摘要：The thioredoxin system plays a role in a variety of physiological functions, including cell growth, differenti- ation, apoptosis, tumorigenesis, and immunity. We previously confirmed that butaselen （BS）, a novel thioredoxin reductase inhibitor, can inhibit the growth of various human cancer cell lines, yet the underlying mechanism remains elusive. In this study, we investigated the anti-tumor effect of BS in vivo through regulating the immune system of KM mice. We found that BS inhibits tumor proliferation by promoting the activation of splenic lymphocytes in mice. BS can elevate the percentage of CD^4-CD8^＋ T lymphocytes and the secretion of downstream cytokines in mice via downregulating the expression of programmed death-ligand 1 （PD-L1） on the tumor cells＇ surface in vivo. Further study in HepG2 and BEL-7402 cells showed that decrease of PD-L1 level after BS treatment was achieved by inhibiting signal transducer and activator of transcription 3 （STAT3） phosphorylation. Taken together, our results suggest that BS has a role in promoting the immune response by reducing PD-L1 expression via the STAT3 pathway, and subsequently suppresses tumorigenesis.

摘要：本文利用基于国际上非常流行开源软件R和python进行实验设计给出圆周率的实验设计让同学们感受学习概率论与数理统计如何解决实际问题,这样的实验课教学实验设计教学都有非常好的借鉴意义,还探讨了软件在概率论与数理统计课程实验教学中应用有几个应该注意问题,这些都有利于概率论与数理统计教学效果的提高和教学目标的实现。

摘要：通过推导并构建包含生产与生活和空间效应的因素分解模型,利用1980—2015年全国及省际面板数据,量化分析了技术水平、产业结构、生活用能强度和地区经济规模变动对中国能源强度的影响。结果表明,除生产部门的技术进步之外,生活用能强度降低是持续引领中国能源强度下降的又一个重要因素;产业结构调整在1985年以后产生了负面影响;地区经济规模变动在2005年之后产生了消极影响。从省际层面看,存在的问题有:新疆的技术水平倒退,内蒙古和海南的生活用能强度上升,多数省市产业结构和经济规模的变动影响消极等。因此,降低中国的能源强度,除了依赖于技术进步和优化产业结构外,还需提高生活部门的用能效率,促进区域经济和能源利用的协调发展。

摘要：针对危险警示栏收放的三自由度收放机构的运动控制问题,基于S7-200PLC核心控制器,采用继电器分时控制与传感器限位保护,设计收放机构的收放控制硬件电路;给出一个收放运动控制算法,并经过软件编程调试实现收放机构三自由度平稳直线运动的手动及自动控制。对收放机构控制的实验测试表明,该控制电路的设计以及控制算法是合理可行的。

摘要：河流交汇区是河网系统中水、沙、污染物、生物等环境要素的突变点,也是河网行洪与污染物输移扩散的关键控制节点。从野外测量、室内试验与数值模拟方面,总结分析了河流交汇区水流结构与污染物输移的基本特征及其在不同交汇条件作用下的响应规律,以及复杂水流结构与生境对于河流交汇区水安全的重要影响。展望了未来研究重点,建议加强非恒定流条件下的交汇区水力学特性研究,进一步揭示交汇区污染物掺混输移特征与水动力条件之间的响应机制,研究通过工程布局与水力优化调控相结合的措施系统提升了交汇区防洪安全与水生态环境质量。

摘要：Single-component anode materials can barely satisfy the growing demand for next-generation Li-ion batteries with higher capacity and cyclability. Thus developing multi-component synergistic electrodes has become a critical issue. Herein, inspired by natural corn, a ternary hierarchical self-supported array design is proposed. Based on a sequential transformation route, Si/C-modified C0304 nanowire arrays are constructed on 3D Ni foams to form a binder-free integrated electrode. Specifically, an ionic liquid-assisted electrodeposition strategy is employed to prepare discrete ultrafine Si nanoparticles on nanoscale array substrates, which follow the Volmer-Weber island growth mode. In this corn-mimetic system, kernel-like Si nanoparticles and a husk-like carbon coating layer function as enhancing and protecting units, respectively, to improve the capacity and stability of the cobalt oxide basic unit. Taking advantage of a synergistic effect, the ternary nanoarray anode achieves a significant performance enhancement compared to pristine Co304, showing a special capacity as high as -1,000 mAh·g^-1 at 100 mA·g^-1. By extending this corn-mimetic hierarchical array design to other basic, enhancing, and protecting units, new ideas for constructing synergistic nano-architectures for energy conversion and storage field are developed.

