摘要：本文介绍了一种基于横向可移动栅极场效应晶体管(LMGFET)的新型微型力传感器的开发。提出了一种精确的电气模型,用于小型LMGFET器件的性能评估,与以前的模型相比,其精度有所提高。采用了一种新型三明治结构,该结构由一个金交叉解耦栅阵列层和两个软光阻层SU-8组成。通过所提出的双差分传感结构,LMGFET横向工作在垂直干扰下的输出电流被大大消除,所提出传感器的相对输出误差从4.53%(传统差分结构)降低到0.01%。提出了一种实用的传感器制造工艺,并对其进行了模拟。基于LMGFET的力传感器的灵敏度为4.65μA·nN^(-1),可与垂直可移动栅极场效应晶体管(VMGFET)器件相媲美,但非线性度提高了0.78%,测量范围扩大了±5.10μN。这些分析为LMGFET器件的电气和结构参数提供了全面的设计优化,并证明了所提出的传感器在生物医学显微操作应用中具有良好的力传感潜力。

摘要：In pre-clinical phase of new drug development,it is particularly important to establish an in vitro model to mimic the metabolism situation of human *** aim of the in vitro model is to reduce the usage of experimental animals and to make a more accurate prediction of the drug metabolism in *** chip is an emerging technology to establish predictive *** integrating subcellular fractions,hepatocytes or liver tissue in the microfluidic chips,more predictive in vitro metabolism models can be established for drug *** microfluidic platform offers dynamic and controlled fluids,as well as sophisticated liver tissue assembly to remodel the physiological and pathological microenvironment of liver in the human *** review updates the microfluidic-based liver drug metabolism models since 2011,and summarizes the development of different models based on different chip vectors(subcellular components,primary hepatocytes,and tissue sections).It serves as a guide for newcomers to this dynamic field.

摘要：Brain growth charts and age-normed brain templates are essential resources for researchers to eventually contribute to the care of individuals with atypical developmental *** present work generates age-normed brain templates for children and adolescents at one-year intervals and the corresponding growth charts to investigate the influences of age and ethnicity using a common pediatric neuroimaging *** accelerated longitudinal cohorts with the identical experimental design were implemented in the United States and *** magnetic resonance imaging(MRI)of typically developing school-age children(TDC)was obtained up to three times at nominal intervals of1.25 *** protocol generated and compared population-and age-specific brain templates and growth charts,respectively.A total of 674 Chinese pediatric MRI scans were obtained from 457 Chinese TDC and 190 American pediatric MRI scans were obtained from 133 American ***-and age-specific brain templates were used to quantify warp cost,the differences between individual brains and brain *** growth charts for labeled brain network areas were *** analyses of cost functions supported the necessity of age-specific and ethnicitymatched brain templates,which was confirmed by growth chart *** analyses revealed volumetric growth differences between the two ethnicities primarily in lateral frontal and parietal areas,regions which are most variable across individuals in regard to their structure and ***-and ethnicity-specific brain templates facilitate establishing unbiased pediatric brain growth charts,indicating the necessity of the brain charts and brain templates generated in *** templates and growth charts as well as related codes have been made freely available to the public for open neuroscience(https://***/zuoxinian/CCS/tree/master/H3/Growth Charts).

摘要：针对无线移动通信的特点,提出了一种在移动IPv6网络中保障用户通信服务质量的资源预留新方案Fast RSVP.该方案采用跨层设计的思想,将两个不同层次的模块:移动IPv6模块和RSVP模块结合起来,通过在两个模块之间增加一些原语使得二者配合工作以保证移动用户的通信业务质量.Fast RSVP方案引入了邻居隧道提前资源预留、优化路径资源预留、切换预留、路径融合等一系列新机制.仿真实验结果表明,与其他移动环境中的RSVP扩展方案相比,该Fast RSVP方案在支持无线移动通信方面具有如下优势:(1)能够实现移动节点带有服务质量保证的快速切换;(2)能够避免移动IP切换过程中三角路由和重复预留造成的资源浪费;(3)能够区分不同类型的切换预留请求,在保证网络整体性能的前提下显著降低因为切换而导致的服务中断率.

摘要：[Objective] The research aimed to optimize the test condition of PCR-DGGE method to analyze genetic diversity of soil microorganism. [Method] The amplified results of PCR were compared by improving high salt method for extracting soil DNA, improving primer design, changing the annealing temperature and amplification system of PCR reaction process. [Result] The result of extracting soil micro-bial DNA was better by high salt method which was improved. A single band was obtained and operation was easy when choosing 20 μl system for PCR amplification. There was no nonspecific amplification when choosing annealing temperature at 55 ℃, and cycle number of 35 was easy for following DGGE analysis. [Conclusion] The optimized PCR reaction system has high specificity and reliability.

