摘要：A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.

摘要：Dynamically crosslinked materials generally lose their self-healing ability and mechanical robustness in aqueous,acidic,and basic environments due to disruption of their dynamic interactions and ***,a micelle-like structure with a hydrophobic outer layer is used to protect ionic *** structure ensures the self-healing and long-term stability of the ionically crosslinked elastomers in aqueous,acidic,and basic *** elastomer possesses a tensile strength of 6.7 MPa and a strain at break of 1400%,which is superior to the existing waterproof selfhealing *** strain sensors and dielectric actuators based on the elastomer are highly stable and self-healable,even in extremely harsh *** design strategy of hydrophobic protection for dynamic interactions is quite general,allowing it to be extended to other self-healing materials.

摘要：碳纤维增强塑料筋(CFRP筋)因其耐腐蚀等优点被应用于组合梁。现在研究其耐火性能的计算一般认为混凝土没有开裂,与实际情况存在差别,并带来安全问题。本文基于ISO834标准升温曲线模拟CFRP组合梁在室内火灾下的情况,考虑CFRP筋组合梁在弯曲荷载和温度荷载共同作用下的耐火极限和受力分析。通过建立火灾下考虑裂缝影响的CFRP筋组合梁热力耦合模型,得到裂缝对不同保护层厚度、配筋率和作用荷载比的CFRP筋混凝土梁耐火极限的影响规律,总结出CFRP筋组合梁的防火相关设计建议。

摘要：A predominance area diagram for the Zr-Si-C-O system at 1773 K was plotted according to correlative thermodynamic data. β-SiC/ZrO2 composites were prepared based on the phase diagram by carbothermal reduction of zircon （ZrSiO4） in argon atmosphere. Zircon and carbon black were mixed according to the C/ZrSiO4 mass ratio of 0.2, and with 0, 1wt% and 2wt% extra addition of La2O3. Phase evolution of the mixture was investigated at 1723-1803 K by X-ray powder diffraction, and the microstructure of the product prepared at 1803 K for 4 h was examined by scanning electronic microscope. The results show that the decomposition of ZrSiO4 and the formation of β-SIC can be promoted by increasing the heating temperature and adding La2O3. The β-SiC/ZrO2 composites can be prepared at 1803 K for 4 h in a mixture of zircon, carbon black and La2O3, and the contents of β-SIC and m-ZrO2 in the product sample with 2wt% La2O3 reach the highest values of 10.8wt% and 89.2wt%, respectively. The crystal size of the products is about 200 nm.

摘要：Using an optical vortex coronagraph （OVC） is one of the most promising techniques for di- rectly imaging exoplanets because of its small inner working angle and high throughput. This paper presents the design and laboratory demonstration performance of an OVC based on liquid crystal polymers （LCPs） at 633 nm and 1520 nm. The OVC can deliver good performance in laboratory tests and achieve a contrast of 10-6 at an angular distance of 3A/D, which can be implemented for imaging young giant exoplanets in combination with extreme adaptive optics.

摘要：混凝土是建筑和基础设施建设中最广泛使用的材料之一,其生产过程会导致大量的碳排放。计算混凝土的碳排放是评价和实施低碳的关键,也是混凝土质量发展的重要内涵。基于此,重点关注混凝土材料的生产碳排放,从混凝土生产碳排放的计算方法出发,讨论了生产过程的低碳措施,综述了混凝土生产中的相关减碳研究和应用,期望从混凝土材料设计和生产角度为混凝土行业实现低碳生产提供参考。

