摘要：The growth plate(GP)is a crucial tissue involved in skeleton development via endochondral ossification(EO).The bone organoid is a potential research model capable of simulating the physiological function,spatial structure,and intercellular communication of native ***,mimicking the EO process remains a key challenge for bone organoid *** simulate this orderly mineralization process,we designed an in vitro sh Ca_(v)3.3 ATDC5-loaded gelatin methacryloyl(Gel MA)hydrogel model and evaluated its bioprintability for future organoid *** this paper,we report the first demonstration that the T-type voltage-dependent calcium channel(T-VDCC)subtype Ca_(v)3.3 is dominantly expressed in chondrocytes and is negatively correlated with the hypertrophic differentiation of chondrocytes during the EO ***,Ca_(v)3.3 knockdown chondrocytes loaded with the Gel MA hydrogel successfully captured the EO process and provide a bioink capable of constructing layered and orderly mineralized GP organoids in the *** results of this study could therefore provide a potential target for regulating the EO process and a novel strategy for simulating it in bone organoids.

摘要：A novel extrusion-shearing(ES) composite process was designed to fabricate fine-grained, high strength and tough magnesium alloy. The structural parameters of an ES die were optimized by conducting an orthogonal simulation experiment using finite element software Deform-3D, and Mg-3 Zn-0.6 Ca-0.6 Zr(ZXK310) alloy was processed using the ES die. The results show that the optimized structural parameters of ES die are extrusion angle(α) of 90°, extrusion section height(h) of 15 mm and inner fillet radius(r) of 10 mm. After ES at an extrusion temperature and a die temperature of 350 °C, ZXK310 alloy exhibited good ES forming ability, and obvious dynamic recrystallization occurred in the forming area. The grain size decreased from 1.42 μm of extrusion area to 0.85 μm of the forming area. Owing to the pinning of second phase and formation of ultrafine grains, the tensile strength, yield strength and elongation of alloy reached 362 MPa, 289 MPa and 21.7%, respectively.

摘要：AM50-4%(Zn,Y)alloy with a Zn/Y mole ratio of6:1was subjected to thermal analysis,and the results were used for designing a two-step progressive solution treatment *** effects of solution and aging treatments on the microstructure and mechanical properties of the AM50-4%(Zn,Y)alloy were investigated using OM,XRD,SEM/EDS,TEM,tensile test and hardness *** experimental results demonstrated that the two-step progressive solution treatment could make theΦandβphases sufficiently dissolve into the matrix which possessed higher supersaturated degree of the dissolved solute compared with the one-step solution *** resulted in a certain enhancement of the precipitation strengthening effect during the subsequent aging *** precipitation of theФphase had a greater impact on the comprehensive mechanical properties of the alloy thanβphase precipitation when the aging treatment was performed at180℃.The peak aging strength of the AM50-4%(Zn,Y)alloy which was subjected to the two-step progressive solution treatment process(345℃for16h and375℃for6h)was obtained after the aging treatment at180℃for12h.

摘要：目的 探索开发者工具链体验设计策略,以解决我国数字化转型背景下开发者工具链缺乏系统设计规范、业务准入门槛高、自主研发能力不足等问题。方法 采用数据分析法、用户访谈法和案例研究法等,归纳与分析数字化转型的特征要素和系统框架,挖掘开发者业务诉求,构建用户画像与开发者旅程,并解析案例产品的体验要素,归纳其设计规律。结果 构建出“质量-效率-体验”背景支撑下的系统框架,总结出开发者工具链的特点及发展路径,提出整合式、中台化、模块化的体验设计策略。结论 开发者工具链作为数字化转型的“新基建”,发展潜能巨大,构建数字化转型背景下的开发者工具链体验设计策略,有助于推动设计与开发全域融通,降低工具链设计的业务壁垒,提高数字化产品开发效率,助力企业实现高质量数字化转型。

摘要：以京台高速公路某大桥为工程背景,设计了相应的新型组合高墩。通过有限元方法,考虑包括材料与几何非线性,分别采用实体单元建立了针对高墩悬臂施工阶段的模型,以及梁单元建立了全桥运营阶段模型分析其稳定性,获得其稳定承载力以及稳定系数。通过有限元参数分析,探讨了不同工况、墩身高度、软钢板厚度、屈服强度以及系梁间距对高墩稳定性的影响。计算结果表明,悬臂不平衡施工为最不利工况,组合高墩发生纵桥向压弯变形失稳,该阶段高墩的稳定系数相较悬臂平衡施工阶段下降30%。不同工况下,墩身的最不利截面处于受压侧钢管混凝土柱距离墩底0.1~0.2高度区域;随着墩身长细比增大,稳定系数出现显著下降,其破坏模式由弹塑性失稳逐渐转变为弹性失稳;软钢板厚度增大有利于稳定系数的提高;系梁间距按照传统高墩经验设计,取10 m~12 m最有利高墩稳定。基于参数分析结果,提出新型组合高墩简化模型,所得到的稳定承载力计算方法,适用于长细比超过70的组合高墩;当长细比小于70,建议采用短柱极限承载力折减方法计算。

