摘要：Angiokinases, such as vascular endothelial-, fibroblast-and platelet-derived growth factor receptors(VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great success in recent years. In this study, we presented the design, synthesis, target identification, molecular mechanism, pharmacodynamics(PD)and pharmacokinetics(PK) research of a novel triple-angiokinase inhibitor WXFL-152. WXFL-152,identified from a series of 4-oxyquinoline derivatives based on a structureeactivity relationship study,inhibited the proliferation of vascular endothelial cells(ECs) and pericytes by blocking the angiokinase signals VEGF/VEGFR2, FGF/FGFRs and PDGF/PDGFRβ simultaneously in vitro. Significant anticancer effects of WXFL-152 were confirmed in multiple preclinical tumor xenograft models, including a patientderived tumor xenograft(PDX) model. Pharmacokinetic studies of WXFL-152 demonstrated high favourable bioavailability with single-dose and continuous multi-dose by oral administration in rats and *** conclusion, WXFL-152, which is currently in phase Ib clinical trials, is a novel and effective tripleangiokinase inhibitor with clear PD and PK in tumor therapy.

摘要：Contemporary folk dance in Xuzhou is deeply influenced by Chu- Han culture,presenting some clear regional characteristics of Chu-Han culture like valuing ritual,grandeur,humanist spirit of enterprising and pursuing *** order to promote the healthy development of contemporary folk dance in Xuzhou,and realize the interaction with Chu-Han culture,it is of great significance to create Chu-Han brand culture,to build dialogue mechanism with folk dancing culture in Xuzhou,to make connection with Chu- Han culture industry,and to fully express the artistic features of dance then in this area etc.

摘要：The mammalian target of rapamycin(mTOR) is a critical component of the PI3K-AKT signaling pathway. It is highly activated in cervical cancer, which continues to pose an important clinical challenge with an urgent need for new and improved therapeutic approaches. Herein, we describe the structure-based drug discovery and biological evaluation of a series of m TOR kinase inhibitors as potential anti-cervical cancer agents. The results of enzymatic activity assays supported C3 as a potential m TOR inhibitor, which exhibited high inhibitory activity with an IC50 of 1.57 μM. Molecular docking and dynamics simulation were conducted to predict the binding patterns, suggesting relationships between structure and activity. The anti-proliferative assay against diverse cancer cell lines was displayed subsequently, revealing that C3 exhibited significant proliferation inhibition against cervical cancer cell He La(IC50=0.38μM) compared with other cell lines. Moreover, C3 could effectively reduce the expression of phospho-ribosomal S6 protein(p-S6) in He La cells in a dose-dependent manner. Noteworthily, m TOR signaling and other cellular pathways might contribute to the significant effect of C3 against cervical cancer simultaneously. These data indicated that C3 represented a good lead molecule for further development as a therapeutic agent for cervical cancer treatment.

摘要：Transmit waveform optimization is critical to radar system performance. There have been a fruit of achievements about waveform design in recent years. However, most of the existing methods are based on the assumption that radar is smart and the target is dumb, which is not always reasonable in the modern electronic warfare. This paper focuses on the waveform design for radar and the extended target in the environment of electronic warfare. Three different countermeasure models between smart radar and dumb target, smart target and dumb radar, smart radar and smart target are proposed. Taking the signal-to-interferenceplus-noise ratio(SINR) as the metric, optimized waveforms for the first two scenarios are achieved by the general water-filling method in the presence of clutter. For the last case, the equilibrium between smart radar and smart target in the presence of clutter is given mathematically and the optimized solution is achieved through a novel two-step water-filling method on the basis of minmax theory. Simulation results under different power constraints show the power allocation strategies of radar and target and the output SINRs are analyzed.

