摘要：本文报告１７７例头颈部鳞癌术前诱导化疗的药物疗效。随机抽取３组病例，分别采用ＰＤ、ＤＯＰ、ＯＦＰ方案作诱导化疗。对三种方案的应用方法、疗效等作了分析比较，提出了每种方案的适应证。

摘要：Laminar optical tomography(LOT)is a mesoscopic tomographic imaging technique ranging between confocal microscopy and diffuse optical tomography(DOT).Fluorescence LOT(FLOT)provides depth-resolved molecular information with 100-200μm resolution over 2-3mm *** this study,we use Monte Carlo simulation and singular-value analysis(SVA)to optimize the source-detector configurations for potential enhancement of FLOT imaging *** effects of different design parameters,including source incidence and detector collection angles,detector number,and sampling density,are *** results indicate that angled incidence/detection configuration might improve the imaging resolution and depth sensitivity,especially for low-scattering *** the number of detectors and the number of scanning steps will also result in enhanced imaging *** also demonstrate that the optimal imaging performance depends upon the background scattering coe±*** result might provide an optimization strategy for FLOT or LOT experimental setup.

摘要：胰腺导管腺癌的肿瘤新生血管匮乏且基质丰富,限制了细胞毒性药物的递送效率,降低了治疗效果。纳米递送细胞毒性药物治疗胰腺癌有望克服其生物屏障,提高递药效率。而设计具有高效靶向胰腺癌细胞的纳米递药系统是克服上述生物屏障的关键。本文综述相关领域的最新进展,包括纳米递药系统的被动靶向设计、主动靶向设计及响应释放的靶向递药设计。

摘要：本文介绍了一次面向具体临床手术需求的综合解决方案设计。针对基本外科胰肠吻合术的临床治疗中医学影像三维可视化需求,本次研究设计并实现了针对胰腺的三维重建及手术方案模拟、手术植入支架个性化设计,并以此实验为基础实现了临床病例的术前三维重建及远程预览等综合应用解决方案。本项目是一次设计学科与工程学、医学专业等跨领域深度融合的设计研究,同时是面向学科会聚的多主体协同创新在实施路径精细化方向上的具体实践。

摘要：The works of Alvaro Siza have been referred that they were not the theoretical architecture but the sensual and experiential one. His works were designed on the base of their locality that each of them located. For the study, I selected a work of him, which was the Mimesis Art Museum at Paju in South Korea, and reviewed existing literatures to understand how he controlled the light and created the architectural spaces and forms in relation with the light, and I measured the illumination levels of the inside areas of the Mimesis Art Museum, and then, I surveyed the visitors’ responses on the lighting conditions of the Mimesis Art Museum. The results of the measurements showed that the illumination levels of the Mimesis Art museum on the first floor were effectively controlled to display the art works. The illumination levels on the third floor, however, were much higher than recommended illumination values for museum because of less controlled natural light. Therefore, more considerations to control the natural light are needed to secure stable environment in the exhibition spaces. Meanwhile, the answers of questionnaires concerning the quality of lighting conditions in the Mimesis Art Museum showed that the natural light was so effective to light the museum although the natural light illuminated some areas of the museum with high illumination levels.

摘要：急性髓系白血病(AML)总体治疗效果差,复发难治是其治疗失败的主要原因。复发难治性AML(R/R-AML)患者白血病细胞通常对常规化疗耐药,亟需新的治疗方案以进一步提高患者生存率及延长生存期。对于R/R-AML,除进入临床试验外,尚无推荐的统一治疗方案,目前主要以挽救化疗和造血干细胞移植(HSCT)为主,HSCT是目前唯一可能治愈的方法,但该类患者大多数预后仍差。近年来AML的治疗进展迅速,新的治疗方案层出不穷,多种新药成为研究的热点,并通过与原有化疗药物联合使用提高化疗敏感性、克服化疗耐药,取得了一定的进展,为R/R-AML患者的治疗提供了新的选择,改善了患者的整体预后。本文将对R/R-AML的治疗现状及新药研究最新进展作一综述。

摘要：As one masterpiece by Shakespeare,King Lear has been aroused a hot argument about its miserable ending since it come out to *** paper will take this controversial ending as the starting point,focus on the seemingly unfair ending of Lear and Cordelia’s tragic death and making a thorough textual study on its death *** a systematic and comprehensive analysis of the ending,I attempt to reveal the deep-seated significance behind the characters’forlorn *** death of Lear and Cordelia are not the absence of“poetic justice”,but an elaborate arrangement by *** the death of a series of characters,the playwright expresses his own understanding on human *** clearly makes his choice and assents the kindness of human nature.

摘要：前段时间微博微信上都疯传一个国外的公益广告，瑞典儿童癌症基金会在地铁站安放了一个显示屏，上面是一个有着靓丽长发的少女，当地铁进站时，看似静止的显示屏画面上，少女的头发会被风吹乱，人们看到这个场景时多半会心一笑，但是没想到之后的剧情来了个大反转，少女的头发被吹掉了，露出光头，这时字幕出现：“每天都有孩子被确诊癌症。发送短信捐助50元。”

摘要：As one of Crane’s most representative works,The Red Badge of Courage has been paid much attention to and studied by scholars at home and abroad from different perspectives since its *** for me,I’d like to study on human weaknesses in Henry in The Red Badge of Courage to give an analysis of the three main human weaknesses existing in Henry and explore the underlying *** will be of great benefit to promote our understanding of the novel from this angle,thus bringing us much practical significance.

摘要：建立超热中子束孔道筛选的三维扩散模型，并用蒙特卡罗程序 MCNP/4B验证了热柱孔道是实现超热中子束的最佳孔道，还建立了硼中子俘获治疗 (BNCT)所需超热中子束的理论设计方法，对超热中子束过滤材料的特性进行了分析，提出了将西安脉冲堆热柱孔道改造成超热中子束孔道的 3种材料组合方案。