摘要：利用计算机辅助药物设计(CADD)技术去探讨403个黄嘌呤氧化酶抑制剂作为治疗痛风药物的潜在可能性。本研究运用Surflex-Dock、FAF-Drugs2、Toxtree的Benigni/Bossa rulebase和PharmMapper对COX-1和COX-2进行柔性分子对接、ADMET预测、致癌性预测和潜在药物靶标预测研究。结果显示化合物ChEMBL 170303和460160有最高的药物潜在价值,可对其进行生物活体及临床研究以了解其确切功效,从而发掘能同时治疗高尿酸血症及炎症的新型抑制剂。

摘要：我的演讲题目是“数字‘桑巴舞’”，大家会想我是一个音乐家吗？人们常把巴西和桑巴舞联系起来，我从中也汲取过很多灵感。所以今天首先让我们来聆听去年夏天巴西最为盛行的热曲。

摘要：项目的建筑原身是一个旧仓库,设计师在设计的过程中,保留了建筑原有的语言和结构,再融入新的设计。在大门的入口处,logo标记通往商店内部的道路,引领着来访者进入空间,进入大楼内部,最明显感受到的是新与旧形成鲜明的对比,设计师选择白色作为空间的主色调,认为其更合适作为背景,来突出样式不同的陈列产品的个性,而不喧宾夺主。设计师通过这种方式,促进空间、产品、客户新体验和设计之间的关系。空间内部宽阔,并可以根据不同的使用需求进行灵活多变的转化,整体充满流动性,很好地向来访者展示着精心设计的产品。

摘要：如恩设计受开发商阿那亚Aranya之邀,在其开发的秦皇岛黄金海岸社区内设计一座艺术中心,业主的远见卓识为项目的设计赋予了充分的构思空间,如恩也希望借此契机,尝试突破艺术中心与公共空间的固有定义。阿那亚社区整体强调重新找回人的情感价值,以及与环境的和谐互融。因而,除了满足艺术展陈的功能外,如恩在建筑内部设计了一个环形的庭院,作为社区居民的公共活动空间。

摘要：工程师们在设计或确定两程或多程换热器时必须校正非逆流时的LMTD值(温差的对数平均值)。作者等人参考了许多文献的有关公式,总结出了关于计算温差校正因子(或称F因子)的一组方程。但更重要的是,本文将向大家介绍一个简单的方法来解这些计算方程。以前是采用迭代法来解这些方程,所以比较复杂、困难。

摘要：这家设计共和（Design Republic）新的旗舰店位于上海的中心，由一座上世纪初的英式红砖楼改造而成。是一个现代化的家具零售商，加之一系列以设计为重点的零售概念，包括书籍、服装、灯饰、配件和鲜花。公社同时设有一间设计画廊、一个活动空间、一间咖啡厅．一家由米其林星级厨师杰森阿瑟顿（Michelin-Starred Chef Jason Atherton）主厨的餐厅，和一间卧室的设计共和公寓。

摘要：阿尔蒙特剧院位于阿尔蒙特镇的“文化城”内，前身为一座葡萄酒酿造厂。正门对面并排有一处公共图书馆和一座艺术学校，三者环绕出一座公共广场。设计中面临的挑战来自于新建建筑与遗留下来的文化景点建筑的融合，既要尊重原有建筑的不同形态，又要展现出自身的强烈个性，让剧院能够自然的融合其中，成为文化综合体的一部分。建成之后将会成为阿尔蒙特镇的主要建筑和居民乐意前往的大型聚会场所。

摘要：Pollen Street Social餐厅坐落于伦敦名声显赫的梅菲尔（Mayfair）区，是名厨JasonAtherton的第一家独立餐卮JasonAtherton曾担任过GordonRamsay的米其林星级餐厅Maze的主厨。餐厅的设计来自于上海的多元化建筑设计事务所——如恩设计研究室。

摘要：The new properties of engineered nanoparti- cles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applica- tions, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation ofnanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles （Aeroxide~ P25）, two phase composition ofanatase （65%） and rutile （35%） with an average particle size value of 27.64-11 nm were used. Results on the ECs0 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease （p〈0.05） after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed.

摘要：The research on spatial epidemic models is a topic of considerable recent interest. In another hand, the advances in computer technology have stimulated the development of stochastic models. Metapopulation models are spatial designs that involve movements of individuals between distinct subpopulations. The purpose of the present work has been to develop stochastic models in order to study the transmission dynamics and control of infectious diseases in metapopulations. The authors studied Susceptible-Infected-Susceptible （SIS） and Susceptible-lnfected-Recovered （SIR） epidemic schemes, using the Gillespie algorithm, Computational numerical simulations were carried in order to explore the models. The results obtained show how the dynamics of transmission and the application of control measures within each subpopulation may affect all subpopulations of the system. They also show how the distribution of control measures among subpopulations affects the efficacy of these strategies. The dynamics of the stochastic models developed in the current study follow the trends observed in the classic deterministic designs. Also, the present models exhibit fluctuating behavior. This work highlights the importance of the spatial distribution of the population in spread and control of infectious diseases. In addition, it shows how chance could play an important role in these scenarios.