摘要：目的:探讨慢性稳定型心绞痛(CSAP)患者穴位敏化程度与冠脉病变支数的相关性。方法:采用横断面设计,调查CSAP患者近期冠状动脉造影结果,主要为冠脉病变支数。同时使用Von Frey检测器检测疾病相关穴位的压痛阈值,使用有序Logistic回归探讨两者之间的相关性。结果:共纳入166例患者。膻中、阴郄压痛阈值与冠脉病变支数呈负相关(膻中:OR=0.495,95%CI[0.303,0.811];阴郄:OR=0.509,95%CI[0.261,0.992]);督俞的压痛阈值与冠脉病变支数呈正相关(督俞:OR=2.183,95%CI[1.168,4.079])。结论:膻中、阴郄可能是CSAP患者的敏化穴位,未来可进一步在前瞻性高质量的诊断检查中探讨CSAP患者穴位敏化动态变化与疾病严重程度之间的相关性,以期更好地辅助临床诊疗。

摘要：为了保护皮肤健康,特设计开发了核辐射防护服。防护服面料采用双层结构设计,外层经纱和纬纱采用石墨烯聚酯纤维,内层经纱采用石墨烯聚酯纤维,纬纱采用生物基胶原蛋白黏胶纤维。试验结果表明:由三角形截面石墨烯聚酯纤维制成的面料在单粒碘(131I-1)化钠胶囊距织物10cm处的屏蔽率为80.4%;35粒放在织物表面的屏蔽率为56.4%;对氯化锶的吸附率为18.22%,综合防核辐射效果更佳。经检测,此款面料对大肠埃希菌、金黄葡萄球菌、白念珠菌的抑菌率均为99%;对氨气、醋酸、异戊酸、2-壬烯醛的异味成分减少率分别为86.7%、88.0%、98.2%、94.5%,均达到国家标准要求。

摘要：本文结合董家村渡槽施工期工程项目,利用ANSYS有限元软件建立了渡槽施工期仿真计算模型,对埋设在大体积混凝土中的冷却水管的温度场进行计算,并分析水管的布置方式、直径、通水流量、水流速度及冷却水温等因素对温度场的影响。结果显示,在渡槽施工期选择合理的冷却水管布置方案,可以有效降低混凝土中的温度,从而达到防止混凝土产生裂缝的目的。

摘要：Proteolysis targeting chimeras（PROTACs） are bispecific molecules containing a target protein binder and a ubiquitin ligase binder connected by a linker. Recently, some heterobifunctional small molecule bromodomain-containing protein 4（BRD4） degraders based on the concept of PROTACs were designed to induce the degradation of BRD4 protein. Herein, we synthesized a new class of PROTAC BRD4 degraders. One of the most promising compound 22f exhibited robust potency of BRD4 inhibition with IC50 value of （9.4±0.6） nmol/L. Furthermore, com- pound 22f potently inhibited cell proliferation in BRD4-sensitive cell lines RS4;11 with IC50 value of （27.6±1.6） nmol/L and capable of inducing degradation of BRD4 protein at 0.5-1.0 μmol/L in the RS4;11 cells. These data establish that compound 22f is a potent and efficacious BRD4 degrader.

摘要：文创品牌"东方密语"成立于2015年,以深度研究东方文化为基础,通过设计创新,将人文美学价值精炼融入到当代文化创意产品中,同时以全产业链的模式探索文创企业发展新路径。东方密语与甘肃省博物馆、陕西历史博物馆等文博单位合作,陆续推出了"至美敦煌""太初有光""花舞大唐"等系列文创产品,以视觉美、品质美、实用性强、内涵深厚的特点得到了消费者的认可。同时,东方密语对于文创产品背后的历史文化的深入研究,对文化意境与东方美学的多元传达,对于文创开发的审慎态度与责任感,在文创企业中颇具特点。不久前,本刊采访了东方密语的创始人兼设计总监王丽燕,进一步了解东方密语的文创设计理念、经营模式与以及她对文创产业发展的思考。本文在采访的基础上撰写而成。

摘要：Proton exchange membrane fuel cells(PEMFCs)are considered ideal energy‐conversion devices because of their environmentally friendly nature and high theoretical energy ***,cathodic polarization,which is a result of the sluggish oxygen reduction reaction(ORR)kinetics,is a significant source of energy loss and reduces fuel cell ***,the need to use Pt in commercial Pt/C cathodes has restricted their large‐scale application in fuel cells because of its high cost and poor ***,improvements in the activity and durability of Pt‐based catalyst are required to reduce the amount of Pt required and,thus,costs,while increasing the ORR rate and fuel cell power density and promoting widespread PEMFC *** recent years,atomically ordered Pt‐based intermetallic nanocrystals have received tremendous attention owing to their excellent activity and stability for the ***,in this review,we first introduce the formation of intermetallic compounds from the perspective of thermodynamics and kinetics to lay a theoretical foundation for the design of these *** addition,optimization strategies for Pt‐based ordered intermetallic catalysts are summarized in terms of the catalyst composition,size,and ***,we conclude with a discussion of the current challenges and future prospects of Pt‐based ordered *** review is designed to help readers gain insights into the recent developments in and rational design of Pt‐based intermetallic nanocrystals for the ORR and encourage research that will enable the commercialization of PEMFCs.

