摘要：Objective: The aim.of this.s.udy was.to determ.ne whether circulating HLA-G levels. early in pregnancy, predict the s.bs.quent developm.nt of preeclam.s.a (PE). s.udy des.gn: Plas.a s.m.les. collected longitudinally during the firs., s.cond, and third trim.s.ers. from.12 PE patients.and 12 m.tched control patients.were tes.ed for HLA-G protein us.ng a validated s.ndwich ELIs.. Res.lts. Firs. and s.cond trim.s.er HLA-G levels.in PE were s.gnificantly lower than in control patients.(firs. trim.s.er, 1.25 μ g/m. vs.1.95 μ g/m., P = .029; s.cond trim.s.er, 1.11 μ g/m. vs.1.90 μ g/m., P = .024). Conclus.on: Our res.lts.indicate that HLA-G levels.in plas.a from.wom.n who s.bs.quently develop PE are lower than control patients. as.early as.the firs. trim.s.er. This.s.gges.s.that determ.nation of circulating HLA-G protein concentration m.y be us.ful as.an early predictor for the developm.nt of PE.