摘要：针对近年来安全带引发的汽车事故及现有安全带的缺陷问题,本文基于普通安全带结构和功能分析的基础上,设计了一种汽车智能安全带,该安全带具备芯片读卡与警示、安全带心率检测、车辆距离预警防护及碰撞保护功能,同时确定了智能安全带整体设计方案及系统工作原理,为驾乘人员提供更安全的保障。

摘要：随着信息安全威胁的日益增多和复杂化,从传统监控向可观测性的转变已成为不可避免的趋势。为有效应对信息系统在故障检测、性能优化和安全管理等领域的问题,设计并实现了B/S架构下前后端分离的可观测性系统。系统主要功能包括四项:一是数据收集。通过对日志、指标与追踪三种数据的收集实现对软硬件层面的全方位监控。二是数据处理。通过日志处理与数据聚合实现对收集到的数据进行有效的管理与分析。三是数据存储。通过存储与管理日志数据、性能指标和追踪数据,为系统的监控、分析和优化提供支持。四是数据可视化。通过交互式监督与实时数据展示来设置监控指标并了解系统健康状态。系统应用于中国铁路哈尔滨局集团有限公司研发并运维的信息系统,应用结果表明:该系统能够快速识别并诊断潜在问题,提高信息系统的可靠性,优化信息系统的性能。

摘要：Polyl(lactide),PLA,suffers from bitleness and low heat deflection temperature(HDT),which limits its application as an engineering *** this work,poly(L-lactide)/poly(D-lactide)/ethylene-vinyl acetate glycidyl methacrylate random copolymer(PLLA/PDL A/EVM-GMA=1/1/x)composites were prepared by melt blending,and the in situ formed EVM-g PLA copolymers improved the compatibility between PLA and ***,the blends were subjected to a two-step annealing process during compression molding,*** annealing at 120℃ to rapidly form a certain amount of stereocomplex(sc)crystallites as nucleation sites,and then annealing at 200℃ to guide the formation of new *** differential scanning calorimetry(DSC)and wide angle X-ray dffrction(WAXD)measurements confirmed the formation of highly stereocomplexed PLA *** results showed that the PLLA/PDLA blend with 20 wt%of EVM-GMA had a notched impact strength up to 65 kJ/m2 and an elongation at break of 48%,while maintaining a tensile strength of 40 ***,dynamic mechanical analysis(DMA)and heat deflection tests showed that the PLA composite had an HDT up to 142℃ which is 90℃ higher than that of normal PLA *** electron microscopy(SEM)confirmed the fine dispersion of EVM-GMA particles,which facilitated to understand the toughening ***,the highly stereocomplexed PLA composites simultaneously exhibited excellent chemical and hydrolysis ***,these fascinating properties may extend the application range of sc PLA material as an engineering bioplastic.

摘要：为明确纤维与粉土对水泥稳定风积沙的增强效果,对不同纤维掺量、粉土掺量、养护龄期下的试样进行抗压强度试验,并通过扫描电镜(SEM)和核磁共振(NMR)试验对试样的微观结构特点进行了表征。结果表明,纤维与粉土的加入能有效提高试样的抗压强度;养护龄期与试样强度增长为正相关关系;最佳纤维掺量和最佳粉土掺量分别为2%、15%;在此掺量下,养护28 d试样的强度达到1.68 MPa,相比于水泥稳定风积沙的强度(0.45 MPa)提高了3.73倍。扫描电镜结果表明,试样强度提升来源于纤维在试样中的空间交织作用以及粉土的填充效应。核磁共振结果进一步表明,纤维的加入可降低试样中大孔与中孔的比例,其中2%纤维掺量的降低幅度最大。该研究结果可为风积沙地区路基的施工与设计提供有效参考。