摘要：目的优化脊痛宁片醇沉工艺。方法采用质量源于设计(QbD)理念,在单因素试验基础上,以浓缩液密度、目标醇度、搅拌时间为影响因素,葛根素、芍药苷、甘草酸保留率及总固体、总糖去除率为评价指标,Plackett-Burman设计、Box-Behnken响应面法结合Monte-Carlo算法建立设计空间,优化醇沉工艺。结果最优设计空间为浓缩液密度1.11~1.13 g/mL,目标醇度71%~73%,搅拌时间30~34 min。结论QbD理念可更好地理解和控制脊痛宁片醇沉工艺,确保该制剂生产过程质量稳定。

摘要：The high phase content of inorganic dielectric fillings will give a strong electric driving force and hard matrix. That is a contradiction in enhancing the electrodeformation of dielectric elastomers(DEs). Therefore, in this paper, by focusing on how to approach a balance between these and finding an effective way to tune the electric response of the DEs, the theoretical calculation and experimental investigation based on calcium copper titanate(CCTO)/poly(dimethyl siloxane)(PDMS) were carried out. It is found that CCTO with a smaller particle size shows a larger dielectric parameter. With smaller CCTO particle as the fillings, the fabricated elastomer composite would approach to a low modulus by a proper CCTO phase morphology in the matrix.

摘要：针对单相充电系统输出侧存在的二次功率脉动问题,提出1种低电压纹波单相电驱重构型车载充电机EDROC(electric drive reconstructed onboard charger)系统。该系统通过在传统单相EDROC系统输出侧并联1个Buck/Boost型有源滤波器,用于吸收或补偿二次功率脉动,显著降低了充电系统的输出电压纹波。首先,分析单相EDROC系统的拓扑结构、工作原理和输出侧二次功率脉动产生机理;然后,结合Buck/Boost型有源滤波器,提出1种低电压纹波单相EDROC系统,并对Buck/Boost型有源滤波器拓扑结构、工作原理以及电感和电容选型进行了详细分析;接着,对所提EDROC系统控制策略进行设计;最后,设计了1台200 W实验样机,实验结果验证了所提充电机的可行性。

摘要：针对当前热态H型钢断面全尺寸测量需求,设计了一种基于线结构光的热态H型钢断面尺寸测量系统。测量系统由4个线结构光子系统、H型钢、电机等组成,通过各侧相机对H型钢进行图像采集,并将测量数据拼接实现热态H型钢断面全尺寸测量。为实现热态H型钢断面轮廓信息的精确提取,提出一种基于法线的高斯滤波线结构光中心线提取方法,分析高斯滤波对线结构光截面灰度分布对称均匀程度的影响规律,利用几何矩构建高斯截面灰度分布模型;在构建的模型基础上,设计一种基于法线的线结构光中心线提取方法,根据初提取中心线法线方向进行中心坐标计算和插值优化,实现热态H型钢线结构光图像中心线快速高精度提取。设计一种基于特征点检测的热态H型钢断面尺寸测量算法,分析热态H型钢轮廓形状特点和数学特征,拾取尺寸特征点,实现热态H型钢断面全尺寸测量。结果表明,与考虑膨胀系数后的热态H型钢尺寸相比,高度、宽度和翼缘的最大相对误差分别为0.06%、1.8%和1.76%;腹板厚度最大绝对误差为0.23 mm。提出的测量算法满足测量需求,能够实现热态H型钢断面尺寸测量。

摘要：石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、硼-硼(B-B)掺杂、铍(Be)掺杂和铍-铍(Be-Be)掺杂均会导致单层石墨烯纳米梁的振动频率降低.此外,随着硼(B)/铍(Be)掺杂浓度的增加,单层石墨烯纳米梁的振动频率逐渐降低.且随着掺杂浓度的增加,硼(B)掺杂石墨烯纳米梁的振动频率和铍(Be)掺杂石墨烯纳米梁的振动频率的差异逐渐增大.这对石墨烯纳米机械谐振器、振荡器等纳米器件的设计具有一定的理论指导意义.