摘要：The Accelerator Driven Sub-critical(ADS)system is a strategic plan to solve the nuclear waste problem for nuclear power plants in ***-energy particle accelerators and colliders contain long strings of superconducting devices,superconducting radio frequency cavities,and magnets,which may require cooling by 2 K superfluid helium(HeliumⅡ).2 K superfluid helium cryogenic system has become a research hot spot in the field of superconducting *** this study,the ADS Injector-I 2 K cryogenic system is examined in *** cryogenic system scheme design,key equipment,and technology design,such as the 2 K Joule–Thomson(J–T)heat exchanger and cryomodules CM1+CM2 design,are examined,in addition to the commissioning and operation of the cryogenic *** ADS Injector-I 2 K cryogenic system is the first 100 W superfluid helium system designed and built independently in *** ADS proton beam reached 10 Me V at 10 m A in July 2016 and 10 Me V at 2 m A in continuous mode in January 2017 and has been operated reliably for over 15,000 h,proving that the design of ADS Injector-I 2 K cryogenic system,the key equipment,and technology research are reasonable,reliable,and meet the *** research into key technologies provides valuable engineering experience that can be helpful for future projects such as CI-ADS(China Initiative Accelerator-Driven System),SHINE(Shanghai High Repetition Rate XFEL and Extreme Light Facility),PAPS(Platform of Advanced Photon Source Technology),and CEPC(Circular Electron-Positron Collider),thereby developing national expertise in the field of superfluid helium cryogenic systems.

摘要：Fast charge transfer and anti-photocorrosion are two crucial factors for developing efficient, durable photoanodes for photoelectrochemical （PEC） cells. Reduced graphene oxide （RGO） is a promising photoanode element that can provide both of these. In this study, we elucidated the roles of RGO in the charge transfer and surface passivation of photoanodes by the precise design of a RGO-wrapped photoanode and examination of its PEC properties. Arrays of hetero-nanorods （HNRs） with three different designs were fabricated as photoanodes using RGO, CdSe nanoparticles （NPs）, and ZnO nanorods （NRs） as building blocks. CdSe@ZnO HNRs were prepared by decorating ZnO NRs with CdSe NPs. Finite-element analysis and experimental studies demonstrated that in the CdSe@ZnO HNRs, if only the ZnO NRs were wrapped by RGO, the conductivity between CdSe and ZnO was enhanced by RGO to shuttle charges. If RGO only surrounded the outside of the CdSe@ZnO HNRs, the corrosion was slowed owing to the passivation effect of RGO, which increased the electron lifetime of the photoanode. If both CdSe and ZnO were fully wrapped by RGO, the advantages of the two aforementioned cases were both obtained. RGO-wrapped CdSe@ZnO HNRs with position-controlled designs are promising photoanode materials with a high PEC efficiency, and the developed synthesis process can be applied to explore the design and fabrication of next-generation photoanodes using RGO as a buildin~ block.

摘要：A series of pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione derivatives was designed and synthesized,and their neuroprotective activity against SH-SY5Y cell injury induced by N-methyl-D-aspartic acid(NMDA)was *** the compounds showed significant neuroprotective effects,especially B16,which showed excellent performance and better activity than the positive control ifenprodil(B16:56.2%±0.6%;ifenprodil:41.0%±2.7%).Further investigation indicated that B16 could attenuate the Ca^(2+)influx induced by NMDA in SH-SY5Y cells and Western blotting also showed that B16 could attenuate the NR2B upregulation in SH-SY5Y cells induced by *** molecular docking results showed that compound B16 fitted in the binding pocket of NR2B-NMDAR well and could interact with binding sites of compounds 1 and 2 *** ADME/Tox prediction results suggested that compound B16 had good blood-brain barrier(BBB)permeability and the zero alert of Pan Assay Interference Structures(PAINS)indicated that B16 could not elicit false-positive *** results strongly suggest that B16 is a promising and effective candidate neuroprotective compound,and that NR2B-NMDAR is a potential target of B16.

