摘要：Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted *** address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of *** GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 *** analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the *** with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and ***,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three *** addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude *** evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was *** research therefore acts as a foundation for the application of 3DP-7721 models in drug devel

摘要：通讯技术不断升级以及移动设备的快速发展极大改善了人们生活,但也带来了电磁干扰和信息安全问题.因此,亟需开发高性能电磁屏蔽材料来抑制电磁辐射和阻止信息泄露.研究发现,在外力作用下填料的自取向行为有助于实现聚合物基复合材料电磁屏蔽性能的提升,因此如何在聚合物基体中构筑有效的填料取向结构正成为电磁屏蔽材料研究的热点.本文首先关注外场诱导复合材料内导电网络的构建策略.随后,梳理了利用外场诱导无机填料取向制备聚合物基电磁屏蔽复合材料的研究进展,其中外场包括温度场、静电场、重力场、机械力场和磁场.值得注意的是,基于外场诱导制备的独特结构与电磁波之间的特殊响应关系通过精选的案例被进一步剖析.最后,提出外场辅助制备聚合物基电磁屏蔽复合材料各自亟待解决的关键科学和技术问题,并对未来的发展方向进行了理性预测.本文讨论的方法和提出的策略有望为高性能聚合物基电磁屏蔽复合材料的创新设计提供一些指导意见.

摘要：Flexible wearable sensors with excellent electric response and self-powered capability have become an appealing hotspot for personal healthcare and human-machine ***,based on triboelectric nanogenerator(TENG),a flexible self-powered tactile sensor composed of micro-frustum-arrays-structured polydimethylsiloxane(PDMS)film/copper(Cu)electrodes,and poly(vinylidenefluoride-trifluoroethylene)(P(VDF-TrFE))nanofibers has been *** TENG-based self-powered tactile sensor can generate electrical signals through the contact-separation process of two triboelectric layers under external mechanical *** to the uniform and controllable micro-frustum-arrays structure fabricated by micro-electro-mechanical system(MEMS)process and the P(VDF-TrFE)nanofibers fabricated by electrostatic spinning,the flexible PDMS-based sensor presents high sensitivity of 2.97 V kPa^-1,stability of 40,000 cycles(no significant decay),response time of 60 ms at 1 Hz,low detection pressure of a water drop(~4 Pa,35 mg)and good linearity of 0.99231 in low pressure *** the PDMS film presents ultra-flexibility and excellent-biocompatibility,the sensor can be comfortably attached on human ***,the tactile sensor can recognize various types of human body movements by the corresponding electrical ***,the as-prepared TENGs are potential on the prospects of gesture detection,health assessment,human-machine interfaces and so on.