摘要：Mandibular defect occurs more frequently in recent years,and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic *** engineering,which is a hot research field of biomedical engineering,provides a new direction for mandibular defect *** the basis and key part of tissue engineering,scaffolds have been widely and deeply studied in regards to the basic theory,as well as the principle of biomaterial,structure,design,and fabrication ***,little research is targeted at tissue regeneration for clinic repair *** mandibular bone has a special structure,rather than uniform and regular structure in existing studies,a methodology based on tissue engineering is proposed for mandibular defect repair in this *** steps regarding scaffold digital design,such as external shape design and internal microstructure design directly based on triangular meshes are discussed in *** analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping,the feasibility and effectiveness of the proposed methodology are properly *** works about mechanical and biological improvements need to be done to promote its clinical application in future.

摘要：In maxillofacial surgery, there is a significant need for the design and fabrication of porous scaffolds with customizable bionic structures and mechanical properties suitable for bone tissue engineering. In this paper, we characterize the porous Ti6Al4V implant, which is one of the most promising and attractive biomedical applications due to the similarity of its modulus to human bones. We describe the mechanical properties of this implant, which we suggest is capable of providing important biological functions for bone tissue regeneration. We characterize a novel bionic design and fabrication process for porous implants. A design concept of “reducing dimensions and designing layer by layer” was used to construct layered slice and rod-connected mesh structure (LSRCMS) implants. Porous LSRCMS implants with different parameters and porosities were fabricated by selective laser melting (SLM). Printed samples were evaluated by microstructure characterization, specific mechanical properties were analyzed by mechanical tests, and finite element analysis was used to digitally calculate the stress characteristics of the LSRCMS under loading forces. Our results show that the samples fabricated by SLM had good structure printing quality with reasonable pore sizes. The porosity, pore size, and strut thickness of manufactured samples ranged from (60.95± 0.27)% to (81.23±0.32)%,(480±28) to (685±31)μm, and (263±28) to (265±28)μm, respectively. The compression results show that the Young’s modulus and the yield strength ranged from (2.23±0.03) to (6.36±0.06) GPa and (21.36±0.42) to (122.85±3.85) MPa, respectively. We also show that the Young’s modulus and yield strength of the LSRCMS samples can be predicted by the Gibson-Ashby model. Further, we prove the structural stability of our novel design by finite element analysis. Our results illustrate that our novel SLM-fabricated porous Ti6Al4V scaffolds based on an LSRCMS are a promising material for bone implants, and are potential

摘要：Mandibular defect occurs more frequently in recent years,and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic *** engineering,which is a hot research field of biomedical engineering,provides a new direction for mandibular defect *** the basis and key part of tissue engineering,scaffolds have been widely and deeply studied in regards to the basic theory,as well as the principle of biomaterial,structure,design,and fabrication ***,little research is targeted at tissue regeneration for clinic repair *** mandibular bone has a special structure,rather than uniform and regular structure in existing studies,a methodology based on tissue engineering is proposed for mandibular defect repair in this *** steps regarding scaffold digital design,such as external shape design and internal microstructure design directly based on triangular meshes are discussed in *** analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping,the feasibility and effectiveness of the proposed methodology are properly *** works about mechanical and biological improvements need to be done to promote its clinical application in future.

摘要：荧光各向异性方法又称荧光偏振法,基于相互作用的分子结合前后发射光退偏振的不同而实现对相互作用的研究或对目标物的检测。20世纪50年代Gregorio Weber用荧光各向异性法研究了氮磺酰氯与牛血清白蛋白和卵清白蛋白的作用,开启了该方法在生物化学研究中应用的先河。而20世纪90年代开始的功能性核酸(FNAs,包括核酸适配体和核酸酶等)的发现与合成,使基于功能性核酸的传感得到了广泛的应用。核酸适配体能够特异性识别目标分子,基于核酸识别的荧光各向异性分析方法具有高选择性、高灵敏度、高通量等优势,在研究蛋白质、核酸和小分子的相互作用中起到重要作用,然而如何提高结合前后的荧光各向异性信号变化,尤其是小分子识别前后,在基于功能性核酸识别的分析方法发展中是一个挑战。介绍了基于功能性核酸识别的荧光各向异性的方法应用于检测蛋白质、核酸及其他在生命活动中起重要作用的小分子的基本原理及设计理念。

摘要：毕业设计是培养学生工程实际应用能力和创新意识的重要实践性教学环节,在本科教育中占有非常大的比例。同时,校企联合指导毕业设计的教学模式是本科生教学的发展趋势。本文针对建筑环境与能源应用工程专业的应用特点,提出了校企联合指导建环专业毕业设计的教学模式。

