摘要：Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases. These compounds are represented by tenofovir (PMPA) a medicine for both HIV and HBV, and adefovir as an anti-HBV agent. More than this, other analogs, such as GS9148, GS9131, and GS7340, are also wellknown anti-viral agents that have been progressed to the clinical studies for their excellent activity. in general, the structures of these compounds include an adenine nueleobase linked to a phosphonate side ehain. Considerable structural modifications on the scaffold itself and the peripheral sections were made. The structure-activity relationships (SARs) of this skeleton will provide valuable clues to identify more effective adenine derivatives as antiviral drugs. Here, we systematically summarized the SARs of the adenine derivatives, and gave important information for further optimizing this template. (c) 2015 Chinese Pharmaceutical Association and Institute of Materia Medial., Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

摘要：基于被动行走原理,建立了被动两杆行走模型,推导了系统动力学方程并进行了数值求解。在此基础上,设计了4种能量转化模块及被动助力关节。结合人体工程学,设计了无动力外骨骼结构并进行了运动学仿真。利用理论研究成果,加工了原理样机,进行了相关测试及实验。

摘要：利用平面多闭环连杆机构,提出一种可变形机翼结构,并对该结构进行数学建模,利用结构数学模型,在Matlab中进行了机构的运动轨迹仿真分析。为了验证机构曲率调节能力及气动特性,建立了机构的三维模型,进行了运动学仿真及空气动力学仿真分析。为了获得更好的气动特性,基于传统人工鱼群优化算法,提出一种改进的人工鱼群优化算法,利用经典优化算法测试函数测试了该算法的性能。采用该优化算法对可变形机翼进行结构优化。在理论研究的基础上,加工了实验样机,并进行了相关实验测试。

摘要：随着我国老龄化社会趋势日益加重,半失能老人将成为一个十分庞大的群体,给养老机构及护理机构带来巨大压力。半失能老人绝大多数患有下肢运动功能障碍,无法独立行走。针对半失能老人这一群体,提出了行走辅助轮椅结构设计方案,并对关键部件进行了力学仿真及人机耦合情况下的运动学仿真,搭建了行走辅助轮椅系统框架。为验证理论设计的正确性,加工了行走辅助轮椅实验样机,并完成了相关实验。研究结果为设计行走辅助轮椅提供了理论基础。

摘要：为有效解决下肢肌肉功能退化及中风偏瘫等疾病导致的老年人下肢运动功能障碍,从康复医学的角度,分析了康复运动对下肢功能障碍患者恢复的重要性,结合人体生理结构,建立了人体肌骨模型,进行了肌骨仿真分析。为了准确判断患者的运动意图,设计了3种外骨骼专用传感器。在此基础上,提出了力感知助力关节结构方案,并设计了下肢动力外骨骼整体结构,进行了人机耦合运动学仿真分析。在结构设计的基础上,设计了下肢外骨骼的硬件及电气系统。为了验证理论研究的正确性,加工了外骨骼实验样机,进行了相关实验。实验结果说明,设计的外骨骼专用传感器可以准确获取相应信号,助力关节可以提供较大的关节助力,设计的下肢动力外骨骼能够准确判断患者的运动意图,可以长时间稳定安全地进行平地行走及斜坡行走。

摘要：深埋长大硬岩隧道多利用隧道掘进机(TBM)施工,但在掘进过程中存在因遭遇不良地质发生卡机的风险。目前,用于TBM施工隧道的超前地质预报方法较少,准确预报不良地质成为对TBM施工隧道超前地质预报技术的重要考验。以大瑞铁路高黎贡山隧道开敞式TBM施工综合超前地质预报技术应用为例,提出一种地表与隧道内相结合的综合超前地质预报方法,以区域地质条件为基础,结合地勘资料、预报资料,得出综合超前地质预报结论。在此基础上,参考TBM掘进参数,综合研判卡机风险等级。应用该方法可提高TBM施工超前地质预报的准确度,降低TBM卡机风险,保障隧道安全顺利掘进。

摘要：基于半失能老人步态特征,建立了人体下肢运动学模型,推导了人体行走动力学方程,在此基础上,设计了面向半失能老人的无动力下肢外骨骼结构。为了便于用户穿戴,基于人体工程学,完成了外骨骼绑带等柔性部件结构的设计及外观设计。为验证文中设计的外骨骼性能及可靠性,加工了无动力下肢外骨骼样机,并进行了相关测试及实验。

摘要：提出了基于注意力机制的多模态人体行为识别算法;针对多模态特征的有效融合问题,设计基于注意力机制的双流特征融合卷积网络(TAM3DNet,two-stream attention mechanism 3D network);主干网络采用结合注意力机制的注意力3D网络(AM3DNet,attention mechanism 3D network),将特征图与注意力图进行加权后得到加权行为特征,从而使网络聚焦于肢体运动区域的特征,减弱背景和肢体静止区域的影响;将RGB-D数据的颜色和深度两种模态数据分别作为双流网络的输入,从两条分支网络得到彩色和深度行为特征,然后将融合特征进行分类得到人体行为识别结果。

摘要：Efficient catalysts enable MgH2 with superior hydrogen storage ***,we successfully synthesized a catalyst composed of Ce and Ni (***_(5) alloy) with splendid catalytic action for boosting the hydrogen storage property of magnesium hydride (MgH_(2))The MgH2–5wt%CeNi_(5) composite’s initial hydrogen release temperature was reduced to 174℃ and approximately 6.4wt%H_(2) was released at 275℃ within 10 ***,the dehydrogenation enthalpy of MgH_(2) was slightly decreased by adding CeNi_(5).For hydrogenation,the fully dehydrogenated sample absorbed 4.8wt%H_(2) at a low temperature of 175℃.The hydrogenation apparent activation energy was decreased from(73.60±1.79) to (46.12±7.33) kJ/*** analysis revealed that Mg_(2)Ni/Mg_(2)NiH_(4) and CeH_(2.73) were formed during the process of hydrogen absorption and desorption,exerted combined“Gateway”and“Spillover”effects to reduce the operating temperature and improve the hydrogen storage kinetics of MgH_(2).Our work provides an example of merging“Gateway”and“Spillover”effects in one catalyst and may shed light on designing novel highly-effective catalysts for MgH_(2) in near future.

摘要：On the basis of the microstructure of the cross-section of a beetle's elytra,three bio-inspired lightweight structures were designed and built from acrylonitrile butadiene styrene plastic with a three-dimensional *** mechanical properties of three lightweight structures were analyzed and compared employing the finite element method,and quasi-static compression experiments and a three-point bending test on the structure samples were carried out using an electronic universal testing machine to verify the effectiveness of the finite element *** results show that all three bio-structures were lightweight and had excellent mechanical *** particular,the bio-structure with spherical holes and hollow columns perpendicular to the top and bottom surfaces best imitated the microstructure of the cross-section of the Cybister elytra and had the greatest specific strength/stiffness in compression and ***,a preliminary optimization design was obtained for this bio-structure to further improve its specific strength and specific stiffness to 31.82 kN m/kg and 108.73 kN m 2 /kg respectively.