摘要：Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent *** the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in ***,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment *** study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study.

摘要：OverviewThe Research Lab on 3D Bioprinting of Zhejiang University focuses on developing innovative 3D bioprinting equipment and technology for healthcare and biomedical applications, since founded in 2017. To further enhance the international collaboration, a joint international research lab on 3D bioprinting of Zhejiang University and University of Oxford was set up. The lab is based on the State Key Laboratory of Fluid Power and Mechatronic Systems and the Oxford Centre for Tissue Engineering and Bioprocessing. The aim of the lab is to establish a world class research and development platform on 3D bioprinting. The lab has extensive and close collaborations with University of Oxford, University College London and multidisciplinary partners of Zhejiang University.

摘要：Three-dimensional （3D） printing is a novel promising technology based on 3D imaging and layer-by-layer additive fabrication. It has a profound influence on all aspects of our lives and is playing an increasing important role in many areas including engineering, manufacturing, art, education and medicine. ＂3D bioprinting＂ has been put forward with the technical progress in 3D printing and might be a possible way to solve the serious problem of human organ shortage in tissue engineering and regenerative medicine. Many research groups flung them into this area and have already made some gratifying achievements. However, it is a long way to fabricate a live organ. Many elements lead to the limitation of 3D bioprinting. This review introduces the background and development history of 3D bioprinting, compares different approaches of 3D bioprinting and illustrates the key factors of the printing process. Meanwhile, this review also points out existing challenges of 3D bioprinting and has a great prospect. Some points proposed in this review might be served as reference for the research of this field.

摘要：优化光模块的发射光信号眼图性能和接收信号灵敏度是提升高速光网络单元(ONU)光模块传输链路预算的关键所在。设计了一种具备高速性能的25G ONU光模块,首先深入研究了高速信号线走线阻抗不连续点的处理技巧和印刷电路板(PCB)打孔工艺设计对传输信号线带宽性能的影响机制,然后调整参考叠层结构、优化过孔工艺方式,最后对其进行高速信号仿真试验分析。测试结果表明:所设计的模块不仅全面满足发射眼图性能和接收灵敏度的指标要求,而且其性能余量远超IEEE802.3ca协议标准。

摘要：文章结合物联网技术与现代农业生产设计了基础大棚生态环境的检测系统,其核心为基于LoRa(Long Range)的无线数据传输。系统选择TPYboardv102作为核心板,通过各类传感器采集环境数据,从而控制大棚内的灌溉系统、卷帘、风扇等设施,并且通过显示器外显各项数据,实现对大棚的智能控制。

摘要：滨海城市大连不仅有地域特色的本土民居,并且有大量外来文化影响形成的舶来民居。该文通过理论分析和实际测量计算,归纳日系文化影响下形成民居的建筑空间中的被动式设计策略,同时对本土化绿色建筑的设计提供新思路。

摘要：从传统民居营建体系中的气候适应性策略入手,通过物理环境实测与软件模拟验算,判定传统民居空间形态的被动式气候调节效果,探究建筑空间与气候之间的关联影响机制,为以空间为核心的绿色建筑设计方法提供参考及依据。

摘要：随着绿色建筑的广泛应用,重技术、轻文化的现象日益明显。本文针对这一现象,从地域文脉的观念制度和器物切入,从自然观念、营建技术和空间组织三个方面总结传统建筑中蕴含的绿色营建智慧,并将其与当代绿色建筑结合,为基于文脉传承的当代绿色建筑的设计方法提供了研究思路。

摘要：文章针对围合式空间形态,以气候适应性空间策略为切入点,通过实测数据与能量流的模拟数据对比,以量化语言研究围合式空间形态的被动式调节作用,为围合式空间形态的被动式调节作用提供实证依据,旨在为今后的建筑设计及实践提供借鉴。

摘要：目的增加聚醚醚酮(PEEK)卡环臂进入倒凹的比例,并探究这一改变对PEEK卡环固位力和疲劳性能的影响,提出并验证一种可以提高PEEK卡环性能的设计方式。方法设计并加工3组PEEK三臂卡环(n=10/组),分别令其固位臂的末端1/3、末端2/3以及全部固位臂进入0.75 mm深度的倒凹;一组钴铬合金卡环(n=10),令其固位臂末端1/3进入0.25 mm深度的倒凹作为对照组。在对卡环进行初始固位力测量后,在体外进行15000次摘戴的疲劳循环,每经过1500次循环再测量一次卡环的固位力。使用光学扫描与软件偏差分析,通过均方根(RMS)比较疲劳前后卡环的形变量。使用扫描电子显微镜观察疲劳前后卡环臂内表面的变化。结果固位臂全进入倒凹区的PEEK卡环平均固位力(9.24±1.78)N,在3组PEEK卡环中最高;但仍略低于钴铬合金卡环(11.88±2.05)N。经过疲劳循环,各组卡环的固位力均发生了下降,其中钴铬合金卡环固位力的下降率最高(38.38%)。三组PEEK卡环的RMS没有统计学差异(P=0.111),且都低于钴铬合金卡环的RMS(105.47±10.82)μm。在扫描电子显微镜成像下,所有组卡环臂内表面都观察到了磨损的痕迹,并且主要发生在卡环臂进入倒凹的部分。结论增加PEEK卡环固位臂进入倒凹的比例能够有效提高卡环的固位力,并且在经过体外疲劳循环后,具有优于钴铬合金卡环的固位力稳定性,可以满足临床要求。初步验证了通过增加PEEK卡环臂进入倒凹的比例来提高卡环性能的可行性。