摘要：The development of automation,the Internet of Things(IoT),artificial intelligence(AI),big data,and other digi-tal technologies has made it imperative for pharmaceutical companies to undergo digital transformation to improve their research and development capabilities,increase the quality of their products,lower operating costs,and gain a competitive *** of the most crucial steps in the life-cycle riskman-agement chain for drugs is digital quality assurance(DQA).Based on a literature review,questionnaire survey,and expert consensus,a panel of experts was convened in Shanghai to generate a set of conceptual,pharmaceutical manufacturing-specific DQA *** goal of the consensus is to advance common practices that use digital tools to quickly collect,record,evaluate,and review particular forms of data to enhance the automation of quality assurance and make drug quality activities more efficient.

摘要：剖析中考历史试题命制背后的学理依据、伦理考量及审核标准,是保障考试公正性、教育功效及文化承传的关键所在。高质量的中考历史命题需要关注试题的学理深度、伦理导向性、格理严谨度。学理深度指命题要致力于知识、能力与素养的立体整合,确保历史教育涵盖广泛的知识点,深化学生的学习体验,锤炼其高级思维技巧,促进其全面发展;伦理导向指命题要强调知识传授与价值引导的共进,借助历史案例引导学生形成健康的价值观,达成知行合一,涵养良好品性;格理严谨指命题要兼顾规范性与创造性,严格遵循标准基础上鼓励创新,保证历史命题既有权威性又能激发求知欲,体现教育的艺术性和活力。

摘要：人体器官芯片通过在微流体芯片上构建微缩组织或器官来模拟人体组织或器官的结构、功能及微环境.人体器官芯片研究的提出,为药物临床前试验中动物模型的低通量、高花费、跨物种差异、重现性差等问题提供了解决方案,或将成为下一代通用体外评价模型.本文综述了人体器官芯片的类型与特征,总结了人体器官芯片构建的普遍设计思路,并从细胞、芯片材料与加工、微环境构建与器官芯片测量几方面对器官芯片的构建进行技术拆解,最后讨论了目前器官芯片研究所面临的挑战与机遇.

摘要：针对分布式光伏在配电网中的高比例接入带来的电压越限和波动问题,提出了一种基于多智能体安全深度强化学习的电压控制方法。将含光伏的电压控制建模为分布式部分可观马尔可夫决策过程。在深度策略网络中引入安全层进行智能体设计,同时在智能体奖励函数定义时,使用基于传统优化模型电压约束的电压屏障函数。在IEEE 33节点算例上的测试结果表明:所提方法在光伏高渗透率场景下可生成符合安全约束的电压控制策略,可用于在线辅助调度员进行实时决策。

摘要：目的对生物活性支架在骨质疏松性骨缺损修复再生的研究进展进行综述。方法查阅近年关于生物活性支架用于骨质疏松性骨缺损修复的相关文献,总结生物活性支架类型及其修复方法。结果生物活性支架为骨质疏松性骨缺损修复提供了新策略,包括磷酸钙陶瓷支架、水凝胶支架、3D打印生物支架、金属支架、聚合物支架和骨类器官等,均表现出良好的骨修复促进作用。然而,在骨质疏松症病理骨微环境中,单一材料支架在促进骨再生方面的能力有限。因此,生物活性支架的设计需综合考虑材料的生物相容性、机械性能、生物活性、骨传导性和成骨诱导性。此外,通过物理、化学表面修饰与先进生物技术手段有助于改善成骨微环境,促进成骨细胞的分化。结论随着科技的进步,3D生物打印、骨类器官等技术与先进生物技术的协同应用,有望为骨质疏松性骨缺损的修复与再生提供更高效的生物活性支架。

