摘要：In this review, we retrospect our progress in biological active naphthalimide and analogues as antitumor agents in the past 20 years. On one hand, various derivations in naphthalimide pharmacophores were developed to enhance their DNA binding affinity and antitumor property thereby. Heterocyclic fused naphthalimides, bis-naphthalimides, non-fused substituted naphthalimides and the carboxamide derivatives were synthesized. For example, thio-heterocyclic fused-naphthalimides were designed and evaluated in comparison with their oxo-heterocyclic fused analogues. Extended or created heterocyclebased skeleton were also developed as antitumor agents. On the other hand, we broaden the design strategy of naphthalimide antitumor agents besides DNA intercalation and topo II poison. We have introduced more drug design methods, such as prodrugs, multitarget drugs, computer-aided drug design,photodynamic therapy. For example, we have got naphthalimide derivatives which inhibited topo II and induced LMP by introducing long alkyl chain and polyamines. Several representative compounds were clarified of their antitumor mechanism of action. In all, our research improves the structure diversity of naphthalimide antitumor agents and distinct variances of antitumor targets and mechanism of action.

摘要：Current states of traumatic eye injury are reviewed in terms of epidemiology in the developing countries and developed countries, causes of the trauma, eye injury types, traumatic eye injury diagnostic methods and treatments. Trauma-caused vision-threatening conditions such as open global injury, traumatic optic neuropathy and proliferative vitreoretinopathy are particularly discussed. Also the most updated clinic research in China as Eye Injury Vitrectomy Study is discussed. At the end, the current achievements and research in traumatic eye injury in the world are summerized.

摘要：A validated numerical model was established to simulate gas−liquid flow behaviors in the oxygen-enriched side-blown bath *** model included the slip velocity between phases and the gas thermal expansion *** modeling results were verified with theoretical correlations and experiments,and the nozzle-eroded states in practice were also involved in the *** comparison,it is confirmed that the thermal expansion effect influences the flow pattern significantly,which may lead to the backward motion of airflow and create a potential risk to production ***,the influences of air injection velocity and furnace width on airflow behavior were investigated to provide operating and design *** is found that the thin layer melt,which avoids high-rate oxygen airflow eroding nozzles,shrinks as the injection velocity increases,but safety can be guaranteed when the velocity ranges from 175 to 275 m/***,the isoline patterns and heights of thin layers change slightly when the furnace width increases from 2.2 to 2.8 m,indicating that the furnace width shows a limited influence on production safety.

摘要：hotodynamic therapy(PDT)has been drawing more and more attention in the antibacterial *** photosensitizers(PSs)tend to aggregate in aqueous media,which reduces the generation of reactive oxygen species(ROS)and seriously affects the photodynamic *** efforts have been made to prevent aggregation of traditional *** contrast,aggregation-induced emission PSs(AIE-PSs)take advantage of aggregation to boost ROS generation and fluorescence ***,the efficacies of the reported antibacterial AIE-PSs are ***,we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid ***,a negatively charged AIE-PS,can not only selectively kill spherical bacteria(Staphylococcus aureus(***))rather than rod-shaped bacteria(Escherichia coli(***)),but also be easily extended to several AIE-PSs(TTVBP1–3)with positive charges and broad-spectrum antibacterial *** demonstrate that TTVBP2 can kill3.0 log_(10)of *** at very low concentration(125 nmol L^(-1)),TTVBP3 can kill 4.7 log_(10)of Staphylococcus epidermidis(***)at a concentration of 1μmol L^(-1)and 3.8 log_(10)of *** at 5μmol L^(-1),thus enabling them among the most effective antibacterial AIE-PSs reported so ***,these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with *** thus envision that TTVBA,a nitrobenzoic acid-based extendable AIE-PS,provides a new route for the design of AIE-PSs in antibacterial treatment.