摘要：作为审计工作的落脚点和价值核心,审计整改在政策层面、理论研究和实务操作中缺乏系统、有效的机制,导致审计发现问题“怎么改”缺乏科学理论及最佳实践。研究设计有效、可行的审计整改机制,对于发挥审计工作价值尤为必要。文章基于价值链理论,参照质量管理领域双五归零方法,构建审计整改6R机制;并基于中国商飞的审计整改实务数据,对机制的有效性进行验证。研究表明,审计整改6R机制能够为企业创造价值,六个关键要素相互作用、缺一不可;且单个关键要素价值趋势呈现“两端高、中间低”的形态规律,符合微笑曲线趋势。文章从定量视角对审计整改要素进行考察,拓展了审计整改方法,丰富了审计整改理论。

摘要：A mesoporous silica/gold （MSN/Au） nanocomposite was designed for photo- controlled drug delivery targeted specifically at tumor cells. The MSN/Au nanocomposite was composed of MSN-based drug carriers and gold nanoparticle （AuNP）-based indicators. While the MSN-based drug carrier was a mesoporous silica nanoparticle immobilized with photo-switchable azobenzene （Azo） moieties, the AuNP-based indicator was a fluorescence-quenched AuNP modified with a matrix metalloproteinase （MMP） substrate and poly（ethylene glycol）. The two kinds of nanoparticles were connected by an α,β cyclodextrin （α,β CD） dimer ＂bridge.＂ In vitro studies demonstrated that the nanocomposite specifically interacted with tumor sites overexpressing MMP-2, which enabled guidance of the subsequent UV light irradiation for releasing entrapped drugs. Through integration of the AuNP-based indicator and the MSN-based drug carrier, the MSN/Au nanocomposite could precisely localize the released drug to tumor sites, thereby significantly improving therapeutic efficacy.

摘要：动漫IP形象开发以其受众年轻化、传播渠道丰富、衍生能力强等优势,推动了传统文化的传承和发展。目前,我国现有牡丹动漫IP形象普遍存在定位模糊、角色形象严重同质化等问题。为促进牡丹文化传播,进而为讲好“黄河故事”提供可参考的思路,应通过文化主题、形象定位、形象识别等方面的创新,设计新的“牡丹传说”动漫IP形象。

摘要：《艺术市场研究》在准确把握艺术市场现状的基础上,鲜明地提出现实问题,精心梳理历史问题,开阔了研究思路,不失为引导艺术市场运营消费的学术参照;另一方面,它为我国艺术市场专业建设和人才培养提出了启示性的发展思路。

摘要：打谱是将一首古琴曲的曲谱与音响近乎原貌的展现,其中包括将曲谱(减字谱、简谱或五线谱)、注释、打谱过程甚至由此得到的心得体会提升至具有学术价值的研究性报告。琴歌《阳关三叠》最早见于明代《渐音释字琴谱》,此后各派琴谱均以王维的七言绝句《送元二使安西》为主要歌词,引申诗意,增添词句,抒发离愁别绪。本文主要对明代《新刊发明琴谱》中的琴歌《阳关三叠》进行打谱,从版本梳理入手,厘清调式律制、订制指法节奏,追溯此本的诗词内涵与结构风格,试图探究在弹唱过程中,如何让某一特定题材的琴歌作品之声曲韵达到平衡。从而最大程度的复原那个时代的声音。

摘要：With large-scale use of kinds of motors, oilfield drilling electrical system always accompanied by serious power quality problem, including reactive current, harmonics current and grid voltage distortion, which would greatly threaten the safety and proper working of the whole system. This paper focuses on a power quality improvement project to solve these problems. A hybrid compensating scheme, including an active compensator and a passive compensator, is carried out. Because of the specificity of oilfield drilling electrical system, compensators are redesigned against features of this application background. And then the current detection point arrangement of this hybrid system is also taken into consideration to build the whole system much more effective and reliable. Now the improvement project is already implemented in application field, and the power quality of the system is greatly improved.

摘要：陇南粗陶不仅是陇南传统手工艺的重要体现,还是传统文化的延续和体现,更是我国传统文化交往、交流与交融的有力见证。本文基于文献资料法、实践调查法等分析了陇南粗陶的经济价值、实用价值、艺术价值以及文化价值,从打造陇南粗陶文化创意产品、加强陇南粗陶技艺和教学的结合、打造陇南粗陶品牌以及创新人才培养体系等方面提出了推动陇南粗陶创新发展的途径。