摘要：Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe (Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1)) with AIE properties for cancer-targeted imaging. The biotinylated probe 1 can be actively uptaken by the biotin receptor-overexpressing cancer cells, and then “smartly” self-assemble into nanoparticles inside cells and turn the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.

摘要：提出了一种基于一体化结构光纤加速度计的同振式三维光纤矢量水听器。利用质量–弹簧系统的一体化结构设计及其工作原理,研制了基于一体化结构的光纤加速度计。在此基础上,采用推挽式结构和6只光纤加速度计,设计制作了一只同振式三维光纤矢量水听器。利用驻波管比较法和差分延时外差解调技术进行测试,结果表明,该光纤矢量水听器在20~500 Hz频率范围有较平坦的加速度相移灵敏度频率响应。以X通道为例,其平均灵敏度为34.7 dB(re.1 rad/(m·s^(-2))),与声质点振动理论计算结果(36.5 dB)和有限元仿真结果(35.5 dB)接近。

摘要：针对某县城水厂原水Mn^(2+)季节性超标的问题,分析Mn^(2+)超标的原因,根据对我国现行除锰工艺的比较,以及利用水厂现场装置进行的试验成果,确定采用ClO_2氧化、石灰碱液调节原水pH值方案作为去除Mn^(2+)的最终方案,Mn^(2+)被氧化生成的MnO_2沉淀物,通过沉淀和过滤得以去除。经除锰改造后,水厂长期运行稳定。在原水Mn^(2+)含量季节性超标的地表水厂中,二氧化氯除锰方案可以推广应用。

摘要：气冷涡轮叶片结构复杂,高温高速燃气与冷却气体的复合使得叶片的表面温度分布极不均匀.冷效试验是检验气冷涡轮叶片冷效设计优劣的主要方法,也为避免叶片超温提供基础的设计数据,冷效试验过程中涡轮叶片表面的真实温度测量成为关键.薄膜热电偶紧密贴附在被测物体表面,厚度仅为几微米,可以准确、快速地获取涡轮叶片的表面温度信息,是航空发动机高温测试领域急需的关键技术,然而我国至今尚未工程化应用.本文在前期单质型贵金属基薄膜热电偶研究基础上制备了Pt-Ir薄膜热电偶涡轮叶片试验件,标定结果表明薄膜热电偶具有优异的稳定性和测温精度.在高温高压流场环境下开展冷效试验,获得了冷效试验全流程温度数据,薄膜热电偶测温数据整体趋势与环境温度一致.薄膜热电偶测温数据表明,涡轮叶片的表面温度与极近空间内的温度存在明显差异,越靠近涡轮叶片表面温度越低.此外,靠近冷却气膜孔的位置温度较低,叶片尾缘位置温度较高,叶背中间位置的温度变化主要受高温高速燃气的温度影响,叶片尾缘位置的温度变化主要受高温高速燃气流量的影响.本文利用薄膜热电偶实现了冷效试验全过程涡轮叶片表面温度的准确获取,突破了地面试车台叶片冷效试验温度“测不准”或“测不到”的技术瓶颈,该项技术的工程应用将为涡轮叶片冷效正向设计优化、寿命预测、失效分析等提供关键数据支撑.

摘要：Reaction runaway has longtime been an issue in chemical industry as it often leads to severe accidents if not controlled and inhibited *** we have reviewed several key considerations and procedures to prevent such phenomena,including inherently safer reactor design,thermal risk assessment and early warning detection of runaway,and pointed out that the basic principle underlying is necessary heat management and construction of resilient *** inherently safer reactor design,important factors such as heat removal,heat capacitance,flow behaviors and explosive behaviors have been *** survey shows that heat exchanger(HEX) reactor and microreactor outperform traditional ***,we have looked into the effect of thermal risk ranking and safety operation region determining for thermal risk assessment,and the influence of runaway criteria and construction methods for early detection of reaction runaway as *** shows that thermal risk assessment plays a key role on process design,and early warning detection system(EWDS) is preferable on prevention of reaction *** the end,perspectives regarding inherently safer designs with the measures discussed above have been provided.

