摘要：为构建更为合理的个性化水库水生态安全评价指标体系,以我国东南低山丘陵地区水源地型水库天目湖沙河水库为例,基于2010~2020年逐月水生态监测数据,分析了水库水生态安全状况长期变化特征及影响因素,提出了以满足沙河水库水生态服务功能为目标的生态安全评价方法.结果表明,季节上,夏秋季SD相对较低,而总磷(TP)、浮游植物叶绿素a(Chla)、高锰酸盐指数和蓝藻生物量(BMc)相对较高;空间上,不同区域的水体透明度(SD)存在显著差异(P<0.05),多年均值呈现河流区<过渡区<湖泊区的现象,其他指标均呈现出河流区较过渡区和湖泊区高的现象;垂向上,5~9月随热分层出现,许多指标出现分层,其中异味物质2-甲基异莰醇(MIB)和Chl-a在水深4 m处出现最大值,硅藻生物量(BMb)和BMc最大值分别在水深2 m和0.5 m处出现.基于水生态指标的变化特征认识,应充分考虑水库水生态安全的时空差异性,将水生态安全风险较高的春夏季作为评价期,以Chl-a为核心指标,结合SD和MIB等指标,通过建立关键指标与其他指标的相关关系,构建了沙河水库水生态安全评价体系;评价结果表明,沙河水库10年来水生态安全状况整体优良,但年际波动较大,不同区域的得分差异大,对于存在热分层的区域应采取季节性分3层采样调查数据进行评估.本研究表明在湖库水生态安全管理中选取个性化方案监测评估的必要性;总磷偏高和藻类疯长引发的水体透明度下降和异味物质含量升高是影响亚热带地区水库生态服务功能的主要因素,年际间较大尺度的水文气象条件变化给水库水生态安全带来较大不确定性.

摘要：BOPP微孔薄膜以其制造成本低、无污染等优点被广泛应用于锂电池制造,以其纳米级微孔透过原理,理论上也可应用于过滤、气体透过等领域。究其理论原理,需要在现有设备基础上通过产品工艺优化制备出低密度、大孔径BOPP薄膜是拓展BOPP微孔膜应用领域、提高产品附加值的有效途径。将探讨如何通过产品工艺设计制备低密度、大孔径的BOPP微孔薄膜方法。

摘要：微悬臂梁阵列生物传感器因其强大的适用性和快速响应特性,在无标记生物分子的检测工作中广泛应用。为提高传统微悬臂梁传感器的灵敏度,设计了具有纳米孔洞结构的微悬臂梁,并详细模拟了单个微悬臂梁的固有频率及其在集中载荷作用下自由端的弯曲位移,进一步研究了纳米孔洞结构如何改善微悬臂梁传感器的力学性能,以确定微悬臂梁传感器的最佳纳米孔洞几何参数。结果表明:经过设计改进后的微悬臂梁自由端弯曲位移增加了1.21%。设计的纳米孔洞结构微悬臂梁有效提高了灵敏度,为微悬臂梁的进一步优化设计和工艺改进提供了新的策略。

摘要：目的了解青少年情绪智力的现状并探讨其影响因素,为提高青少年情绪智力水平提供依据。方法采用随机整群抽样方法,以自行设计的调查表、青少年情绪智力量表对1 732名在校中学生进行问卷调查。结果不同性别在情绪智力总得分以及各维度得分比较,差异无统计学意义(P>0.05);是否为独生子女在情绪智力总得分、情绪理解、情绪管理维度得分比较,差异有统计学意义(P<0.05);不同年级、是否担任学生干部在情绪智力总得分以及各维度得分比较,差异有统计学意义(P值均<0.05)。多元线性回归结果表明,年级、是否为独生子女、是否担任学生干部是情绪智力的预测变量(F=37.105,P<0.05)。结论年级、是否为独生子女、是否担任学生干部是情绪智力的影响因素,根据青少年的不同特征进行个体化的健康教育以提高其情绪智力水平。

