摘要：Microfluidic device with patterned microstructures on the substrate surface was used to regulate cell adhesion,morphology,and functions in tissue *** developed a microfluidic device which employing microscale patterned microstructures to achieve enhanced cell adhesion and *** hydrogel substrates with micro-wavy and lattice-patterned microstructures were fabricated using standing surface acoustic waves and ultraviolet *** seeding the L929 mouse fibroblast cells onto the patterned substrate of the microfluidic device,we determined that the viability and proliferation rate of cell migration can be greatly ***,L929 cells showed two types of gathering modes after 48 h of *** growth was guided by the patterned substrate used in the microfluidic device and showed differences in the location ***,the developed microfluidic device with patterned microstructures can extend the application of in vitro cell culturing for future drug development and disease diagnosis.

摘要：有机合成化学是高校化学类本科生的一门专业选修课。自由基化学是有机化学学科中非常前沿的研究领域。针对当前学生在基础有机化学中自由基化学知识构建缺失的现状,提出以“立德树人”的课程思政为指引,以“深度学习”为目标,以“科学前沿”的中国自信为背景的互动教学,在合成化学课程中设计自由基反应相关知识模块,从自由基的引入、深化、拓展及不对称自由基反应的应用等多方面深度学习,凝练合成化学课程思政元素,建构思政案例库,为本科阶段有机合成化学教学与课程思政相结合提供新的视角。

摘要：We discuss the P-V criticality and phase transition in the extended phase space of Born-Infeld AdS(BIAdS) black hole surrounded by quintessence dark energy, where the cosmological constant Λ is identified with the thermodynamical pressure P. Comparing with Van der Waals(VdW)-like SBH/LBH phase transition of Born-Infeld AdS(BI-AdS) black hole, we find that the BI-AdS black hole surrounded by quintessence dark energy possesses lower critical temperature because of parameter a > 0, even disappears since the parameter a taking enough large values leads to Tc ≤ 0. Moreover, the interesting thermodynamic phenomenon of reentrant phase transition(RPT) are also observed,and the quintessence dark energy plays a similar role in this RPT.

摘要：Chiral cyclic amino alcohols with contiguous stereocenters are key building blocks in the synthesis of bioactive molecules and *** cascade biocatalysis represents an attractive method for the synthesis of chiral molecules bearing multiple stereocenters from readily available *** we reported an artificial cascade biocatalysis comprising an epoxide hydrolase,an alcohol dehydrogenase,and a reductive aminase or an amine *** can be utilized to access all four stereoisomers of 2-aminocyclohexanol with two contiguous stereocenters in high yields(up to 95%)and excellent stereoselectivity(up to 98%de)starting from readily available cyclohexene oxide without isolation of the ***,the biocatalytic cascade has been successfully extended to the production of structurally diverse 2-(alkylamino)cyclohexanols by replacing ammonia with different organic amines.

摘要：The accuracy of spot centroid positioning has a significant impact on the tracking accuracy of the system and the stability of the laser link *** satellite laser communication systems,the use of short-wave infrared wavelengths as beacon light can reduce atmospheric absorption and signal ***,there are strong non-uniformity and blind pixels in the short-wave infrared image,which makes the image distorted and leads to the decrease of spot centroid positioning ***,the high-precision localization of the spot centroid of the short-wave infrared images is of great research significance.A high-precision spot centroid positioning model for short-wave infrared is proposed to correct for non-uniformity and blind pixels in short-wave infrared images and quantify the localization errors caused by the two,further model-based localization error simulations are performed,and a novel spot centroid positioning payload for satellite laser communications has been designed using the latest 640×512 planar array InGaAs shortwave infrared *** experimental results show that the non-uniformity of the corrected image is reduced from 7%to 0.6%,the blind pixels rejection rate reaches 100%,the frame rate can be up to 2000 Hz,and the spot centroid localization accuracy is as high as 0.1 pixel point,which realizes high-precision spot centroid localization of high-frame-frequency short-wave infrared images.

摘要：Microorganisms have been the main sources for the production of *** of chemicals requires the development of low-cost and higher-yield *** this goal,microbial strains with higher levels of production should be first *** engineering has been used extensively over the past two to three decades to increase production of these *** in omics technology and computational simulation are allowing us to perform metabolic engineering at the systems *** combining the results of omics analyses and computational simulation,systems biology allows us to understand cellular physiology and characteristics,which can subsequently be used for designing ***,we review the current status of metabolic engineering based on systems biology for chemical production and discuss future prospects.

摘要：受航天器体积和重量限制,航天星载遥感探测系统难以兼顾大口径、高分辨率以及高光谱信息同步获取的需求。针对这一问题,本文提出一种新型的高光谱成像系统,采用主次镜共用、多通道分离同轴五反光路设计,结合Offner凸面光栅光谱仪分光技术,实现从可见到长波红外的高光谱探测。该系统主镜口径为1000 mm,在500 km轨高下,可见和短波、中波、长波、全色波段空间分辨率分别优于2 m、3 m、6 m和1 m。且系统全视场可达到2.3°,满足20 km幅宽的探测要求。为提高系统的像差与畸变校正能力,设计中引入高阶非球面,形成像方远心光路,实现了望远镜与光谱仪的光瞳匹配。此外,本文还将光谱仪模块整体放入冷箱制冷,从源头上抑制光机结构背景辐射对成像质量的影响。最终设计结果表明,该系统成像质量优良、布局简单且体积轻便,而且能够实现全谱段高光谱信息的同步获取,可广泛应用于星载对地探测成像等领域。

摘要：螺旋管束由于其结构紧凑、传热效率高等特点广泛应用于快堆与第4代核电堆型中。为揭示螺旋管束流体弹性不稳定性,本文在验证激振模型的冲击实验基础上,利用螺旋管束激振模型系统地研究了管的相对位置、管束结构参数对螺旋管振动响应的作用机制。研究发现面外方向的振幅远大于面内方向的,相邻管层节径比对螺旋管振动响应的影响强于同层管间节径比与螺旋角。通过改变管间流速,探究了螺旋管束流体弹性不稳定性机理,提出了预测临界流速的半经验公式,并且同现有直管管束的国家标准与先前的研究成果进行了对比分析,结果为螺旋管式蒸汽发生器的设计与工程评估提供了理论基础。

摘要：北京市国民经济和社会发展第十一个五年规划纲要的报告，明确提出文化创意产业将是北京市未来的工作重点，北京将成为文艺演出、出版发行、影视制作、动漫和网游、文化会展和古玩艺术品交易中心。为了响应北京文化创意产业战略，北京电影学院动画学院首先发起了“中国原创动漫之旅”的活动，并在活动中召开了围绕创意文化产业而进行的创作和教育两个论坛。“动漫创作论坛暨文化创意产业论坛”主要注重的是原创与艺术的结合，讨论艺术创作，其中不单是商业形式上的创作，同样注重艺术方面的讨论，给创作者们提供了一个双向交流的平台，可以让他们在祥和的气氛中交流创作经验。“动漫教育论坛”主要注重的是面对动漫市场异常激烈的人才竞争，如何培养动画漫画方面原创人才，突出人才的培养要从未来产业发展的需求作为切入口，培养出具有原创性的动漫人才，真正推动我国动漫产业的发展。

摘要：在过去的百年间,从德国包豪斯到荷兰风格派,都对现代工业设计的形成与发展产生了极其深远的影响。曾有人说:“荷兰人用设计造就了荷兰。”大到城市、建筑,小到电器、家具,设计已融入到荷兰人生活的方方面面,并成为推动荷兰工业社会发展的重要助力。