摘要：为探究紊动对水体中溶氧释放的促进效果,设计以潜水泵排水的方式,开展了不同水泵数量、功率、摆放方式、排水方向等工况下过饱和溶氧释放过程研究试验。结果表明,紊动对水体中溶氧释放有较好的促进效果。放入5个泵(功率20 W、纵向排水)时,水体溶氧释放系数为0.514 h^(-1),是未放入水泵时溶氧释放系数0.026 h^(-1)的19.77倍。当水泵垂直于水面排水时,溶氧释放效果较好。水泵个数越多、功率越大,溶氧释放系数越大,溶氧释放效果越好。

摘要：A conventional Fowler flap is designed to improve the take-off and landing performances of an aircraft. Because the flight states of general aviation aircraft vary significantly. A Fowler flap with a double-sliding track has been designed, which is ca- pable of changing airfoil camber while cruising and climbing as well as meeting low-speed performance requirements. The aerodynamic characteristics of the variable camber Fowler flap were studied by computational simulation, and cambering was found to be beneficial for improving the lift-to-drag ratio when the lift coefficient was larger than the critical value, below which decambering was more effective; this critical value differed somewhat under different conditions. Taking the mecha- nism into account, the take-off and landing configurations were optimized on the basis of the GA （W）-1 airfoil with a 30% chord Fowler flap. Compared with reference configuration, the maximum lift coefficient of optimized take-off configuration was increased by 6.6% as well as the stalling angle and the lift-to-drag ratio were increased by 1.3° and 7.58%, respectively. Moreover, the maximum lift coefficient of the optimized landing configuration was increased by 6.3%, and the stalling angle was increased by 1.1°; however, the nose-down pitching moment of both configurations increased. Similar results were at- rained on a general aviation aircraft wing/body combination nism was established in a computer-aided design system, achieved by the double-sliding track. A 3D model of the variable-camber Fowler flap driving mecha- and the results showed that all design configurations could be

摘要：A three-layered phosphor structure was designed and prepared by the spin coating of BaSi_(2)N_(2)O_(2):Eu(cyan-emitting)and(Sr,Ca)AlSiN_(3):Eu(red-emitting)phosphor films on the yellowemitting Y_(3)Al_(5)O_(12):Ce(YAG:Ce)phosphor ceramic synthesized by the solid-state reaction under vacuum *** order to achieve high color rendering lighting,the influence of the composition and structure of the three-layered phosphors on the optical,thermal,and electrical properties of the chip-on-board(COB)packaged white-light-emitting diodes(WLEDs)was studied *** WLED with the structure of“red+cyan+yellow”(R+C+Y)three-layered phosphor generated neutral white light and had a luminous efficacy of 75 lm/W,the fidelity index(R_(f))of 93,the gamut index(R_(g))of 97,and the correlated color temperature(CCT)of 3852 *** the excitation of laser diode(LD),the layer-structured phosphor yielded the white light with a luminous efficacy of 120 lm/W,color rendering index(CRI)of 90,and CCT of 5988 *** result indicates that the three-layered phosphor structure is a promising candidate to achieve high color rendering and high luminous efficacy lighting.

摘要：采用压裂技术提升煤层气储层渗透性是强化煤层气开发的重要途径。对于深部高温煤层气储层,液氮压裂技术通过在煤层中注入低温液氮形成显著热应力,基于冷冲击作用可实现对煤层气储层的致裂增渗。为研究液氮作用对高温煤岩的力学特性及损伤破裂特征的影响机制,对加热至不同温度条件下的煤样进行液氮冷却处理,通过波速测试和巴西劈裂测试,研究液氮对高温煤样波速、强度、声发射和裂纹演化等特征及破裂模式的影响机制。结果表明:高温煤样在液氮冷却作用后,力学性能出现了显著劣化,P波波速降低,超声频率分化严重,主频由51.10 kHz降至40.88 kHz。煤样逐渐由脆性破坏向延性破坏转变,巴西劈裂模量和脆性指数降幅最高分别为67%和75%。在巴西劈裂荷载下,煤样内部声发射信号均表现为低RA值、高AF值;煤样内部破坏形式主要为拉伸破坏,其次为剪切破坏。随着煤样初始温度的增加,煤样断裂面上形成多个起伏区域,3维形貌扫描的最大波峰与最大波谷高度差最高可达37.60 mm。液氮冷却诱导的微裂隙交叉扩展形成复杂的裂纹网络,进而导致局部失效区域的形成和煤样断裂面复杂化。表观裂纹分形维数在初始加热温度为100℃时达到最大值,由初始20℃时的0.50增加到1.83。研究结果可为深部高温煤层液氮压裂设计提供理论参考。

摘要：This paper focuses on the fast rate fault detection filter (FDF) problem for a class of multirate sampled-data (MSD) systems. A lifting technique is used to convert such an MSD system into a linear time-invariant discrete-time one and an unknown input observer (UIO) is considered as FDF to generate residual. The design of FDF is formulated as an H∞ optimization problem and a solvable condition as well as an optimal solution are derived. The causality of the residual generator can be guaranteed so that the fast rate residual can be implemented via inverse lifting. A numerical example is included to demonstrate the feasibility of the obtained results.