摘要：Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.