摘要：Novel histone deacetylase （HDAC） inhibitors 9a-1 were designed and synthesized by coupling the carboxyl group of salicylic acid （SA） with N-hydroxycinnamamides through various alkylol amines, and their in vitro biological activities were evaluated. The N-hydroxycinnamamide/SA hybrids 9b-f and 9h showed good to moderate anti-tumor activities. Notably, compound 9e had a greater potency, comparable to vorinostat （SAHA）, in human colon carcinoma cells, which was probably, or at least partially, attributable to the positive effects of the chain length noted in allojlol amines. Furthermore, the HDAC inhibitory activities of 9e against Hela cell nuclear were also similar to that of vorinostat （SAHA）, while the tested compounds 9c-f did not exhibit any isoform selectivity in the inhibition of HDACs. In addition, compound 9e could selectively inhibit tumor cells, but not inhibit non-tumor cell proliferation in vitro. Our findings suggest that the N-hydroxycinnamamide/SA hybrids may hold significant promise as therapeutic a^ents for the intervention of human cancers.

摘要：影响磁耦合谐振式无线电能传输系统的传输功率和传输效率的主要因素有输入电压、工作频率、发射侧和接收侧线圈之间的互感、交流内阻以及负载阻抗等。因此系统的优化设计是一个多参数多约束的问题。由于各参数之间相互影响且利用现有解析法计算圆导线螺旋线圈的交流内阻不仅复杂还存在一定的误差,所以本文基于遗传算法利用Matlab和Ansoft进行联合仿真来综合考虑各影响因素,以系统的传输效率为优化目标,同时对传输功率和空间位置进行约束,得到最终的一组优化参数。最后,本文将所得的优化参数带入saber进行电路仿真,仿真结果与优化结果具有较好的一致性。这为设计磁耦合谐振式无线电能传输系统时选择合适的参数提供了一种优化方法。

摘要：This article firstly proposes two problems related to geological structure inversion with acoustic computed tomography (CT): ① the results surveyed are different from true stratum layers; ② the existing acoustic CT inversion methods are based on wave's travel route and velocity analysis, which is short of comprehensive analysis of the revealed geological data. Then, it puts forward the method of applying the borehole data to revise acoustic CT investigation result through controlling the boundary velocity. This method comprehensively uses acoustic data and borehole data to invert the rock masses' shear wave speed. Comparing to calculating the rock mass' wave speed with acoustic data alone, it makes full use of the information, and the results obtained are closer to real stratum. Finally, it applies the method to engineering project and the results gotten with the method are more accurate, which shows the reliability and accuracy of the method.

摘要：目的探究几种典型的设计驱动型品牌的创新范式,为国内不同类型的企业转向设计驱动型品牌提供创新范式参考。方法借助设计驱动式创新理论确定设计驱动型品牌的特征,并以此为根据判断研究对象设计驱动型品牌,再从创意来源、创意实现过程和创新成果3个方面分析不同的设计创新驱动式创新范式。结论以鸿翼科技为代表的设计探索式创新,其创意来源于内部团队挖掘痛点,以优化产品和解决市场痛点为创新逻辑,其创意效果根据企业的创新策略而实现,其成果以硬件产品为主。以小米公司为代表的设计开放式创新,其创意来源于线上用户社群和生态链创新团队,且创意过程由研发工程师在线获取反馈信息而实现,最终创新成果主要表现为硬件产品、系统和服务。以苹果公司为代表的设计整合式创新,其创意来源于虚拟社群和技术整合,且创意过程由内部团队根据企业目标而实现,最终创新结果主要有硬件产品、软件、系统、技术和服务。

摘要：For the carbon-neutral,a multi-carrier renewable energy system(MRES),driven by the wind,solar and geothermal,was considered as an effective solution to mitigate CO2emissions and reduce energy usage in the building sector.A proper sizing method was essential for achieving the desired 100%renewable energy system of *** paper presented a bi-objective optimization formulation for sizing the MRES using a constrained genetic algorithm(GA)coupled with the loss of power supply probability(LPSP)method to achieve the minimal cost of the system and the reliability of the system to the load real time *** optimization App has been developed in MATLAB environment to offer a user-friendly interface and output the optimized design parameters when given the load demand.A case study of a swimming pool building was used to demonstrate the process of the proposed design *** to the conventional distributed energy system,the MRES is feasible with a lower annual total cost(ATC).Additionally,the ATC decreases as the power supply reliability of the renewable system *** is a decrease of 24%of the annual total cost when the power supply probability is equal to 8%compared to the baseline case with 0%power supply probability.

摘要：目的提升船舶设计艺术水平和创新能力。方法基于设计艺术学与船舶工程设计的相关理论,综合运用系统归纳与设计分析方法,归纳船舶设计艺术理论与方法的主要内容,探讨船舶设计艺术创新的性质、方法、实现模式并构建体系模型。结论初步构建了船舶设计艺术的理论体系。

摘要：锂电池更好的循环性能和安全性能是电动汽车获得更广泛市场优势的迫切需要,深入了解电解液退浸润的形成机理是长寿命电池发展的关键。该文采用一种超声无损检测方法,从两个维度对市面上常用的3种包装类型的锂离子电池在使用过程中内部电解液发生的变化进行了研究。结果发现:在长度方向,极耳附近相比其他位置更容易出现电解液退浸润的情况,且正极比负极更容易出现退浸润缺陷;厚度方向上电池中间层比外层区域更容易出现退浸润现象。分析发现,这主要是由于电池材料选取与结构设计导致极耳位置具有更高的电流密度和温度,电解液发生反应消耗,加快了此区域的老化进程。最后针对这一现象对未来电池选材与设计和锂电池的发展给出了建议。

摘要：职业体育的生产者包括俱乐部和联盟,消费者包括观众、广告赞助、媒体和地方政府。其主要的市场特征包括三点,即带有自然垄断性质的联盟、相互竞争与合作的俱乐部和深入参与生产的各种类型消费者。这三个特点决定了职业体育特殊的组织形态和制度安排。

摘要：无尾式飞行器是飞行器发展的方向,研究无尾式控制具有重要意义。研究了线性变参数系统的增益调度控制器的设计方法,采用多胞形进行增益调度,提出了一种简单实用的变参数顶点凸分解方法,该方法在保证系统稳定的情况下,确保系统达到最优性能指标。同时还充分考虑了系统的不确定性因素,利用线性矩阵不等式(LMI)对系统进行鲁棒控制器设计,大大减少了计算量以及对系统的约束,设计出了基于LMI的增益调度控制器,通过非线性仿真结果可以看出,该控制器在调节变量变化很大的情况下,使得系统在0.5s内收敛,而且超调量很小,论证了该方法在无尾式飞控系统中应用的可行性。

摘要：针对双足机器人步行控制器的设计问题,基于生物学启发原理,提出一种基于中枢模式发生器(CPG)与稳定性分析相结合的多层次结构控制器设计方法.分析机器人的步行运动,给出双足运动描述.基于CPG理论设计多层次结构的步行控制器,应用极限环理论方法分析运动稳定性.在保证步行稳定的前提下,所提出的控制方法具有结构简单、通用性好、方便在线平滑修正等优点,步行仿真实验验证了所提出算法的有效性.