摘要：Lead halide perovskite nanocrystals(NCs)exhibit high photoluminescence quantum yield(PLQY),high defect tolerance,narrow half peak width,and wide luminous gamut,making them the ideal optoelectronic materials in numerous ***,their production still suffers from the limited productivity at the bench *** this work,we fabricated CsPbX3(X=Cl,Br,I)NCs within droplet-based micro-reactors,where both the nucleation and growth processes could be precisely controlled inside 130-nL *** provides a new paradigm for the large-scale synthesis of perovskite NCs with high *** with other synthetic methods,this method can increase the concentration of reactant precursors by 3±116 times,while lowering the ligand to reactant ratio to 2%±50%of the commonly used hot-injection *** modulating the reaction temperature and residence time,the structure-function relationship between the morphology of NCs and PL properties was extensively *** microfluidic-based process allows the flexible adjustment in the proportion of PbX2 precursors to achieve the fabrication of perovskite NCs whose luminescence range covers the entire visible spectrum(406±677 nm)within one ***,perovskite NCs with different halide ions were encapsulated in polymethyl methacrylate to prepare a colored light-emitting diode strip.

摘要：研究旨在探索基于STEM教育理念的运动生物力学课程的新型教学模式,评估其对学生学习效果提升的独特优势与内在机制。文章在分析课程特征的基础上,构建关键学习节点进阶式的运动生物力学课程教学模式,并通过系统动力学仿真分析,探索影响学习效果的关键因素。研究发现,该教学模式能够提升学生课程学习的关键能力,有效促进学生对课程知识内容的系统掌握。个体情绪状态、课程学习成绩、个体学习能力、课程满意程度共同构成了学习效果提升的系统过程,呈现出稳步上升—停滞不前—显著提升的演进特征。建议教师应深刻理解有效性学习发生的关键节点,有针对性地设计课程教学活动,避免学生出现课程知识学习的疲惫期。同时,注重新旧知识的有机融合与合理衔接,促进课堂知识的有效迁移,以提升教学效果。

摘要：Taking an oxygen enriched side-blown furnace as the prototype,a hydraulic model was established according to the similarity *** influence of three factors on the gas-liquid two-phase flow was analyzed,*** airflow speed,the submerged depth and the downward angle of the nozzle.A numerical simulation of the hydraulic model was carried out trying to find the suitable turbulence model which can describe the side-blown two-phase flow correctly by comparing the simulation results with the experimental *** experiment shows that the airflow speed has a great influence on the flow of the *** submerged depth of the nozzle has a relatively smaller influence on the penetration depth and the surface fluctuation height in the liquid *** the nozzle is at a downward angle of 15°,the penetration depth and the surface fluctuation height are *** is concluded that the numerical results with the realizable k-εturbulence model are the closest to the experiment for the penetration depth,the surface fluctuation height and the bubble scale.

摘要：With urbanization accelerating, people’s living standard is growing and their demands on lifestyle are improving accordingly. The research proposed housing gardening system based on low-carbon greenhouse technology from perspectives of air quality, food safety and environment-friendliness. Besides, the research detailed designs of planting system, water circulation system and lighting system by interpretation on low-carbon greenhouse technology, microclimate and housing gardening system.

摘要：为了准确反映风电场群无功策略的控制性能,加速对风电场群自动电压控制(AVC)策略的验证,搭建了风电场群模型。根据风电场间输电线路距离对模型进行分割,并建立各子风电场模型之间、子风电场与AVC硬件之间的通信,监测各控制节点实时电压。最后,基于由UREP300实时仿真器搭建的风电场群AVC硬件在环(HIL)试验平台验证了风电场群AVC策略的可行性。

摘要：随着市场经济的不断发展和完善,广告成为文学艺术作品走向市场、走向大众的主要媒介;文学艺术为广告创作提供了丰富的素材,广告作品更加广泛地表现多种文学艺术门类、文学艺术形式。广告为文学艺术的传承发挥着日益积极的促进作用。