摘要：The partial 16 S r RNA gene sequences（100 to 500 bp） were widely used to reveal rumen bacterial composition influenced by diets, while quantification of the changed uncultured bacteria was inconvenient due to difficult designing of specific primers based on short sequences. This study evaluated the effect of forage resources on rumen bacterial diversity and developed new strategy for primer design based on short sequences to quantify the changed uncultured bacteria. Denaturing gradient gel electrophoresis（DGGE） analysis and subsequent band sequencing were used to reveal the distinct rumen bacteria composition in cows fed with two forage sources（single corn stover vs. mixed forages including alfalfa hay and corn silage）. The bacterial diversity in the rumen of dairy cows fed with corn stover was lower than that with mixed forages（P0.05）. The bacterium named R-UB affiliating to uncultured Succinivibrionaceae was identified, and it was abundant in the rumen of cows fed with mixed forages compared to corn stover. The full length 16 S r RNA gene sequences with identity of 97% to the R-UB 16 S r RNA gene sequence were obtained from Gen Bank and used to design specific primers to quantify uncultured bacterium R-UB. All sequences of amplicon from the new primers were of 100% identity to R-UB sequences indicating the high specificity of new primers. Quantitative PCR confirmed that abundance of R-UB in the rumen of cows fed with corn stover was lower than those fed with mixed forages（P0.01）. New strategy for designing primers based on partial 16 S r RNA genes to quantify targeted uncultured bacteria was successfully developed. The rumen bacteria descending significantly in the cows fed corn stover compared to those fed mixed forages was identified as uncultured R-UB from Succinivibrionaceae.

摘要：西南艰险山区分布有大量岩质边坡,长期冻融作用引起岩体力学性能发生劣化,进一步导致边坡稳定性降低。为研究岩体在冻融作用下的损伤劣化规律,选取某高陡边坡工程的低孔隙率石英岩进行不同冻融循环次数条件下的单轴压缩试验,分析其力学劣化和能量演化规律,并基于能量演化规律提出岩石完全压密点的确定方法,以完全压密点为分段点建立考虑压密段的岩石分段损伤本构模型。研究结果表明:前期冻融循环作用对石英岩的影响较小,当冻融循环次数>40时,石英岩的力学性能出现明显劣化,破坏模式由剪切破坏逐渐向拉-剪复合破坏转变;确定弹性能耗比K(耗散能/弹性应变能)为1.2对应的点为完全压密点,压密应变随冻融循环次数的增加呈线性增大;考虑压密段的岩石分段损伤本构模型与试验数据的匹配度较好,可更准确地描述冻融损伤石英岩的变形破坏特性。

摘要：针对正交编码信号已有设计方法计算复杂、编码长度和数量受限等问题,该文利用混沌序列类随机、初值敏感,易产生和易使用的特点,提出应用混沌序列设计随机离散频率编码信号。在给出编码信号设计方案的基础上,详细推导此类信号的模糊函数,分析了其距离、多普勒分辨能力,讨论了信号的准正交特性,并比较了不同混沌序列对信号性能的影响。理论分析和仿真实验表明,结合混沌序列的频率编码信号具有优良的模糊函数、准正交性能,且信号产生容易,编码长度和数量可以任意设置,可以作为一类有潜力的雷达信号使用。

摘要：To provide an accurate prediction of the product component dependence of temperature and pressure in vacuum distillation and give convenient and efficient guidance for the designing of the process parameters of industrial production, according to the molecular interaction volume model(MIVM), the separation coefficient(β) and vapor-liquid equilibrium composition of Au-Ag alloy at different temperatures are calculated. Combined with the vapor-liquid equilibrium(VLE) theory, the VLE phase diagrams, including the temperature-composition(T-x) and pressure-composition(p-x) diagrams of Au-Ag alloy in vacuum distillation are plotted. The triple points and condensation temperatures of gold and silver vapors are calculated as well. The results show that the β decreases and the contents of gold in vapor phase increase with the distillation temperature increasing. Low pressures have positive effect on the separation of Ag and Au. The difference between the condensation temperatures of gold and silver is about 450 K in the pressure range of 1-10 Pa.