摘要：Functional knowledge integration is the initial and core phase of a design process. It is the key phase to ensure that the functional requirement of the design product can be appropriately complied with, and its result is also the rudiment of the subsequent detailed design work. If this important phase can be supported by an increasingly distributed resource environment, and be automated such that its completion requires less manual work, the efficiency of the design process would be largely improved and its ability to promote innovation would be enhanced. Therefore, this study involved a detailed analysis of the functional knowledge integration of the design process, as well as the proposal of a corresponding running model. Based on the model, a computational algorithm and an evaluating method were established to automate functional knowledge integration. A corresponding computer program was developed to prove the feasibility of this approach, and it was used to design a solarpowered wiper blade.

摘要：Many dynamic optimal control models for advertising make efforts to solve the problem of determining optimal advertising expenditures and other variables of interest over time for a firm or several competing firms,However,after analyzing the extant literature,one can find that few dynamic optimal advertising models available consider the problem within the product diffusion ***,the established models involving product diffusion are inspired by the Bass model,which has been out of *** paper poses a dynamic optimal advertising model for new products,which considers the product diffusion based on the relative newly developed generalized version of the Bass *** this paper,the optimal control model is used to derive the optimal advertising expenditure policy,which gives some implications to advertising practice.

摘要：The intermediate heat exchanger for enhancement heat transfer is the important equipment in the usage of nuclear energy. In the present work, heat transfer and entropy generation of an intermediate heat exchanger(IHX) in the accelerator driven subcritical system(ADS) are investigated experimentally. The variation of entropy generation number with performance parameters of the IHX is analyzed, and effects of inlet conditions of the IHX on entropy generation number and heat transfer are discussed. Compared with the results at two working conditions of the constant mass flow rates of liquid lead-bismuth eutectic(LBE) and helium gas, the total pumping power all tends to reduce with the decreasing entropy generation number, but the variations of the effectiveness, number of transfer units and thermal capacity rate ratio are inconsistent, and need to analyze respectively. With the increasing inlet mass flow rate or LBE inlet temperature, the entropy generation number increases and the heat transfer is enhanced, while the opposite trend occurs with the increasing helium gas inlet temperature. The further study is necessary for obtaining the optimized operation parameters of the IHX to minimize entropy generation and enhance heat transfer.

摘要：Acidic oligosaccharide sugar chain （AOSC）, a D-mannuronic acid oligosaccharide, derived from brownalgaepolysaccharide, has been completed Phase I clinical trial in china as an anti-Alzheimer＇s Disease （AD） drug candidate. The identification of AOSC-binding protein（s） in neurons is very important for understanding its action mechanism. To determine the binding protein（s） of AOSC in neurons mediating its anti-AD activities, confocal microscopy, affinity chromatography, and liquid chromatography-tandem mass spectrometry （LC-MS/MS） analysis were used. Confocal microscopy analysis shows that AOSC binds to SH-SY5Y cells in concentration-, time-, and temperature-dependent fashions. The AOSC binding proteins were purified by affinity chromatography and identified by LC-MS/MS analysis. The results showed that there are 349 proteins binding AOSC, including clathrin, adaptor protein-2 （AP-2） and amyloid precursor protein （APP）. These results suggest that the binding/entrance of AOSC to neurons is probably responsible for anti-AD activities.

摘要：The heat exchanger network(HEN) synthesis problem based on entransy theory is analyzed. According to the characteristics of entransy representation of thermal potential energy, the entransy dissipation represents the irreversibility of the heat transfer process, the temperature difference determines the entransy dissipation, and four HEN design steps based on entransy theory are put forward. The present study shows how it is possible to set energy targets based on entransy and achieve them with a network of heat exchangers by an example of heat exchanger network design for four streams. In order to verify the correctness of the heat exchanger networks design method based on entransy theory, the synthesis of the HEN for the diesel hydrogenation unit is studied. Using the heat exchange networks design method based on entransy theory, the HEN obtained is consistent with energy targets. The entransy transfer efficiency of HEN based on entransy theory is 92.29%, higher than the entransy transfer efficiency of the maximum heat recovery network based on pinch technology.