摘要：光解速率及其测量技术最早由德国科学家提出,21世纪初Metcon公司开发了光解速率测量仪,该技术在国内得到关注,部分高校和公司对光解速率测量系统开展了研究和开发。国外产品一般体积较大,价格昂贵。国内产品中光谱仪、接收器等核心器件仍依赖于国外进口,易受国外技术封锁影响。在我国“十四五”国家重点研发计划中“大气与土壤、地下水污染综合治理”重点专项对化学气候综合站检测技术与装备需求引导下,研制了测量大气物质光解速率的光谱仪系统,并满足其核心部件国产化的要求。系统采用自主设计的小型光谱仪作为核心部件,配合各向均匀响应的光学接收器,经实验室光学定标后测得各种物质的光解速率。该系统工作波段为285~430 nm,时间分辨率可达0.1 s,可测物质包括NO_(2)、HONO、HCHO、H_(2)O_(2)等,与国外进口测量仪器对比,各气体物质光解速率的测量误差小于5%,相关性均超过0.93。采用该系统在合肥市董铺岛对大气中气体光解速率开展了长时间的连续监测。对NO_(2)光解速率变化趋势以及NO_(2)光解速率与浓度间的相关性进行分析,发现光解反应与驱动光化反应的能量密切相关,晴天的光解速率数值明显高于阴天与雨天。发现NO_(2)光解速率与浓度的积分曲线间存在一种经验公式,相关性大于0.9,可通过测量NO_(2)光解速率对NO_(2)浓度的累积量进行估计。该系统实现了核心部件的国产化,整体结构简单、便携,方便外场试验安装的同时,降低成本,提高经济性。研究为大气污染综合监测治理提供数据支撑,对各地区的环境监测及污染预防具有参考意义。

摘要：In this work,we designed and synthesized a novel naphthalenediimide-based n-type conjugated polymer PNDICI,which bears asymmetric backbone containing a 3-chlorothiophene *** asymmetric structure associated with steric effects of the chlorine atom imparts remarkable solubility to PNDICI in various organic solvents,enabling the fabrication of all-polymer solar cells(all-PSCs)by using an environmentally friendly solvent of *** with a novel pyrrolo[3,4-f]benzotriazole-5,7(6H)-dione based p-type conjugated polymer P2F-Si with deep highest occupied molecular orbital energy level,the resulting d-limonene-processed all-PSCs presents an impressively high open-circuit voltage of approaching 1.0 V,corresponding to a very small energy loss of 0.49 *** further morphology optimization by usingγ-valerolactone,we demonstrated an impressive device efficiency of 4.2%,which is among the best photovoltaic performance of devices processed using d-limonene and comparable to that processed by conventional solvent,suggesting the great promise of using greener solvent for fabricating high-performance all-PSCs.

摘要：设计并搭建了一套基于声光可调谐滤波器(AOTF)的光谱成像系统,该系统主要由前置成像镜头、AOTF、中继转像物镜、CCD相机、AOTF射频驱动器以及上位机组成。系统通过对AOTF的衍射光进行波长扫描,并利用CCD相机进行光谱图像采集,最终生成光谱图像立方体。该系统应用于400~700nm波段范围,光谱分辨率优于1nm,无扫描机械结构,实现了图谱合一。利用此系统进行了外场成像实验,经过0级光干扰抑制方法处理后的成像结果清晰可辨。进一步利用该系统对给定浓度在3.62×1017~1.21×1019molecule/cm2之间的不同NO2样气进行了测量,使用差分吸收光谱算法对所测光谱数据进行反演处理,得到NO2样气的测量浓度,并对测量值与给定值的误差和相关性作出了分析,其误差均在20%范围内,且相关系数为0.99401,表明二者具有良好的相关性,验证了该系统应用于污染气体测量方面的可行性。

摘要：Analyzing the education resource construction and management from knowledge management perspective is the hot spot and focus of current education research. We make the knowledge management concept of knowledge acquisition, knowledge application and knowledge creation as the core throughuot the whole process of homework management activities to realize the optimization of homework management process. It mainly illustrates the sharing design and application of homework digitization resources. The sharing and application of homework digitization resources will promote the accumulation of teaching knowledge, which has a guiding research significance for promoting the use of educational resources, the application of education knowledge and the virtuous cycle of transformation and accumulation.

摘要：利用惠普实验室荷控和磁控两种忆阻器模型设计了一个五阶混沌电路.数值仿真结果表明该电路在参数变化情况下能产生Hopf分岔和反倍周期分岔两种分岔行为,并能产生双涡卷、单涡卷、周期态等不同相轨道.为了验证电路的混沌行为,利用基本元器件设计了惠普实验室荷控和磁控忆阻器模拟器,并将其应用到对所设计电路中进行Pspice仿真,电路仿真结果验证了理论分析的正确性.