摘要：Early detection of cancer biomarkers applied in real-time disease diagnosis and therapies can increase the survival rate of *** tumor DNA(ct DNA)as a typical cancer biomarker plays a great role in the process of tumor disease monitoring,especially in early ***,most ct DNA detection systems have not been widely used due to their low sensitivity,poor specificity,and high ***,we developed an alternative ct DNA detection system to present the levels of ct DNA by recording the fluorescence signals of the system containing upconversion nanoparticles(UCNPs),Fe_(3)O_(4),and entropy-driven strand displacement *** method has a practical sensitivity with a wide linear range from 100 amol L^(-1)to 1 nmol L^(-1)and a low detection limit of 1.6 amol L^(-1).Furthermore,the system demonstrates a practical application in mouse blood serum samples and meets the requirements for rapid,sensitive,specific,and economical diagnosis of ***,this ct DNA detection system may have great potential for ct DNAdetection and clinical diagnosis.

摘要：The design and synthesis of multifunctional nanocarriers for efficient synergistic cancer therapy have drawn great research interests in recent *** this work,a nanoplatform for chemo-photothermal therapy with targeting ligand was *** porous structured silica nanotubes(SNTs)with controllable lengths decorated with CuS nanoparticles(NPs)on the surface as photothermal agents were prepared and further conjugated with lactobionic acid groups as a cancer cell *** with average lengths of 40,55 and 150 nm were obtained and further functionalized as drug *** smallest bifunctional SNTs with targeting groups show good biocompatibility and highest cellular uptake for HepG2 *** release of doxorubicin hydrochloride(DOX)from the SNTs was dependent on the p H of the buffer solution and 808-nm near infrared(NIR)light *** integration of photothermal therapy(PTT)of CuS NPs and chemotherapy of anticancer drug leads to a better tumor inhibition effect than the individual therapy alone in vitro and in *** results demonstrate potential applications of the nanocomposites as vector for efficient chemo-photothermal therapy.

摘要：Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity,biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres(CuO@CNSs)with doxorubicin hydrochloride(DOX)loading were *** as photothermal agents were synthesized by a hydrothermal *** was adsorbed on the surface of CNSs,which improved the photothermal conversion efficiency due to the electron transitions between C-2 p and Cu-3 *** addition,CuO would release Cu2+ions in the tumor microenvironment,which could produce hydroxyl radical(·OH)to induce cancer cells apoptosis via Haber-Weiss and Fenton-like *** as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer *** CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy(PTT),chemodynamic therapy(CDT),and chemotherapy(CT),which have strong potential for cancer treatment.

摘要：近年来随着大规模全陷式煤炭开采,形成了很大范围的采空区,不仅造成河流规划、工程建设难度加大,而且对现有的水库工程安全和功能构成威胁。现行的《建筑物下、水下、铁路下及井巷煤柱留设与压煤开采规程》以最大限度开采煤炭资源为目标,水库安全煤柱留设按照充分采动、地表塌陷盆地边缘尽可能接近水体为原则,采用经验参数垂直断面图解法确定水库周边禁采范围边界线是不科学的,因未考虑到水库工程的特殊性而存在缺陷。本文初步分析了现行方法存在的主要问题,提出了合理的弥补措施,建议水利部门尽快研究制定相应规范,确定合理的安全煤柱留设依据,充分保障水库工程安全和效益的发挥。

摘要：河流泥沙及其处理是水利工作的一个难题,也是一门专业学科。在多泥沙河流上建设水能开发项目,对泥沙问题设计重视和研究不够,将会给工程运行带来严重后果。结合陕西省水能开发项目设计审查中常遇的相关泥沙问题,提出相应的对策供设计中研究参考。

摘要：通过室内相同条件下清水膜孔灌自由入渗和4种不同含沙率的浑水膜孔灌自由入渗试验,研究了不同含沙率对浑水膜孔灌自由入渗特性和灌水结束后湿润体内水分分布情况的影响,建立了浑水膜孔灌自由入渗参数、湿润锋运移参数和灌水结束后湿润体内水分分布曲线参数与不同含沙率的关系,提出了不同含沙率的浑水膜孔灌自由入渗单位膜孔面积累积入渗量模型、湿润锋运移模型和灌水结束后湿润体内水分分布曲线模型,以及不同含沙率的浑水膜孔灌自由入渗相对相同条件下清水膜孔灌自由入渗的减渗特性及其影响规律.结果表明:随着浑水含沙率的增大,累积入渗量逐渐减小,且均小于相同条件下的清水累积入渗量,入渗系数K随着含沙率的增大而减小,入渗指数α随着含沙率的增大而增大;在相同入渗时间内,随着浑水含沙率的增大,垂直和水平湿润锋运移距离都逐渐减小;灌水结束后湿润体内垂直方向和水平方向质量含水率均随着距膜孔中心距离的增大而逐渐减小;不同含沙率的浑水膜孔灌自由入渗与相同条件下清水对比具有减渗作用,随着含沙率的增大,减渗率逐渐增大.