摘要：根据我国海洋气象测报志愿商船航经中国南部各重要海峡通道时的实测水文气象资料,利用Arc Engine开发一个可视化分析平台,实现船舶实测水文资料的存储管理和空间分析。数据长期累积后可大量补充气象预报参考点,并比对验证局部海区海洋要素的预报,逐步提高预报准确率。

摘要：Receptor-interacting protein(RIP)kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis(UC)by regulating necroptosis and *** group previously identified TAK-632(5)as an effective necroptosis inhibitor by dual-targeting RIP1 and *** this study,using ligand-based substituent-anchoring design strategy,we focused on the benzothiazole ring to obtain a series of TAK-632 analogues showing significantly improving on the anti-necroptosis activity and RIP1 selectivity over *** them,a conformational constrained fluorine-substituted derivative(25)exhibited 333-fold selectivity for RIP1(K_(d)= 15 nmol/L)than RIP3(K_(d)>5000 nmol/L).This compound showed highly potent activity against cell necroptosis(EC_(50)=8 nmol/L)and systemic inflammatory response syndrome(SIRS)induced by TNF-α in ***,it was able to exhibit remarkable anti-inflammatory treatment efficacy in a DSS-induced mouse model of *** together,the highly potent,selective,orally active anti-necroptosis inhibitor represents promising candidate for clinical treatment of UC.

摘要：A variable magnetization(VM) motor by incorporating magnets that can be flexibly configured with variable magnetization process is proposed to meet the emerging requirements on motor efficiency and actuator compliance in robotic applications. A generalized spin torque model is established which provides a relationship between the motor torque and two different types of motor inputs, the current inputs and the magnet magnetizations. Avariable magnetization process is proposed based on the study of the hysteresis properties of the magnetic materials and the design criteria for implementing the variable magnetization process with current pulses are established. The feasibility of the variable magnetization is validated with experimental data and the motor functions and performances are numerically demonstrated and evaluated. The results show that the VM motor can maintain high efficiency by switching between two actuation modes. Controllable stiffness at different equilibria can be also achieved with the VM motor with instantaneous magnetizing current pulses.

摘要：预制混凝土T梁外观质量与梁结构的耐久性和稳定性密切相关,基于此,论文结合依托工程,分析了预制T梁混凝土的外观质量问题,包括混凝土麻面、蜂窝、孔洞、烂边和烂根、气泡以及外观色差等,针对上述外观质量问题,提出了优化混凝土配合比设计,控制混凝土浇筑、拌和及振捣,控制模板安装以及断层面保护层厚度等提升措施。

摘要：The development of automation,the Internet of Things(IoT),artificial intelligence(AI),big data,and other digi-tal technologies has made it imperative for pharmaceutical companies to undergo digital transformation to improve their research and development capabilities,increase the quality of their products,lower operating costs,and gain a competitive *** of the most crucial steps in the life-cycle riskman-agement chain for drugs is digital quality assurance(DQA).Based on a literature review,questionnaire survey,and expert consensus,a panel of experts was convened in Shanghai to generate a set of conceptual,pharmaceutical manufacturing-specific DQA *** goal of the consensus is to advance common practices that use digital tools to quickly collect,record,evaluate,and review particular forms of data to enhance the automation of quality assurance and make drug quality activities more efficient.

摘要：资江特大桥为怀邵衡铁路的重要控制性工程,其中,17#墩位于资江航道内,由12根桩组成,上部由承台连接。墩位的岩溶现象较为发育,呈现出串珠状的分布特征,且各溶洞间的连通性较好,环境复杂,工期紧,技术要求高。根据地质资料、水流方向以及现场勘察确定了岩溶的发育方向,选择冲击钻机从岩溶发育下游逐步向上游施打的打桩顺序。同时采用岩溶注浆将溶腔填注满,再采用抛填片石、钢护筒跟进等方法来处理溶洞。通过采用这些技术措施,成功完成了资江特大桥17#墩的桩基施工,为整个工程的成功推进奠定了基础。