摘要：The peroxisome proliferator-activated receptors （PPARs）, PPARt,, PPARβ/δ and PPARy, are ligand-activated transcriptional factors, which belong to the nuclear receptor super family and play crucial roles in glucose and lipid metabolism. Based on the impressive advantages ofPPAR agonists （like TZD and fibrate compounds） in the treatment of metabolic syndrome and type 2 diebetes, PPAR modulators have doubtlessly grabbed much more attention. However, serious clinical adverse effects, especially for PPARy agonists, hinder the development of PPAR agonist, Therefore, the selectivity and safety would be the key points and have been taken into the consideration for novel generation PPAR agonist research, and then several dual- or pan-PPAR modulators have emerged. Furthermore, experimental study indicates that partial agonists can neutralize the side effect and achieve modest therapeutic effect. This review summa.ies structural features of PPAR receptors, illustrates the method of PPAR modulator design, then lists and analyzes recent dual- and nan- agonists