摘要：以引大灌区为对象研究了渠塘供水模式下灌区信息管理系统的设计。该设计以充分利用渠塘联控调水模式、最大限度提高灌区水资源的利用率为目标,由监测子系统提供塘群、渠系水情等实时信息,基于B/S结构的信息管理系统将完成动态配水、GIS查询等功能,实现对塘水、渠水的信息化管理和调度,突出渠塘供水模式的特色,充分发挥塘的二次调蓄功能。

摘要：地处干旱缺水区的勤锋农场大面积推广应用滴灌技术,发挥了滴灌节水的优越性,是成功使用滴灌技术的典型,破解了滴灌技术在大田农作物上的使用难题。勤锋农场使用滴灌技术成功的主要原因是推广应用滴灌技术的推动机制有力,工程设计精良,管理制度措施到位,效益发挥得好,使用户尝到了应用滴灌技术的甜头。因此要推广应用好滴灌这项节水技术,就必须对工程进行精心设计,做好滴灌工程系统的配置,严格配水制度,严格管理制度,在滴灌设备装置区域不得使用其他灌水方式进行农作物灌溉,以保证滴灌技术的推广应用,保证滴灌设备正常效益的发挥。

摘要：新型弹性侧支撑长轨枕式减振轨道和既有轨枕式减振轨道的弹性支撑方式不同,重点对新型弹性侧支撑长轨枕式减振轨道力学特性和关键参数展开研究。在轮载作用条件下,对比分析两种减振轨道的应力分布情况,找出道床的应力集中区域及最不利位置,研究载荷施加在新型弹性侧支撑长轨枕式减振轨道不同位置时部件的应力分布特征,并对道床的减振特性加以研究。针对荷载作用于轨枕正上方时的最不利位置,进行道床承轨槽折角处的应力分布分析,以及减振轨道整体道床的配筋设计与检算。采用试验与仿真相结合的方发,研究了侧支撑式弹性垫板的厚度、空间倾斜量和材料硬度对轨枕节点动刚度和垂向最大位移的影响。研究结果表明,新型弹性侧支撑长轨枕式减振轨道道床的最大应力出现在承轨槽两侧下部靠近折角的区域,与既有轨枕式减振轨道的最大应力出现在承轨槽底部中间区域截然不同,且减振效果较显著。道床结构参考既有纵向承轨台整体式道床的配筋方案可以满足受力要求,承轨槽两侧下端折角处不会开裂。侧支撑式弹性垫板的厚度、空间倾斜量和材料硬度是影响新型弹性侧支撑长轨枕式减振轨道节点动刚度的三个关键,其中厚度和材料硬度的变化对节点动刚度的影响较大,增加侧垫厚度,降低材料硬度使节点动刚度降低,载荷-位移滞回曲线的面积增大,消耗的振动能量更多;空间倾斜量的影响较小,与节点刚度之间存在正比例变化关系;在三个关键参数的研究范围内取值可以获得满足规范要求,并具有不同减振等级的节点动刚度。

摘要：工业燃煤锅炉烟气中含有大量的飞灰颗粒、粘性物质和酸性气体,其中飞灰颗粒易与其他物质发生耦合作用,在换热器受热面上发生沉积而形成积灰,会对设备换热性能和系统稳定运行造成严重影响,因此积灰问题是亟待解决的难题。而影响积灰的因素众多,不同运行工况和换热器结构条件下,受热面上的积灰过程差异较大。为深入了解积灰特性和影响积灰的关键因素,首先阐述燃煤锅炉烟气中飞灰的形成、传输、粘附和生长机制;接着详细分析影响飞灰颗粒在换热器受热面上沉积的主要因素和影响规律,并归纳总结积灰对换热性能影响的准则关联式;最后,根据各种因素对积灰影响规律的分析,为高热效、抗积灰换热器的结构设计和运行工况选择提供指导思路,并对烟气侧换热表面积灰特性的研究前景进行展望。