摘要：Bone is an essential organ for health and quality of *** to current shortfalls in therapy for bone tissue engineering,scientists have sought the application of synthetic materials as bone graft *** a composite organic/inorganic material with significant extra cellular matrix(ECM),one way to improve bone graft substitutes may be to engineer a synthetic matrix that is influenced by the physical appearance of natural ECM *** this work,the authors evaluate composite,hybrid scaffolds for bone tissue engineering based on composite ceramic/polymer microsphere scaffolds with synthetic ECM-mimetic networks in their pore *** thermally induced phase separation,nanoscale fibers were deposited in the pore spaces of structurally sound microsphere-based scaffold with a density proportionate to the initial polymer *** and mechanical testing indicated no significant changes in overall pore characteristics or mechanical integrity as a result of the fiber deposition *** scaffolds displayed adequate mechanical integrity on the scale of human trabecular bone and supported the adhesion and proliferation of cultured mouse calvarial *** from natural cues,these scaffolds may represent a new avenue forward for advanced bone tissue engineering scaffolds.