摘要：This paper addresses the synchronization problem of Boolean *** on the matrix expression of logic,solvability conditions and design procedures of the synchronization of Boolean networks with outputs are given for both open-loop and feedback *** and sufficient conditions on open-loop control are proposed first with a constructive design *** sufficient condition for the feedback control case is obtained,and corresponding design procedure is proposed with the help of algorithms to solve logic matrix *** examples are also provided to illustrate the proposed control design.

摘要：Time-series photometry was made for the large-amplitude δ Scuff star AD CMi in 2005 and 2006. High-quality photometric data provided in the literature were used to analyze the pulsation of the star, with the derived multiple frequencies fitted to our new data. Besides the dominant frequency and its harmonics, one low frequency （2.27402 c d^-1） is discovered, which provides a reasonable interpretation for the long-noticed luminosity variation at the maximum and minimum light. Combining the nine new times of light maxima determined from the new data with the 64 times collected from the literature, we analyzed the long-term variability of AD CMi with the O - C technique. The results provide the updated value of period of 0.122974478 days, and seem to be in favor of the model of combination of the evolutionary effect and light-time effect of a binary system, of which some parameters are hereby deduced.

摘要：We investigate the area and entropy spectra of D-dimensional large Schwarzschild black holes. By utilizing the new physical interpretation of quasinormal mode frequency we find that a large Schwarzschild-AdS black hole has an equally spaced area spectrum and an equidistant entropy spectrum; both are dependent on the spacetime dimension.

摘要：Restricted genetic diversity can supply only a limited number of elite genes for modern plant cultivation and *** this study,we demonstrate that rational design enables the engineering of geranyl-geranyl diphosphate synthase(NtGGPPS),an enzyme of the methylerythritol phosphate pathway(MEP)in the model plant Nicotiana *** the crucial bottleneck in carotenoid biosynthesis,NtGGPPS1 interacts with phytoene synthase(NtPSY1)to channel GGPP into the production of *** of this enzyme in the ntggpps1 mutant leads to decreased carotenoid *** the aim of enhanc-ing NtGGPPS1 activity,we undertook structure-guided rational redesign of its substrate binding pocket in combination with sequence *** activity of the designed NtGGPPS1(a pentuple mutant of five sites V154A/I161L/F218Y/I209S/V233E,d-NtGGPPS1)was measured by a high-throughput colorimetric assay.d-NtGGPPS1 exhibited significantly higher conversion of IPP and each co-substrate(DMAPP~1995.5-fold,GPP~25.9-fold,and FPP~16.7-fold)for GGPP synthesis compared with wild-type ***,the transient and stable expression of d-NtGGPPS1 in the ntggpps1 mutant increased carotenoid levels in leaves,improved photosynthetic efficiency,and increased biomass relative to *** findings provide a firm basis for the engineering of GGPPS and will facilitate the development of quality and yield *** results open the door for the structure-guided rational design of elite genes in higher plants。

摘要：The martensitic transformation temperature is the basis for the application of shape memory alloys(SMAs),and the ability to quickly and accurately predict the transformation temperature of SMAs has very important practical *** this work,machine learning(ML)methods were utilized to accelerate the search for shape memory alloys with targeted properties(phase transition temperature).A group of component data was selected to design shape memory alloys using reverse design method from numerous unexplored *** modeling and feature modeling were used to predict the phase transition temperature of the shape memory *** experimental results of the shape memory alloys were obtained to verify the effectiveness of the support vector regression(SVR)*** results show that the machine learning model can obtain target materials more efficiently and pertinently,and realize the accurate and rapid design of shape memory alloys with specific target phase transition *** this basis,the relationship between phase transition temperature and material descriptors is analyzed,and it is proved that the key factors affecting the phase transition temperature of shape memory alloys are based on the strength of the bond energy between *** work provides new ideas for the controllable design and performance optimization of Cu-based shape memory alloys.