摘要：Oral administration is the best way for the most patients due to the good compliance,and intestinal epithelium is the main barrier of oral drug *** order to overcome the small intestine epithelial barrier to orally deliver water-insoluble drugs,deoxycholic acid(DA),a substrate of the intestinal bile acid transporters,conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)(DA-PEOz-PLA)was designed and synthesized,and deoxycholic acid-modified polymeric micelles composed of DA-PEOz-PLA and mPEG-PLA were fabricated to encapsulate model drug coumarin 6(C6)based on intestinal bile acid *** structure of DA-PEOz-PLA was confirmed using 1 H NMR and TLC,and the molecular weight measured by GPC was 10034 g/mol with a PDI of *** C6-loaded polymeric micelles with drug loading content of 0.085%were characterized to have 40.11 nm in diameter and uniform spherical morphology observed by ***,the deoxycholic acid-modified polymeric micelles were demonstrated to further enhance the transmembrane transport *** mechanic study evidenced that anchorage of deoxycholic acid onto the micelles surface enriched their transcellular transport ***,the designed deoxycholic acid-modified polymeric micelles might have a promising potential for oral delivery of water-insoluble drugs.

摘要：随着信息科技的快速发展,移动支付、可信云计算、区块链等新技术的推出,中央银行发行的传统纸质货币面临着许多新的挑战,数字货币可能成为未来货币发行、支付模式的发展方向。本文在理论层面,梳理了数字货币概念、理念发展,总结了理想的数字货币需要具备的特征;在技术层面,在对区块链技术进行辩证分析的基础上,提出数字货币系统应兼收并蓄包括区块链在内的各种成熟技术;在实践层面,在总结若干需要重点考虑问题的基础上,提出了构建中国法定数字货币的设计要点。

摘要：为对复合材料加筋板的稳定性和承载能力作简便、快捷的评估,建立一种针对多种组合形式的复合材料加筋板稳定性分析的工程计算方法。基于分段处理法,设计工程计算方法总体框图;基于经典层合板理论,计算各单层刚度系数;利用等效刚度法、有效宽度法等计算方法,建立加筋板的等效刚度矩阵模型和各屈曲模式下的屈曲载荷和破坏载荷计算相关的数学模型参数。设计该工程计算方法的计算程序流程,并利用MATLAB开发软件工具,实现参数化、自动化的屈曲模态判断和屈曲载荷、破坏载荷的预估计算。给出求解算例,将计算结果与试验和有限元分析结果进行对比分析,验证该方法的正确性和精确性。

摘要：Powered lower limb exoskeletons have traditionally used four or more powered joints to provide ambulation assistance for individuals with spinal cord *** with numerous powered joints commonly lost some excellent features of passive orthoses and further decreased utility due to added weight and increased control *** work adopts joints coupling mechanism to design a powered exoskeleton to minimize the number of actuated joints and control *** conventional powered exoskeletons,the joint-coupled-powered exoskeleton only has a single motor-actuated joint for each exoskeleton leg in conjunction with a unique knee coupled system to enable their users to walk,sit,and *** two types of joint coupled systems are designed,respectively,hip-knee coupled and knee-ankle *** joint-coupled-powered exoskeleton system allows a single actuator to power the hip motion,and allows activate knee motion through the coupled motions of the hip or *** specifically,when the mechanical coupled system is activated,the knee joint is unlocked,resulting in synchronized hip-knee or ankle-knee flexion and *** coupling mechanism is switched on and off at specific phases of the gait(the stance phase and the swing phase)to generate the desired *** research work proves that minimal actuated robotic systems with joint coupled could achieve safe and natural walking.

摘要：介绍了中国散裂中子源/快循环质子同步加速器射频同步相位环路的数字化控制系统设计方案,并利用ALTERA公司的现场可编程门阵列开发面板进行了系统开发,完成了控制回路的编程与仿真,进行了桌面实验和低功率实验,并对其进行了分析与讨论。实验结果表明:同步相位环路运行稳定,控制误差小于1°,满足物理设计要求。

摘要：RNAscope是以新型探针设计为优势的新一代原位杂交技术,现正逐步应用于多个研究领域,研究范围亦在不断拓展之中。我国肝病人口基数大,基于组织学生物信息检测及研究评价的需求性大,该技术有独特原位水平的特异性与敏感性,弥补了免疫组织化学与传统原位杂交的技术缺陷。实现多重性及单分子水平检测,可在肝病领域多个方面进行核酸水平的定性、定量分析并与组织原位结合实现可视化评价以凸显"金标准"的价值。现就近年来RNAscope技术在肝脏组织学方面的应用进行综述。

摘要：在聚变堆氦冷固态包层氚增殖区,球床通道内氦气流动压降特性对泵功率的设计具有重要意义。以氦冷固态包层氚增殖区为背景,研究了氦气流速、球床颗粒直径及球床通道长度对球床通道内氦气流动压降特性的影响。实验段采用20 mm×20 mm×500 mm的矩形通道,实验中氦气流速为0.1~0.6m/s,球床颗粒直径为0.5、0.8、1.0、1.5、2.0mm。实验结果表明,压降与氦气流速以及球床通道长度呈正相关,与球床颗粒直径呈负相关。对比Ergun关系式发现,在球床颗粒直径较小时,Ergun关系式预测值低于实验值,这主要是由于氦气可压缩性的影响。通过动量方程,理论推导出经可压缩性修正的Ergun关系式,结果发现修正后的Ergun关系式预测值与实验值符合良好。本研究为氦冷固态包层氚增殖区设计提供了数据支撑,为球床通道内流动特性的数值模拟提供了验证手段。

摘要：在对我国寒冷地区涎流冰病害传统处理方法分析的基础上,针对吉林敦化抽水蓄能电站上下水库连接路施工过程中出现的多处山坡涎流冰病害,分析了涎流冰产生的原因,根据路堤、路堑及低填浅挖路基不同部位的特点,拟定了相应的处理方案,通过4年的运营,效果良好。

摘要：老旧小区改造旨在满足人民对美好生活的向往,而老旧小区体检评估则是实现这一目标的重要前置条件。通过梳理和总结北京市石景山区老旧小区体检评估的实践经验,从老旧小区体检评估的困境出发,探讨其优化路径,包括:第一,广泛引入专业力量,以提高体检评估的科学性和可靠性;第二,设计主创人员参与体检评估工作,做好体检评估与改造实施设计的全面衔接;第三,进一步明确参与各方主体工作职责以及合作关系,以促进各主体间的紧密合作与协同;第四,完善信息平台以实现数据和信息的有效管理和共享等,以期为地方政府科学制定老旧小区体检评估方案提供优化思路。

摘要：为了精准识别和评估城市低效用地,提升城市现有土地利用效率,文章采用标准差椭圆分析、核密度分析法和GIS加权叠加分析方法,对张家口市桥东区低效用地进行了识别与再开发潜力测算研究.分析结果表明:(1)桥东区低效用地图斑数量较少,但面积占比较大,主要为工业用地和城镇住宅用地;(2)桥东区低效用地主要集中在三个区域:桥东区与桥西区交界处、桥东区北部和空港经济开发区,具有一定的空间聚集的特征;(3)桥东区低效用地再开发潜力较大,其中住宅用地和工业用地的再开发潜力最大.因此,相较于传统的低效用地识别与再开发潜力测算方法,多源数据的应用将大幅提升低效用地识别与再开发潜力测算的精确性和科学性,并具有较强的可操作性.