摘要：o.jective: To.investigate the effects o. ho.mo.e therapy, estro.en therapy and tibo.o.e o. markers o. apo.to.is including bcl-2, and bax and cyclin D 1 expressio. in po.tmeno.ausal vaginal epithelium. Study design: Thirty po.tmeno.ausal wo.en were rando.ized to.the treatment pro.o.o.s (0.625 mg co.jugated equine estro.en (CEE) ? 2.5 mg medro.ypro.estero.e acetate (MPA); 2 mg estradio. valerate; 2.5 mg tibo.o.e). After baseline vaginal bio.sy, co.tro. bio.sies were perfo.med after 70 days fo.lo.ing the initiatio. o. the therapy. Bcl-2, bax, Bcl-2/bax ratio. cyclin D1 measurements were perfo.med immuno.isto.hemically. Data were analyzed by Kruskal-Wallis, Mann-Whitney U and Wilco.o. tests. Results: After the treatment perio. the abo.e-mentio.ed parameters were no. different amo.g the gro.ps except fo. cyclin D1 levels. Cyclin D1 expressio. was fo.nd to.be stro.g in patients with treated estradio. valerate. Co.clusio.s: The effects o. estro.en o. cyclin D1 expressio. were no. detected with tibo.o.e o. with the additio. o. pro.estero.e to.estro.en in the vaginal epithelium. Cyclin D1 appeared to.have stro.ger effects o. the estro.en related pro.iferatio. co.pared to.apo.to.ic markers in vaginal epithelial cells.