摘要：Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal *** of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

摘要：本研究探索中国高校大学生选择学习六个非英语第二、第三公共外语的多语动机构成,并进行跨语言比较。研究采用序贯混合法设计,对289名某高校大学生发放动机问卷,并抽取其中27名学生进行后续访谈。量化数据使用因子分析、多元方差分析和单因素方差分析等手段,质性数据使用NVivo 12.0进行主轴编码。结果显示,受试选修非英语外语的最大动机来源是学习经历,其次是文化兴趣和自我区分。在工具型动机、融合型动机、自我区分、文化兴趣四个变量间存在显著跨语言差异。本研究也表明,中国学习者拥有模糊的多语姿态,同时受到全球英语的过滤效应影响。多语动机的跨语言差异体现宏观语言价值体系对社会语言使用和语言教育系统的渗透,凸显了语言学习动机和社会政治文化环境之间的共生关系。本文最后对如何开展"多语并进"的外语教育改革提出了实施建议。

摘要：X射线聚焦望远镜是进行空间X射线观测的核心设备,为保证其观测结果的准确性,需要对进入聚焦镜的低能电子进行有效偏转,达到降低本底噪声的目的.本文针对增强型X射线时变与偏振空间天文台(enhanced X-ray timing and polarimetry mission,eXTP)聚焦镜电子偏转器研制工作,满足聚焦镜光学系统对于低能电子的偏转需求,兼顾轻量化、电子偏转能力以及电磁兼容性能等问题,采用有限元分析软件COMSOL Multiphysics建立了电子偏转器及聚焦镜镜片的全物理仿真模型,分析了磁感应强度分布、电子偏转轨迹以及磁场对聚焦镜镜片的影响,完成了电子偏转器电磁参数设计.模拟结果表明,电子偏转器周围空间中磁感应强度沿半径方向减小,两根辐条正中间磁感应强度最大值可达0.027 T.在磁感应强度平面及纵向分布中,当半径大于280 mm或纵向距离大于60 mm时,磁感应强度小于5×10^(–5)T(0.5 Gs),满足电磁兼容性能设计要求.当入射角≤10°时,电子偏转效率随电子能量和入射角增大而减小,50 keV能量以下电子偏转效率可达100%,满足电子偏转设计要求.聚焦镜镜片底端距离电子偏转器130 mm时,聚焦镜镜片在磁场的作用下,应力大小仅为10^(–3)N/m^(2)量级,形变大小仅为10^(–5)nm量级,表明磁场不会对聚焦镜的光学性能产生影响.这些结果为eXTP聚焦镜电子偏转器的研制工作提供了重要参考.

摘要：通过比较国内外高强度螺栓设计计算方法的异同 ,指出了传统螺栓计算方法在确定螺栓预紧力、螺栓应力分类以及确定螺栓载荷等方面存在的不足 ,并试图给出一个适合我国螺栓材料的螺栓设计方法供设计人员计算。

摘要：旨在探讨不同基质、不同激素及其浓度对茵芋扦插成活率的影响,以便筛选出最佳扦插基质、激素及其浓度组合,为茵芋驯化与产业化开发提供理论依据。采用16种基质、5种激素种类及其浓度三因素析因设计,研究各因素及其交互作用对茵芋扦插育苗的影响。试验结果表明:不同基质、激素及其浓度对提高茵芋扦插成活率影响效应明显,扦插基质对成活率影响最大,激素其次,激素浓度影响相对较小。16种基质类型中,珍珠岩30%+泥炭40%+河砂30%混合基质的扦插成活率最优。激素类型中,对茵芋扦插成活率影响效应依次为IAA>IAA+NAA>IBA+NAA>IBA>NAA,IBA+NAA和IAA+NAA的混合激素没有明显组合效应。激素浓度中,IBA+NAA、IBA、NAA的不同激素浓度间的差异显著或极显著,浓度效应为浓度升高则成活率降低,IAA+NAA和IAA在不同浓度水平间的差异不显著;但是,清水对照的茵芋扦插成活率最高、平均成活率89.84%,则茵芋组织器官受机械损伤后具有较强的内源激素形成能力。茵芋扦插繁殖的最优措施为清水浸泡穗条和采用珍珠岩+泥炭+河砂(3:4:3)混合基质;次优方案为珍珠岩+泥炭+河砂(3:4:3)混合基质,配合实施浓度为400 mg/L的IAA激素;河砂基质配合实施浓度为400 mg/L的IAA激素,也是经济实用方案。

摘要：为了解决在制备大尺寸碘化钠晶体过程中可能存在的安全问题,特别是高温环境下晶体制备装置可能产生的化学原料挥发问题,需要设计安全联锁控制系统,以保障试验人员的安全。采用可编程逻辑控制器(PLC)作为主要控制装置,辅以其他监测设备,设计了试验厂房的安全联锁控制系统方案。该系统采用巡检联锁、浓度监测装置联锁以及南北两侧门装置联锁技术,具备操作对象锁定、设备运行状态监测和区域进入限制功能。设计完成后,对联锁系统进行了搭建,并对制备过程中可能遇到的危险情况进行了模拟。在模拟过程中,安全联锁控制系统取得了良好的运行结果,使系统的可行性和可靠性得以验证。该安全联锁控制系统的设计方案对于化工试验安全生产过程具有可靠性,为类似试验的安全设计提供了有效的设计方案。

摘要：Objective To develop RT-nPCR assays for amplifying partial and complete VP1 genes of human enteroviruses(HEVs)from clinical samples and to contribute to etiological surveillance of HEV-related *** A panel of RT-nPCR assays,consisting of published combined primer pairs for VP1 genes of HEV A–C and in-house designed primers for HEV-D,was established in this *** sensitivity of each RT-nPCR assay was evaluated with serially diluted virus stocks of five serotypes expressed as CCID50 perμL and copies perμL,and the newly established methods were tested in clinical specimens collected in recent *** The sensitivity of RT-nPCR assays for amplifying partial VP1 gene of HEVs was 0.1 CCID50 perμL and 10 virus copies perμL,and for the complete VP1 gene was 1 CCID50 perμL and 100 virus copies perμL,using serially-diluted virus stocks of five *** a proof-of-concept,25 serotypes were identified and complete VP1 sequences of 23 serotypes were obtained by this system among 858 clinical specimens positive for HEVs during the past eight surveillance *** This RT-nPCR system is capable of amplifying the partial and complete VP1 gene of HEV A–D,providing rapid,sensitive,and reliable options for molecular typing and molecular epidemiology of HEVs in clinical specimens.

摘要：We present a semi-custom design methodology based on transistor tuning to optimize the design performance. Compared with other transistor tuning approaches, our tuning process takes the cross-talk effect into account and prominently reduces the complexity for circuit simulation and analysis by decomposing the circuit network utilizing graph theory. Furthermore, the incremental placement and routing for the corresponding transistor tuning in conventional approaches is not required in our methodology, which might induce timing graph variation and additional iterations for design convergence. This methodology combines the flexible automated circuit tuning and physical design tools to provide more opportunities for design optimization throughout the design cycle.

摘要：As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap *** particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ *** by the editorial board of Bio-Design and Manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable *** further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control ***,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.

摘要：针对罗茨风机用双端面机械密封在运行中常出现的失效情况进行了总结和分析,找出了引起密封失效的主要原因,并从密封设计选材、日常维护等角度提出了具体解决措施,能够为相关机械密封的设计、使用以及的运行维护提供有效的参考。