摘要：基于弹塑性断裂力学的裂纹扩展机理,用弹塑性有限元分析压载荷对LY12M铝合金疲劳裂尖应力场的影响。介绍了可用于负应力比试验数据描述的两种实际应用的工程模型和一种已发表的称作"张模型"的双参数裂纹扩展模型,通过在相应坐标系下描述试验数据,并比较各自拟合线的线性相关度R2。结果验证"张模型"的拟合效果较好,是一种负应力比下预测铝合金疲劳裂纹扩展寿命的较好的工程方法,同时,由于部分参数可用弹塑性有限元计算获得,所以可节省大量新材料研究的经费。

摘要：目的:研究膀胱癌相关Livin基因在膀胱移行细胞癌组织中的表达以及Livin基因表达与膀胱移行癌生物学行为的关系;研究抑癌基因p53在膀胱癌组织中突变以及Livin表达与p53基因突变的关系。方法:100例膀胱移行细胞癌组织,设计Livinα引物,以半定量RT-PCR的方法,检测膀胱癌组织Livinα mRNA,以免疫组化法检测癌组织中p53蛋白。将膀胱肿瘤病理分级、临床分期、是否复发等生物学行为及p53蛋白染色强度分别量化,与组织Livinα mRNART-PCR产物量进行等级相关分析。并以10例正常膀胱黏膜作为对照。结果:100例膀胱移行细胞癌,67例检测到Livinα mRNA表达,10例正常膀胱黏膜组织未检测到Livinα mRNA表达,Livinα mRNA在膀胱移行细胞癌组织中表达率高于正常膀胱黏膜,χ2=14.4,P=0.000。Livinα mRNA在膀胱癌组织中表达与p53蛋白阳性(rs=0.465,P=0.002)及肿瘤病理分级(rs=0.463,P=0.002)有相关性。结论:膀胱移行细胞癌组织中可见Livinα mRNA高表达,Livinα mRNA表达与膀胱癌病理分级及癌组织中p53蛋白呈正相关。

摘要：一般情况下,每年冬季是季节性流感高发季节,但在当前2019冠状病毒病(COVID-19)大流行期间,全球季节性流感活动呈“断崖式”下降。为应对即将到来的流感季节,亟需弄清这种前所未有的流感低水平流行的原因。本文中,我们探索了一种国家特异性推理模型,利用该模型估计中国、英国和美国这三个国家中佩戴口罩、人员流动变化(国际和国内)以及严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)干扰的影响。结果发现,在这些地区增加一周佩戴口罩的干预措施,流感活动可减少11.3%~35.2%。实施一周的限制人员流动措施对国际(1.7%~6.5%)和国内社区(1.6%~2.8%)的影响较小。2020年至2021年,仅佩戴口罩这一项干预措施就可使阳性率下降13.3%至19.8%。仅人员流动变化可使阳性率降低5.2%至14.0%,其中79.8%~98.2%归因于国际旅行限制。SARS-CoV-2干扰仅在2019年至2020年具有统计学显著效应。中国北方地区及英国的阳性百分比分别降低7.6%(2.4~14.4)和10.2%(7.2~13.6)。探索所得出的结果对了解非药物干预措施和其他呼吸系统疾病背景下的流感演变有一定意义,有助于制定卫生政策,并可为公共卫生措施的个性化设计提供信息。

摘要：According to the Chapman multi-scale rock physical model, the seismic response characteristics vary for different fluid-saturated reservoirs. For class I AVO reservoirs and gas-saturation, the seismic response is a high-frequency bright spot as the amplitude energy shifts. However, it is a low-frequency shadow for the Class III AVO reservoirs saturated with hydrocarbons. In this paper, we verified the high-frequency bright spot results of Chapman for the Class I AVO response using the frequency-dependent analysis of a physical model dataset. The physical model is designed as inter-bedded thin sand and shale based on real field geology parameters. We observed two datasets using fixed offset and 2D geometry with different fluid- saturated conditions. Spectral and time-frequency analyses methods are applied to the seismic datasets to describe the response characteristics for gas-, water-, and oil-saturation. The results of physical model dataset processing and analysis indicate that reflection wave tuning and fluid-related dispersion are the main seismic response characteristic mechanisms. Additionally, the gas saturation model can be distinguished from water and oil saturation for Class I AVO utilizing the frequency-dependent abnormal characteristic. The frequency-dependent characteristic analysis of the physical model dataset verified the different spectral response characteristics corresponding to the different fluid-saturated models. Therefore, by careful analysis of real field seismic data, we can obtain the abnormal spectral characteristics induced by the fluid variation and implement fluid detection using seismic data directly.

摘要：Over the past several decades,the utilization of fossil fuels is responsible for mainly excessive atmospheric carbon dioxide(CO_(2))[1-3].Increased concentration of CO_(2)contributes to the major portion of the critical issues faced worldwide,such as global warming and drastic changes in ***,it is imperative to develop an alternative technology that is capable of providing an efficient and sustainable pathway to target the neutralization of CO_(2)level in the atmosphere.