺术设计中。在仿射不变子空间中对采集的环境艺术图像进行块匹配,采用模板匹配技术进行图像破损区域的边缘像素点提取,以边缘像素点为信息定位中心,提取环境艺术图像破损区域的边缘轮廓,根据边缘轮廓的像素点分布阵列的稀疏度差异性进行块匹配,在最佳修复块区域内进行环境艺术图像的纹理信息复原,提高环境艺术的鉴别和分辨能力。仿真结果表明,采用该方法进行图像修复能有效修复环境艺术图像的缺失部分,避免边缘模糊化,输出图像的信息饱含度较高,说明环境艺术的表达能力较强,在环境艺术设计中具有很好的应用价值。

摘要：创意经济是一种以人为本的经济发展观,这主要体现在它的兴起、发展和前景三方面:创意经济的兴起,标志着未来经济发展愈加彰显人的因素;创意经济的发展,预示着人才将成为推动经济发展的关键动力;创意经济的前景,说明只有人是经济发展的深层动力。

摘要：目前各高校正积极探索“互联网+教育”教学方式,打破传统教学模式的弊端,开展Seminar教学模式改革,提高教学质量。本文以“智慧树”为平台,结合Seminar教学模式,从课前课程设计,课中讨论交流,课后监督改进3个方面开展皮肤性病学的教学活动,优化教学方式,提高教学质量,同时提高学生的积极性与探究性。

摘要：纳米金属氧化物(MO_(x))易通过呼吸进入肺部,诱发肺细胞毒性,进而导致肺部多种疾病。仅通过实验方法评估毒性面临效率低、成本高和伦理问题等局限性。对MO_(x)的肺部细胞毒性进行全面评估,有利于防治新污染物的健康危害。为了充分利用现有毒性数据,本研究开发了肺细胞(A549细胞)毒性高通量预测模型,对传统毒性实验进行了补充。通过文献挖掘,构建了MO_(x)诱导肺细胞毒性数据集,涵盖9种MO_(x)在8种不同浓度下产生的72个毒性数据点,以及材料密度、粒径等29种性质参数。使用合成少数类过采样技术(SMOTE)算法处理不平衡数据,构建了基于多种机器学习算法的预测模型,表现最优的模型在训练集十折交叉验证和测试集外部验证中准确率分别超过0.90和0.85。基于Shapley可加性特征解释方法(SHAP),识别了暴露浓度、暴露时间以及材料分散指数等影响毒性的5个关键参数,阐明了毒性机理。基于相似性网络图对建模数据的代表性及模型应用域进行了表征。本研究构建的机器学习模型实现了MO_(x)毒性的高通量准确预测,可以作为纳米材料毒性评估和安全设计的有力工具。