摘要：Nanofibers can mimic natural tissue structure by creating a more suitable environment for cells to grow,prompting a wide application of nanofiber *** this review,we include relevant studies and characterize the effect of nanofibers on mesenchymal stem cells,as well as factors that affect cell adhesion and osteogenic *** hypothesize that the process of bone regeneration in vitro is similar to bone formation and healing in vivo,and the closer nanofibers or nanofibrous scaffolds are to natural bone tissue,the better the bone regeneration process will *** general,cells cultured on nanofibers have a similar gene expression pattern and osteogenic behavior as cells induced by osteogenic supplements in *** involved in cell adhesion(focal adhesion kinase(FAK)),cytoskeletal organization,and osteogenic pathways(transforming growth factor-β(TGF-β)/bone morphogenic protein(BMP),mitogen-activated protein kinase(MAPK),and Wnt)are upregulated *** adhesion and osteogenesis may be influenced by several *** possess certain physical properties including favorable hydrophilicity,porosity,and swelling properties that promote cell adhesion and ***,nanofiber stiffness plays a vital role in cell fate,as cell recruitment for osteogenesis tends to be better on stiffer scaffolds,with associated signaling pathways of integrin and Yes-associated protein(YAP)/transcriptional co-activator with PDZ-binding motif(TAZ).Also,hierarchically aligned nanofibers,as well as their combination with functional additives(growth factors,HA particles,etc.),contribute to osteogenesis and bone *** summary,previous studies have indicated that upon sensing the stiffness of the nanofibrous environment as well as its other characteristics,stem cells change their shape and tension accordingly,regulating downstream pathways followed by adhesion to nanofibers to contribute to ***,additional experiments are needed to id

摘要：文化创意产业作为城市发展的新引擎,是未来城市竞争的核心领域。作为文化强国战略建设的重要领域,我国城市文化创意园区的建设发展取得了一定成效,但仍然面临同质化竞争、动力不足、特色不突出等问题,需要开展系统性规划方法研究以推动其高质量发展。立足于公园城市理念,以山水人城和谐相融新实践为统领,从生态环境、发展动力、营城模式、现代治理等角度探讨文化创意城区的规划策略,并以成都天府数字文化创意城为例进行实证研究,以期为国内外文化创意城区的规划建设提供借鉴。

摘要：目的分析文字在视觉传达设计中形意构建的双重性问题。方法以文字设计应用为线索,通过设计实践的符号学分析,从语义与形式两个层面进行文字内在属性、结构与功能的探讨。结论文字在视觉信息构建与媒体传播中具有语言和图形表达的双重身份,这是由文字语言符号形式与语义的双重属性决定的,同时也是语言性文字透过图形化视觉表现的必然结果。这决定了文字在视觉信息传播中形意相生的基本结构,并呈现出语言的文字与艺术的图像之间的共生关系。它既可以是传播本体的语言表述方式,也担负着喻体象征的视觉艺术功能,极大地拓展了视觉传达设计的创造空间与可能。

摘要：背景:青少年腰椎间盘突出症是引起青少年腰疼的主要病因,目前绝大多数患者通过保守治疗干预,而当长期的非手术治疗尝试后,患者的症状没有得到充分缓解或者当患者出现神经麻痹或马尾神经受压的症状时,手术可能是防止进一步损伤的必要手段,而选择合适的椎间融合器至关重要。目的:探究青少年腰椎间盘突出症患者置入不同高度微创椎间融合器固定后对腰椎生物力学的影响。方法:采集一名17岁男性青少年腰椎间盘突出症患者(L4-5节段突出)的CT扫描资料,MIMICS三维重建后,选择用与实验对象椎间隙等高和高于椎间隙3 mm椎间融合器进行分析,设计重建两种可膨胀混合材料椎间融合器:融合器L前高11 mm、后高9 mm、宽9 mm、长28 mm;融合器H前高14 mm、后高11 mm、宽11 mm、长28 mm,并对腰椎融合器进行建模。将融合器与腰椎模型经过优化处理,逆向建模后导入ABAQUS并最终得到腰椎融合三维模型。模拟人体腰椎后伸、前屈、右侧弯、左侧弯等生理活动,得到相应应力云图,观察L4-5椎体在7种不同工况下的生物力学特征。结果与结论;(1)两种融合器终板最大应力均在前屈和后伸工况,前屈工况H融合器上、下终板应力值为(18.27±3.80)MPa和(15.02±3.24)MPa;L融合器上、下终板应力值为(9.16±0.05)MPa和(9.17±1.83)MPa;后伸工况H融合器上、下终板应力值为(19.11±4.03)MPa和(16.32±3.72)MPa;L融合器上、下终板应力值为(9.13±0.01)MPa和(4.92±1.01)MPa;(2)除中立位L5上终板,其余不同工况下H型融合器终板应力值均大于L型融合器终板,差异有显著性意义(P<0.05);(3)同一椎间隙中选择高度超过椎间隙高度3 mm的椎间融合器更稳定。