摘要：非正常经营企业的存续,在导致企业间要素生产率分化的同时,会改变市场退出与进入条件,并抑制市场结构调整,引致集约边际与广延边际的资源错配,使行业加总全要素生产率增长受损。以2012—2021年上市公司数据进行实证检验,发现非正常经营企业发生率越高,广延边际与集约边际资源错配越明显,净进入效应与企业间效应的加总全要素生产率增长受损越严重,且这种关系在稳健性检验和内生性检验后仍然存在。异质性分析发现,管制性行业与高污染行业、第二产业与对外开放依赖程度高的地区,受非正常经营企业影响更大。因此,新时代推进高质量发展,应畅通市场退出机制,充分发挥市场在资源配置中的决定性作用。

摘要：电催化作为纳米材料和能源化学领域的研究热点,是未来新能源存储与转化技术的关键所在。在“碳达峰,碳中和”背景下,电催化还原硝酸盐合成氨技术被认为是绿色、安全的技术,为了填补这一前沿科研成果在实验教学中的空白,我们开发了基于电催化还原硝酸盐合成氨的综合化学实验。本实验具有基础知识-科学研究-实际应用的一体化设计,包含铜基催化剂制备表征、性能探究及应用设计的层次化内容,有助于学生了解电催化的研究进展,掌握电催化的基础知识与研究方法,培养学生的创新意识与学以致用的能力。

摘要：基于Hospers创意城市所应具备的集中性、多样性、非稳定状态等三个要素,经过分析和论证,笔者认为,乌鲁木齐具备创意产生的良好基础。乌鲁木齐这个城市的文化与艺术的民族特色和地域特色比较鲜明,城市建设应该立足于历史文化底蕴、民族风情以及中亚视野,积极吸取相近城市和地区的成功经验,通过对创意资源的挖掘、搜集、整理、改造和推广等各个步骤的有序进行,走出一条适合自己的,文化、历史与艺术相结合的,少数民族风情与宗教风俗相结合的,具有多重魅力的创意城市建设道路。

摘要：针对干扰条件下MIMO雷达面临的信号截获以及干扰源快速移动等问题,对雷达收发方向图进行优化设计。在发射端利用最小积分旁瓣准则对发射波束矩阵进行优化,将发射信号能量集中到目标空域,降低旁瓣并在干扰方向形成发射零陷;在接收端利用广义对角加载方法优化接收方向图,在提高信号接收稳健性的同时展宽零陷。通过对MIMO雷达收发方向图进行联合优化设计,解决了信号被截获及快速移动的有源干扰等问题,从收发两端共同提高雷达整体性能。通过实验仿真对比分析,验证了所提方法的可行性和有效性。

摘要：陶瓷是我国的文化名片之一,承载了我国漫长的文化历史和文明发展轨迹,是我们炎黄子孙引以为傲的艺术作品。中国古代除四大发明外,最引人瞩目的便是陶瓷的产生,古人常用“薄如纸,明如镜、声如磐、白如玉”比喻陶瓷的外形,因此陶瓷不仅是一个独特的艺术种类,同时还成为现代的重要工艺装饰品,被广泛应用于环境艺术中。而设计人员则根据陶瓷的耐热性、易清洗、雕塑感强等优点,将其作为环境设计中的主要元素,强化环境设计的艺术效果,优化视觉体验,本文从陶瓷艺术在环境设计中的应用角度出发,旨在优化环境设计效果。

摘要：现有多输入多输出雷达波形设计方法分别对杂波和有色噪声条件下的雷达波形进行了优化,而对实际应用中杂波和有色噪声同时存在的情况,现有方法并不能得到最优波形.针对该问题,提出一种杂波和有色噪声条件下基于互信息量的多输入多输出雷达波形设计方法,该方法综合考虑目标、杂波和有色噪声对波形优化的影响,通过理论推导给出了发射信号矩阵表达式,并给出了目标和杂波特征向量与噪声特征向量之间的匹配顺序,利用注水定理对该匹配顺序下的各天线发射信号功率进行了优化,确定了具体的发射信号矩阵表达式.实验仿真结果表明,当发射功率为10dB时,所提方法的互信息量比一般注水方法和仅考虑目标与噪声匹配顺序的方法分别高8bit和4bit.