摘要：The structure and operating principle of micro valveless pump were investigated theoretically and experimentally. The mathematical model of pressure and flow rate within the micro nozzle/diffuser was established to analyze the effects of nozzle/diffuser parameters on the output flow rate of the micro valveless *** experiments were carried out with different structural parameters, driving frequencies, vibration amplitudes and stiffness of the driving diaphragms. Effects of the structural parameters and driving conditions on the operation performance of the pump are discussed in detail. The work provides useful reference for structure optimization selection of the driving diaphragm of micro valveless pump.

摘要：Subsolidus phase relationships in the system Ln2O3-Si3N4-AIN-AI2O3, where Ln represents Nd, Sm and Dy, were summarized, with emphasis on the region involving α-sialon, β-sialon and AIN-polytypoid phases. This information is further used in designing the compatible matrix phases of sialon materials with desirable properties. Examples were provided to illustrate the advantage of such a basic approach to materials design.

摘要：A new generation of storage ring-based light sources, called diffraction-limited storage rings（DLSR）, with emittance approaching the diffraction limit for multi-ke V photons by using multi-bend achromat lattice, has attracted worldwide and extensive studies of several laboratories, and been seriously considered as a means of upgrading existing facilities in the imminent future. Among various DLSR proposals, the PEPX design demonstrated that it is feasible to achieve sufficient ring acceptance for off-axis injection in a DLSR, by designing the lattice based on the ‘thirdorder achromat’ concept and with a special high-beta injection section. For the High Energy Photon Source（HEPS）planned to be built in Beijing, a PEPX-type lattice has been designed and continuously improved. In this paper, we report the evolution of the PEPX-type design for HEPS, and discuss the main issues relevant to the linear optics design and nonlinear optimization.

摘要：Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger than that of control compounds tetrahydroisoquinolines. The binding model of lead molecules in the active site of CYP51 of Candida albicans showed that lead compound specifically interacted with the amino acids residues in the active site, without binding with the heme of CYP51, which was different from azole antifungal drugs. The present study might afford a novel lead molecule to develop non-azole CYP51 inhihitars of fungi.

摘要：面孔视错觉现象表现为个体从其他事物中感知到并不存在的面孔。面孔视错觉要素已广泛应用于艺术、广告及商品中,起到吸引注意、促进消费的作用。同时,先前的研究通过采用各种范式,发现患者在面孔视错觉的产生上同常人的差异,以及视错觉与视幻觉之间的联系。根据视觉加工通路的不同,相关范式可分为视错觉监测范式,以及视错觉辨认范式。前者侧重于基于提取的类面孔特征所做出的快速预测,后者侧重于主观期望引导个体对物体特征的提取,两者最终均会影响到后续的认知判断。日后研究可从面孔视错觉的发生机制出发,结合自上而下和自下而上两种加工通路,为面孔视错觉产生机制提供理论依据,并拓宽该要素在临床诊断及商业广告领域上的应用。

摘要：In the present study, we have developed the method brought forward recently for protein design based on the relative entropy. The new approach can be used in more common situation other than the special limits in the anterior method. The results indicate that our generalized method has increased the prediction precision for protein sequence and will be in favor of the study for protein design.

摘要：为解决摩擦摆支座耗能能力低、抗拔性能差等问题,基于减隔震原理将阻尼器的屈曲特性与摩擦摆支座的力学特性相结合,提出了一种新型摩擦摆支座。该新型支座由复摩擦摆支座与两侧内外套设的双U型阻尼器组成,双U型阻尼器可提供抗剪刚度且具有耗能能力。首先介绍了新型支座的原理,随后建立有限元模型,研究了不同双U型阻尼器参数下新型支座的滞回曲线、有效刚度和耗能面积等力学特性。结果表明:通过控制阻尼器的平直段长度可以使新型支座实现分阶段耗能的目标;双U型阻尼器与复摩擦摆支座为并联关系,新型支座具有良好的耗能能力;双U型阻尼器的平直段长度、宽度和厚度对新型支座的滞回性能均有影响,内阻尼器较外阻尼器厚度变化对新型支座的滞回性能影响大。

摘要：Xi'an Jiaotong University (XJTU)has carded out the research of additive manufacturing (AM)since 1993,who is one of the earliest institutes majoring in *** 20years of effort,XJTU has made great progress on the additive manufacturing of polymer,metals,ceramics,composite materials and intelligent *** has established a research team that features the engineering application of rapid manufacturing system.

摘要：Twenty-three 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase. In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.

摘要：By integrating topology optimization and lattice-based optimization,a novel multi-scale design method is proposed to create solid-lattice hybrid structures and thus to improve the mechanical performance as well as reduce the structural *** achieve this purpose,a two-step procedure is developed to design and optimize the innovative ***,the classical topology optimization is utilized to find the optimal material layout and primary load carrying ***,the solid-lattice hybrid structures are reconstructed using the finite element mesh based modeling *** lattice-based optimization is performed to obtain the optimal crosssection area of the lattice ***,two typical aerospace structures are optimized to demonstrate the effectiveness of the proposed optimization *** numerical results are quite encouraging since the solid-lattice hybrid structures obtained by the presented approach show remarkably improved performance when compared with traditional designs.