摘要：广告是人类传达信息的重要手段。作为一种传达艺术,广告设计的本质在于一个有说服力的信息技巧的运用。想象中最活跃的心理活动是联想,言行中只有巧妙的构思,诱人的情趣,才能以情动人,使信息传达产生激动人心的力量。许多令人难忘的优秀的广告作品,正是从传达信息清晰、准确、可信、感人,给人以美的感受和联想以达到引人入胜的目的。

摘要：Carbohydrates, with broad-spectrum structures and biological functions, are key organic compounds in nature, along with nucleic acids and proteins. As part of our ongoing efforts to develop a new class of pesticides with novel mechanism of action, a series of novel N-glycosyl-l-pyridyl-lH-pyrazole-5-carboxamide was designed and synthesized via the reactions of glycosyl methanamides and pyridyl-pyrazole acid. The compounds were characte- rized by IH NMR and 13C NMR. The bioassay results indicate that some of these compounds exhibit moderate insec- ticidal activities and assessed as potential inhibitors of calcium channels. The modulation of voltage-gated calcium channels by compounds 4a and 5a in the central neurons isolated from the third instar larvae of Spodoptera exigua was studied by whole-cell patch-clamp technique. In addition, compound 5a inhibits the recorded calcium currents reversible on washout. Experimental results also indicate that compound 5a did not release stored calcium from the Endoplasmic Reticulum. The present work demonstrates that N-glycosyl-l-pyridyl-lH-pyrazole-5-carboxamides cannot be used as possible inhibitors of calcium channels for developing novel pesticides.

摘要：Deamination is a crucial step in the transformation of 6-cyclopropylamino guanosine prodrug to its active form. A convenient method using capillary electrophoresis （CE） without sample labeling was developed to analyze the deamination of a series of D-/L-6-cyclopropylamino guanosine analogs by mouse liver homogenate, mouse liver microsome, and adenosine deaminase （ADA）. A two-step process involving a 6-amino guanosine intermediate formed by oxidative N-dealkylation was demonstrated in the metabolism of 6-cyclopropylamino guanosine to 6-hydroxy guanosine. The results indicated that the transformation rates of different prodrugs to the active form varied greatly, which were closely correlated with the configuration of nucleosides and the structure of glycosyl groups. Most importantly, D-form analogs were metabolized much faster than their L-counterparts, thus clearly pointed out that compared to guanine, modification of glycosyl part might be a better choice for the development of L-Kuanosine analogs for the treatment of HIV,

摘要：胜任特征模型研究是人力资源管理理论和实践研究的前沿问题之一。目前对于创业者胜任特征研究逐渐增多,但是关于动漫行业创业者胜任特征模型的实证研究相对较少。本研究采用行为事件访谈方法,对31名动漫行业创业者进行访谈,初步确定了动漫行业创业者胜任特征为3个维度即个人品质、知识素质、能力素质,编码为12个特征即主动性、独立性、激情活力、抗挫折能力、公正公平、动漫知识、创意点子、经营及法律知识、沟通协调、团队建设、外部资源获取、持续创意。该特征模型对即将成为动漫行业的创业者和研究相关行业创业胜任特征的工作者提供了参考。

摘要：嘉德艺术中心是同时带有大悬臂和大跨转换层的复杂结构,为保证该结构的抗震安全性,进行了1:16的缩比振动台试验,并利用ABAQUS进行了弹塑性分析。研究了结构的动力特性,研究了结构在8度多遇、设防、罕遇地震及9度罕遇地震下的加速度响应、位移响应及损伤过程。并讨论了大悬臂桁架和大跨转换层桁架竖向地震作用计算方法。研究结果表明:该结构具有良好的变形能力和延性,具有足够的抗震储备能力,满足规范"小震不坏,中震可修,大震不倒"的设防要求;采用竖向振型分解反应谱法计算的竖向地震作用并不一定大于规范简化方法的结果,实际设计中宜取两者的包络;且对于8度抗震设防的大悬臂桁架和大跨转换层桁架,规范简化方法计算的竖向地震作用偏小,宜取重力荷载代表值的15%计算竖向地震作用。

摘要：提出了一种概念设计方案评估的模糊多准则决策方法,以降低决策者主观偏好以及评估过程中模糊和不确定因素对决策的影响。基于对影响产品竞争力因素的分析,建立了概念设计方案评价的层次结构。建立了概念设计方案评估的模糊多准则决策数学模型,并以三角模糊数代替常规层次分析法中的标度,提出了一种模糊层次分析方法来确定评价体系中各级评价准则的权重,充分考虑多领域专家的意见和产品开发过程的风险性。最后,以应用实例对提出模型的有效性和可行性进行了验证。

摘要：To accelerate the development and design of magnesium(Mg)alloys,the structural and mechanical properties of important precipitates in Mg−Zn alloys were studied by experiments and density functional *** nano-indentation tests revealed that the hardness of the precipitates initially increased and then decreased with increasing Zn content,and was significantly higher than that of pure Mg and *** calculation results revealed that the precipitates stability initially increased and then decreased with increasing Zn *** bulk moduli of the precipitates increased,whereas their shear and Young’s moduli initially increased and then decreased with increasing Zn *** decreasing order of ductility for these compounds is MgZn_(2)>Mg_(21)Zn_(25)>Mg_(2)Zn_(11)>Mg_(4)Zn_(7).The surface profiles of the compounds revealed that they are obvious *** the degree of covalency and bond length of covalent bonds initially increased and then decreased with increasing Zn content.

摘要：针对机械产品设计过程中,工程图纸、模型、标准规范等设计知识查询不便、重用率低的问题,提出了一种基于本体的机械产品设计知识嵌入方法。在此方法中,借助本体中的数据属性和对象属性,建立了以设计过程、设计组织、设计对象、知识对象四个设计要素为核心的本体模型,从而确保四者之间的紧密关联。根据自定义式知识嵌入和推送式知识嵌入的需求,提出了基于本体的知识嵌入机制,以满足设计过程中设计知识的动态变化和主动应用的要求。最后,以减速器为例建立了相应的设计本体,并开发了产品设计知识管理原型系统,验证了知识嵌入方法的实用性。

摘要：在固定和切换拓扑中通信网络含有加性随机噪声的情况下,针对随机多智能体系统一致性跟踪控制问题,本文采用自适应控制方法给出了一种新的一致性增益设计方法.在基于邻居智能体状态设计的分布式自适应控制协议中,每个跟随者的一致性增益自适应律仅仅依赖于跟踪误差,并且与通信网络全局信息无关.结合代数图论,随机理论工具和自适应控制得到两个结论:1)每个跟随者以均方意义下跟踪上领导者; 2)每个跟随者的一致性增益趋于一个理想估计值.通过两个仿真实例验证算法的有效性.

摘要：目的探讨好奇心在角色扮演类游戏设计过程中的具体表现以及指导意义。方法基于游戏好奇心理论,通过对国内外文献的研究及案例分析法,对玩家在游戏中的5种好奇心表现特征和角色扮演类游戏的设计过程进行分析,最终将得出的设计方法应用到网易游戏《镇魔曲》的夫妻活动界面设计中。结论归纳出好奇心理论在角色扮演类游戏设计过程中的关系模型图和基于好奇心理论的5种设计方法,即多通道的感官刺激、平衡性的游戏操作、可探索的游戏元素、目标导向型游戏设计和情感化的游戏体验。好奇心理论在游戏设计过程中的应用为游戏开发者提供了更多设计研究的思路,能促使开发人员设计出符合玩家心理需求且体验更好的游戏内容。