摘要：数字试验测试验证(Digital Experiment,Testing,and Validation,D-ETV)是利用“数力”和“智力”更好地了解产品或系统基本属性和性能特征的方法,是实现高质高效研制运维的重要支撑手段。然而,在物理试验测试验证(Physical Experiment,Testing,and Validation,P-ETV)向D-ETV演化的过程中,因缺乏基础共性标准参考,导致不同人员对D-ETV的理解与认识存在差异;因缺乏关键技术标准参考,导致D-ETV实现难;因缺乏通用支撑、安全、行业应用等标准参考,导致D-ETV实施难。针对上述问题,首先从D-ETV有何用、如何用、何处用3个角度对D-ETV标准需求进行分析。在作者团队前期提出的D-ETV通用流程“D”模型及关键技术基础上,进一步建立并完善“析-定-建-测-评-融”D-ETV理论体系。面向航空航天、工程机械、船舶、电子信息、汽车等领域的国家重大需求,与相关研究院所和企业共同尝试探索建立一套D-ETV标准体系,包括基础共性、关键技术、通用支撑、安全和行业应用5类标准。期望相关工作为D-ETV理论研究、标准研制、行业应用提供参考,助力我国试验测试验证向数字化、智能化、服务化方向发展,进而为我国装备高质量发展提供支撑。

摘要：为进一步实现在移动设备上对驾驶员吸烟的违法行为实时检测,提出一种改进的SlimYOLOv7-tiny模型。使用DSConv替换YOLOv7-tiny特征融合网络中标准3×3卷积,增加P6检测层,采用Mish激活函数,引入边框回归损失函数EIoU loss,利用Slim剪枝算法进一步提高模型的轻量化,使用PyQt5开发图形界面程序。实验结果表明,模型在自建驾驶员吸烟数据集上与原模型相比参数量减少60.0%,计算量减小64.39%,有利于模型进一步在移动设备及嵌入式设备上的实时性检测。

摘要：探究聚-γ-谷氨酸(γ-PGA)对水稻产量、品质和养分吸收的影响,为高产优质、养分高效利用的水稻栽培技术提供理论依据和技术参考。于2022年和2023年在湖北省武穴市花桥镇开展田间试验,采用随机完全区组设计,包括黑籼稻(B)、冈特优8024(R)和黄华占(H)3个水稻品种,和不施加γ-PGA发酵液(P0)和施加25 kg hm^(-2)γ-PGA发酵液(P1)2种γ-PGA处理方式,分析了水稻干物质量、植株氮磷素积累量、产量、稻米外观品质、籽粒蛋白质含量和直链淀粉含量。结果表明,2022年施加γ-PGA对水稻产量影响显著,P1处理较P0水稻产量增加3.2%~10.8%;2023年施加γ-PGA对水稻产量无显著影响。施加γ-PGA的品种B和R的干物质量显著高于不施γ-PGA处理,BP1处理较BP0齐穗期干物质量显著增加7.5%~8.5%,成熟期干物质量显著增加5.9%~7.2%;RP1处理较RP0齐穗期干物质量显著增加8.5%~8.8%,成熟期干物质量显著增加3.3%~3.5%。施加γ-PGA对品种H的干物质量无显著影响。施加γ-PGA能显著提高水稻的氮素和磷素积累量,P1处理较P0齐穗期氮素积累量显著增加12.5%~19.0%,磷素积累量显著增加13.4%~20.3%;成熟期氮素积累量显著增加7.2%~16.5%,磷素积累量显著增加9.2%~29.0%。施用γ-PGA能显著提高稻米直链淀粉和蛋白质含量,降低胶稠度、垩白度,但对粒长、粒宽、碱消值无显著影响。因此,施用γ-PGA显著提高水稻植株干物质量和氮、磷素积累量,改善稻米品质。

摘要：Due to the current trend towards lightweight design in automotive industry,hollow stepped gear shafts for automobile and its radial forging process are widely *** coupled finite element thermo-mechanical model,radial forging process of a hollow stepped gear shaft for automobile was *** optimal combination of three process parameters including initial temperature,rotation rate and radial reduction was also selected using orthogonal design *** examine the strain inhomogeneity of the forging workpiece,the strain inhomogeneity factor was *** results reveal that the maximum effective strain and the minimum effective strain appeared in the outermost and innermost zones of different cross sections for the hollow stepped gear shaft,*** forging parameters are determined as a combination of initial temperature of 780°C,rotation rate of 21°/stroke and radial reduction of 3 mm.

摘要：本文主要研究我国广告业发展现状及未来发展趋势。首先运用描述性统计方法,对我国广告业的发展现状态势进行分析;其次,对各行业的广告投入现状进行差异化分析;最后,通过建立自回归AR(1)模型,对2015至2017年我国广告业的发展态势进行了预测。