摘要：使用DEFORM-3D三维模拟软件对哈氏合金基带的粗轧过程进行多道次仿真,依托流变应力的计算,建立了材料物性模型和仿真模型,并利用前几道次的粗轧实验验证了模型的准确性。通过仿真实验探索了压下率、轧辊形状和摩擦因数对轧制流程的影响。结果表明,随着道次压下率的升高,平均轧制力升高,30%道次压下率的轧制流程带来基带应变不均匀性是表面裂纹产生的重要原因,成功预测了后续轧制实验中带材表面产生的裂纹,实际生产应尽量选用20%及以下的压下率;在该应用条件中,新设计的凹面轧辊流程能有效减小轧制力,降低设备要求,提高轧制安全性,实验中部分流程采用凹面轧辊有效地将侧面裂纹的出现延迟到了第8道次;好的润滑条件能减小摩擦,模拟结果表明摩擦因数越小,基带轧制的均匀性越好,但会增加工序的时间,也会提高材料进给的难度。研究结果优化了实际轧制流程,降低了基带轧制过程中的表面及边部裂纹等缺陷。

摘要：A method based on capillary electrophoresis coupled with amperometric detection（CE-AD） has been developed for the separation and determination of kaempferol,ferulic acid,vanillic acid,caffeic acid,gallic acid and protocatechuic acid in blueberry wine for the first *** order to get the optimum conditions of separation,the effects of working electrode potential,pH value and concentration of running buffer,separation voltage and injection time on CE-AD were *** the optimum conditions, the analytes could be separated in Na_2B_4O_7-KH_2PO_4 buffer at pH 7.8 within 18 min.A 300μm diameter carbon disk electrode had good current responses at ＋0.95 V（***） for all *** responses were linear with concentrations over three orders of magnitude with detection limits（S/N = 3） at 10^（-8） g/mL magnitude for the analytes and the recoveries were in the range of 95.8- 106.7%.The method could be successfully applied to the analysis of real sample with satisfactory results and therefore recommended for use by the quality control departments of fruit wine producers.

摘要：Energetic particle radiation diagnoses mainly detect the particles(such as neutrons,gamma rays,hard X-rays,and escaping electrons)that are radiated in the discharge process of the experimental advanced superconducting tokamak device to characterize the operating state of the plasma in real *** upgrading of these diagnoses requires new instruments based on national(here,“national”means developed and produced by a Chinese company)core chips and open-source software with advanced digitization,a high sampling rate,and a high time *** new spectroscopy system designed in this study adopts the national field-programmable gate array(FPGA)and an analog-to-digital converter as the core chip,and it is developed using Qt on *** communication between the FPGA and embedded controller occurs via a high-speed peripheral component interconnect eXtension for instrument express protocol with a direct memory access *** this basis,the time resolution of the system is improved from 2 to 1 ms,the maximum channel address is increased to 4096,and the sampling rate is increased from 10 to 80 *** experiments of the spectroscopy system with 152Eu and 137Cs sources demonstrate that the best energy resolution is 0.27%and the measurement error is less than±0.5 keV.

摘要：将互动式教学植入课堂教学,将"以教师为中心"的模式转变为"以学生为中心"的模式,强化课堂教学效果,拓展学生的能力。通过设计"水资源利用与保护"课程的课堂互动式教学的具体方法,以学生为主体,把学生推到主角的位置上,让学生"动"起来,让课堂"活"起来,使知识"活"起来。互动式激活了学生的思维,强化了学生的互动能力和合作学习意识,促使学生不断思考,不断发现,逐渐转化为自主学习的学习者,形成"学生带着问题走向课堂"的全新教学局面。结果表明,互动式课堂教学模式激发了学生的学习动机,增强了学生的自信心,拓展了学生对课程知识的实际运用能力。

摘要：针对热噪声试验中石英灯加热器的快速迭代设计和优化的需求,本文简化了行波管模型和噪声气流的模拟方法,基于蒙特卡罗法和热网格方法建立了热噪声试验系统中圆锥形薄壁结构件的热分析模型,获得了圆锥形薄壁结构件在石英灯加热器辐射下的温度分布,并通过与试验数据的对比分析,验证了计算模型的有效性。本文使用的建模方法和热分析模型可用于热噪声试验中类似结构的温度均匀性评估,为石英灯加热器设计和优化提供支撑。

