摘要：Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,defined by several phases,ranging from benign fat accumulation to non-alcoholic steatohepatitis(NASH),which can lead to liver cancer and *** NAFLD is a disease of disordered metabolism,it also involves several immune cell-mediated inflammatory processes,either promoting and/or suppressing hepatocyte inflammation through the secretion of pro-inflammatory and/or anti-inflammatory factors to influence the NAFLD ***,the underlying disease mechanism and the role of immune cells in NAFLD are still under investigation,leaving many open-ended *** this review,we presented the recent concepts about the interplay of immune cells in the onset and pathogenesis of *** also highlighted the specific non-immune cells exhibiting immunological properties of therapeutic significance in *** hope that this review will help guide the development of future NAFLD therapeutics.