摘要：In an attempt to develop potent antitumor agents,new rhodacyanine analogues containing the pyridinium ring（5a-5h）,the isoquinolinium ring（6a-6c） and the quinolinium ring（7a-7e） linked to the rhodanine ring via N-N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line（H460） by MTT assay in *** of the tested compounds showed enhanced antitumor activity with IC_（50） values ranging from 0.006 to 9.2 u,mol/L as compared to the lead compound *** them,the most promising compound 7d（IC_（50） = 0.006μmol/L） was 216.7 times more active than MKT-077（IC_（50） = 1.3μmol/L）.The preliminary structure-activity relationship of the target compounds was discussed.

摘要：老龄服务产业是一门新兴的产业,在我国起源于20世纪80年代。到了20世纪90年代后,我国整体进入老龄化国家行列,老龄服务产业逐步受到重视,尤其是进入21世纪后,随着我国老龄化的加速,国家制定了一系列鼓励老龄服务产业发展的政策,财政支持力度也在逐步加大,老龄服务产业得到初步发展,尤其是老龄化程度较为严重的城市,老龄服务产业发展迅猛。但是老龄服务产业在发展过程中也存在一些不足,包括顶层设计的偏差、政府与市场的边界模糊、供需的结构性矛盾等。为此需要进一步加强顶层设计、厘清政府与市场的边界、加强供给侧改革等。

摘要：新型农村合作医疗基金在征缴中应针对不同经济类型地区设计合理的筹资结构,实行半强制原则,建立缴费合理增长机制;在基金的补偿过程中应坚持“保大”原则,补助结构适当向基层医院倾斜,并适当降低起付线,提高封顶线。另外还应建立医疗救助制度,改革医疗卫生体制。

摘要：JDJS-2是江南大学机械工程系研制的机械设计软件包,该软件包可以完成一般机械工厂常用的通用的机械零、部件的设计计算及绘图。全部设计采用人——机对话方式进行,操作十分方便,设计计算准确、迅速。特别适宜于在中、小企业中推广使用。

摘要：为研究多层自复位框架结构整体抗震性能,进行一个1/4缩尺比六层自复位框架结构模型的模拟地震振动台试验,研究该结构的动力特性及其在7度多遇至7度极罕遇4个水准地震作用下的动力反应和破坏情况。试验结果表明:在多遇以及设计基本地震作用下,结构构件无可见裂缝和损伤;随着输入地震动峰值的增加,结构损伤增加,但损伤主要集中在梁、柱端的表面混凝土,构件自身几乎没有损伤,表明自复位混凝土框架结构的抗震性能良好;在7度罕遇地震作用下,主体结构最大层间位移角为1/62,自复位框架的节点开始张开;在7度极罕遇地震作用下,模型节点张开更加明显,角钢进入屈服阶段,而主体结构的最大残余位移角仅为1/2533,证明结构具有很强的自复位能力。

摘要：20世纪80年代,美国兴起了一场关于护理院的“文化变革运动”,在其影响下,护理院经历了从“机构化”向“家庭化”发展的演变。“文化变革运动”的“家庭化”理念表现在伦理价值观、机构管理、护理服务、环境设计四个方面,其形成的动因在于:代际间服务需求的变化、政府监管以及护理院的利益驱动。“家庭化”的理念与美国文化相契合,和福利机构“去机构化”发展相互补充,对美国护理院行业发展产生了深远影响,但也在新冠肺炎疫情中暴露出其缺陷。“文化变革运动”中的经验做法对中国失能老年人、残疾人的长期护理实践有着借鉴价值。

摘要：Acute respiratory distress syndrome(ARDS)is characterized by the severe inflammation and destruction of the lung aireblood barrier,leading to irreversible and substantial respiratory function *** with coronavirus disease 2019(COVID-19)have been encountered with a high risk of ARDS,underscoring the urgency for exploiting effective ***,proper medications for ARDS are still lacking due to poor pharmacokinetics,non-specific side effects,inability to surmount pulmonary barrier,and inadequate management of *** increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting *** has demonstrated unique advantages in solving the dilemma of ARDS drug therapy,which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug *** passive,active,or physicochemical targeting,nanocarriers can interact with lung epithelium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment,thereby showing good therapeutic activity and reduced *** article reviews the latest applications of nanomedicine in pre-clinical ARDS therapy,highlights the strategies for targeted treatment of lung inflammation,presents the innovative drug delivery systems,and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment.

摘要：文中围绕人才培养方案和培养目标,结合学院的课程教学改革项目,基于工作过程重构具有工学结合特色的物流信息管理专业课程体系。以物流管理的流程为经线,以物流信息技术的应用为纬线,融入国家职业资格标准,开发和设计了基于工作过程工学整合的《物流信息技术应用》课程。

摘要：In order to find a new variety of ryanodine receptor(RyR)regulator with greater biological activity,a se-ries of anthranilic diamide derivatives possessing pyrrole structure was designed and synthesized in this *** pyrrole derivatives were evaluated for their insecticidal activity against Mythimna separata and Plutella *** indicated by the preliminary biological activities,compounds 12h-12j and 121-12n exhibited a remarkable in-secticidal activity against *** at 0.25 mg/*** to control *** 12i exhibited more excellent insecticidal activity at 0.1 mg/***,compounds 12c,12h,12i.12j.121,and 12m were selected to test the insecticidal activity against P xylostella,which led to the desirable insecticidal activity at 1x103 mg/***,compound 121 demonstrated 47%insecticidal activity at 5×10^(-6) mg/L over the *** addition,the biological mechanism of action of compound 12i was investigated by means of insect clectrophysiology experiment.

摘要：文中主要讨论了二维条码PDF417条码的特点和编码原理,利用Visual Basic编程语言,通过优化的算法,完成了其生成编码打印软件的设计和实现。经验证,该程序可以准确无误地实现PDF417二维条码的编码和打印,还十分有利于分析编码数据,为供应链管理系统奠定了良好基础。