摘要：On the basis of the principle of combination of active groups,a series of novel N-(4-([2,2':5',2''-terthiophen]-5-yl)-2-methylbut-3-yn-2-yl)benzamide derivatives were designed,synthesized and systematically evaluated for their antiviral activity against tobacco mosaic virus(TMV).The bioassay results showed that most of these compounds displayed good anti-TMV activity,and some of them exhibited higher antiviral activity than commercial ***,compound 8e with excellent anti-TMV activity(inactivation activity,92.3%/500μg•mL^(−1);curative activity,85.7%/500μg•mL^(−1) and protection activity,64.7%/500μg•mL^(−1))emerged as a potential inhibitor of plant virus *** structure-activity relationship studies proved that the van der Waals volume(V)and electronic parameter(Σ(Σσo+σp)andΣσm)for the substituent R1 were very important for antiviral activities in this class of compounds.

摘要：Exorbitant aldosterone is closely associated with various severe diseases,including congestive heart failure and chronic kidney *** aldosterone synthase is the pivotal enzyme in aldosterone biosynthesis,its inhibition constitutes a promising treatment for these *** a structure-based approach,a series of pyridyl substituted 3,4-dihydrobenzo[f][1,4]oxazepin-5(2 H)-ones were designed as inhibitors of aldosterone *** compounds(5 j,5 l,5 m 5 w,5 x and 5 y)distinguished themselves with potent inhibition(IC50<100 nmol/L)and high selectivity over homogenous 11β-*** the most promising compound,5 x exhibited an IC_(50) of 12 nmol/L and an excellent selectivity factor(SF)of157,which are both superior to those of the re ference fadrazole(IC_(50)=21 nmol/L,SF=7).Importantly,5 x showed no inhibition against steroidogenic CYP17,CYP19 and a panel of hepatic CYP enzymes indicating an outstanding sa fety *** it manifested satis factory pharmacokinetic pro perties in rats,compound5 x was considered as a drug candidate for further development.

摘要：随着建筑行业的快速发展,EPC项目管理模式正逐渐成为主流。此模式主要特点为包含建设项目的设计、采购及施工,其合同模式体现为固定总价。“窗口期”即项目处于设计阶段,该阶段通常是指项目中标后5个月左右的项目设计阶段。此时项目建设完成后的收款已确定,但建设成本却根据材料价格有浮动。以项目材料价格中波动大、使用量大的钢材作为切入点,通过分析对其不同的价格风险管理措施,对比出各自方案的优势及劣势,以此帮助相关企业更精细化的控制项目成本,以保证企业长久平稳经营。

摘要：让１０个具有不同知识背景和工作经验的被试独立完成一个假设的广告设计任务，要求在设计过程中大声报告他们所想到的内容。根据被试的口语报告，分析广告设计思维的基本过程，并探讨设计者的工作经验和知识背景对设计思维过程的影响。实验结果表明：（１）广告设计活动可以看成是一种问题解决行为，设计要求规定了问题的初始状态和目标状态，设计就是经过一系列认知操作产生出符合设计要求的设计结果；（２）实际工作中的广告设计过程包括问题理解、整体策划以及方案构思等阶段，这种阶段性同样存在于个体的设计思维过程中；（３）由于工作经验和知识背景不同，不同被试的广告设计思维过程具有明显的差异，这些差异体现在使用规则、理解问题以及整体策划等方面。

摘要：以绿茶为研究对象,探究脉冲电场强化提取多糖-多酚复合物(Polysaccharide-polyphenol complex, PS-PP)的方法。基于单因素实验,通过Box-Behnken响应面设计确定脉冲电场强化提取PS-PP的最佳条件,即电场强度为5.3 kV/cm,料液比为1∶30,提取温度为90℃,提取时间为4.5 h,此时复合物的总糖含量为35.70%,多酚含量为9.37%。进一步分析PS-PP的化学成分,结合紫外、红外光谱及扫描电镜等技术表征其结构,发现PS-PP保留了多糖的基本结构,并呈现出多酚的特征峰,提示多糖与多酚之间存在相互作用。研究可为进一步挖掘PS-PP的生物活性及潜在应用奠定基础。