摘要：A series of new 6-substituted 3 H-quinazolin-4-ones（3 a-3 d） were designed, synthesized and evaluated as the type I positive allosteric modulators（PAMs） of human α7 n ACh R expressed in Xenopus ooctyes by two-electrode voltage clamp. However, no compound showed a better efficacious PAM than lead compound 2 in the presence of acetylcholine（100 μM）. The structure-activity relationship（SAR） analysis suggested that thiazolo[4,5-d]pyrimidin-7（6 H）-one was the key biological skeleton.

摘要：随着老龄化问题的严重,老年人生活自理能力障碍发生的可能性不断增大,对辅助器具的需求量也在不断增加。笔者以在日本参与辅助器具开发的经验为基础,总结在辅助器具开发中遇到的问题,阐述在辅助器具开发过程中引入肢体姿态测定方法的必要性。然后以上肢辅助器具的开发作为切入点,对当下几种获取肢体运动信息的技术手段进行整理对比,尝试为今后相关方面的辅助器具开发与评价提供新的方法和思路。

摘要：Rational designs of electrocatalytic active sites and architectures are of great importance to develop cost-efficient non-noble metal electrocatalysts towards efficient oxygen reduction reaction(ORR)for high-performance energy conversion and storage *** this work,active amorphous Fe-based nanoclusters(Fe NC)are elaborately embedded at the inner surface of balloonlike N-doped hollow carbon(Fe NC/Csphere)as an efficient ORR electrocatalyst with an ultrathin wall of about 10 *** evaluated for electrochemical performance,Fe NC/Csphere exhibits decent ORR activity with a diffusionlimited current density of~5.0 mA/cm^(2)and a half-wave potential of~0.81 V in alkaline solution,which is comparable with commercial Pt/C and superior to Fe nanoparticles supported on carbon sheet(Fe NP/C sheet)*** electrochemical analyses combined with electronic structure characterizations reveal that robust Fe-N interactions in amorphous Fe nanoclusters are helpful for the adsorption of surface oxygen-relative species,and the strong support effect of N-doped hollow carbon is benefitial for accelerating the interfacial electron transfer,which jointly contributes to improve ORR kinetics for Fe NC/Csphere.

摘要：以童装为研究对象,通过市场调研及案例分析,梳理分析科技元素在童装品牌中的应用形式、面临的挑战及发展趋势,并针对科技元素在童装品牌中的应用提出建议,以期为相关从业者进行设计创新提供一定的新思路,最后进行了将科技元素运用到童装设计的具体实践。研究表明,科技元素运用于童装品牌中需要结合消费者需求、重视其实用价值;进一步的设计实践说明科技元素在童装设计中的应用是多学科、多领域的交叉融合。

摘要：在产品开发与产品性能评价中经常会使用到观察法,随着人工智能人体姿态识别技术的发展,可以大幅度提升对肢体动作的量化效率。文章以笔记本改良为研究对象,通过使用二维姿势检测系统,采集使用者在翻动笔记本动作时肢体关键位置信息,帮助产品开发者有效地发现传统行为观察法难以发现的动作细节,探索新的客观评价方法,促进产品开发时的更迭速度。

摘要：日常生活中包含了很多与他人之间的相互行为,相互行为分析研究中经常会用到对身体运动和对话互动的微观分析。文章以JENGA游戏为研究对象,通过尝试多拍摄角度,使用二维姿势检测系统OpenPose获取人体关键点坐标信息,对比不同拍摄角度下所获取的关键点的信任度,抽取信任度高的关键点作为分析对象,以此探索多人场景下的人体姿态数据化分析方法,为行为观察法提供客观的量化分析手段,丰富姿态捕捉技术的应用场景。

摘要：薄壁结构零件被广泛应用在汽车、航空、航天、造船、家电、机械等制造行业。特别是计算机辅助设计与制造技术的发展,使得机械设计及制造领域对复杂零件的加工制造等都实现了良好的现代化。文章以金属薄壁件烟灰缸为例,通过并结合烟灰缸的设计要求进行加工工序设计以及加工工艺的处理优化和UG仿真建模等,实现了良好的尺寸协调性,使薄壁件的加工技术在一定程度上有所突破。

摘要：在一些四足爬行平台机械结构基础上,设计出四足平台机械结构。通过分析和计算,并应用Pro/E软件绘制出零部件,将其虚拟装配后实现运动仿真,做出样机。

摘要：设计不同试验方案,使用10%PAG淬火液和空气作为淬火介质对40Mn钢带进行淬火试验,将完成淬火的钢带与未淬火的钢带进行拉伸试验和硬度测试,并使用金相显微镜观察了钢带的金相组织。通过数据对比发现,以空气为淬火介质的40Mm钢带在淬火温度为840℃时获得的钢带性能最佳,其抗拉强度为752.5 MPa,硬度为289.3HV0.2,金相显微组织为细小的珠光体和铁素体。使用PAG淬火液作为淬火介质时,40Mn钢带在淬火温度为840℃时获得的试样性能最好,其抗拉强度为1682.9 MPa,硬度为623.8 HV0.2,金相显微组织主要为马氏体和少量残余奥氏体。将经空气和PAG淬火液淬火后获得的试样参数与原材料试样的参数比较后可得:经空气淬火后,试样性能略有提升;经10%PAG淬火液淬火后,试样性能显著提升。

摘要：Most people explain“Nei Juan”based on the connotation of the“Involution”and other fierce competition outlined ***,the misunderstanding of the term triggers adverse social anxiety and stigmatizes reasonable education *** result of“Nei Juan”is that everyone screws more effort to expect the raised standard,but no one yields better returns due to the fixed *** essay related to the education-oriented examination in China reveals the adverse effects of“Nei Juan,”focuses on why the public misunderstand the“Nei Juan”as involution and distinguishes it from the positive *** the term’s connotation is responsible for helping those escaping from the futile effort and relaxing from the rat race.