摘要：The effects of water/binder ratio （w/b） on the toughness behavior, compressive strength and flexural strength of engineered cementitious composites （ECC） were investigated. The w/b ratios of 0.25, 0.31, 0.33 and 0.37 were selected and the specimens were tested at the ages of 7 d and 28 d. The experimental results showed that there was a corresponding increase in first cracking strength, modulus of rupture, compressive strength and flexural strength with the decrease of w/b. Within the w/b range of 0.25-0.37, higher w/b was found to have improved effects on deflection, strain hardening index and toughness index of ECC. In the permission of meeting the requirement of compressive strength grade, selecting higher w/b in mix design will help to obtain robust ECC.

摘要：A novel series of eight SMS and sPLA2 dual inhibitors containing indole and a-amino cyanide fragments of different length and substitution position was synthesized and evaluated by three different in vitro assays. Biological evaluation showed that all compounds provided inhibitory effects against SMS （about 50% inhibition at 100 μmol/L） and sPLA2 （14-32 μmol/L）. All the compounds had the SMS activity better than the positive control compound D609 in SMS2 homogenate, with compounds 5b and fie ideal for liver homogenate and SMS2 high expression cell homogenate, respectively.

摘要：Background Chronic obstructive pulmonary disease(COPD)is a severe public health *** smoke(CS)is a risk factor for COPD and lung *** underlying molecular mechanisms of CS-induced malignant transformation of bronchial epithelial cells remain *** this study,we describe a lung-on-a-chip to explore the possible mechanistic link between cigarette smoke extract(CSE)-associated COPD and lung *** An in vitro lung-on-a-chip model was used to simulate pulmonary epithelial cells and vascular endothelial cells with *** levels of IL-6 and TNF-αwere tested as indicators of inflammation using an enzyme-linked immune sorbent *** junction complex mRNA expression was detected with qRT-PCR as the index of epithelial-to-mesenchymal transition(EMT).The effects of CSE on the phosphorylation of signal transduction and transcriptional activator 3(STAT3)were detected by Western *** cytometry was performed to investigate the effects of this proto-oncogene on cell cycle *** Inflammation caused by CSE was achieved in a lung-on-a-chip model with a mimetic *** exposure induced the degradation of intercellular connections and triggered the EMT *** exposure also activated the phosphorylation of proto-oncogene STAT3,while these effects were inhibited with *** CSE exposure in the lung-on-a-chip model caused activation of STAT3 in epithelial cells and endothelial ***0152,an inhibitor of activated STAT3,could be a potential treatment for CS-associated COPD and lung cancer.

摘要：The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep *** microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise *** this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain *** results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned *** addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the ***,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN *** with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned *** may be a cause of sleep and motor disorders associated with ***,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

摘要：A new framework for free-form surface design is proposed. Using manifolds can generalize the spline scheme to surfaces of arbitrary topology. Physics-based modeling incorporate physical laws into shape representation to provide direct shape interaction. The combination presents a new method inherits the attractive properties of the manifold surface as well as that of the physics-based models.

摘要：Polarimetry plays an important role in the measurement of solar magnetic fields. We devel- oped a high-sensitivity and high-accuracy polarimeter （HHP） based on nematic liquid crystal variable retarders （LCVRs）, which has a compact setup and no mechanical moving parts. The system design and calibration methods are discussed in detail. The azimuth error of the transmission axis of the polarizer as well as the fast axes of the two LCVRs and the quarter-wave plate were determined using dedicated procedures. Linearly and circularly polarized light were employed to evaluate the performance of the HHP. The experimental results indicate that a polarimetric sensitivity of better than 5.7 × 10-3 can be achieved by using a single short-exposure image, while an accuracy on the order of 10-5 can be reached by using a large number of short-exposure images. This makes the HHP a high-performance system that can be used with a ground-based solar telescope for high-precision solar magnetic field investigations.

摘要：为实现远距情况下的实际应用,对赝热源鬼成像进行了从透射到反射的实验研究.首先利用CCD的两个独立区域分别探测参考光和信号光,得到双缝的透射型鬼成像,继而利用一个CCD和一个独立的桶探测器分别探测参考臂和物臂的光强信息,通过对没有空间分布的物臂光强和没有经过物体而有空间分布的参考臂光强信号进行关联计算实现透射和反射鬼成像.为设计和研制能进行现场应用的样机系统,以透射结构为例,对成像结果与系统各参数之间的关系进行了详细的对比实验研究,结果表明通过增加采样率、增大光强、适当调节快门时间和光阑大小可以提高成像的分辨率和可见度.

摘要：青藏高原东部的高山森林是长江上游的重要生态屏障。然而,由于近几十年来持续的高强度采伐,大量的人工种植,以及完全的禁伐等措施,导致树木种类与年龄结构变得相对单一,生物多样性和生态功能都有所下降。为设计有效的森林管理方案,以优化森林结构,提高森林碳汇能力,本研究以四川茂县为研究地点,利用LANDIS-II模型对6种不同强度的森林管理方案(采伐、种植)进行测试,模拟和比较了这些方案与当前管理方案在未来100年间森林地上固碳速率的差异。研究结果表明:(i)与目前的管理方案相比,不同强度的采伐和种植明显改变了森林地上固碳速率;(ii)不同群落对管理方案的反应不同,不同的管理方案对寒温带针叶林和温带针叶林的地上固碳速率有显著的影响(P<0.05),但对阔叶林影响较小;(iii)应综合物种、群落和景观3个层面全面考虑森林管理方案。这些结果说明,在研究地点实施较长的采伐和种植间隔(20年)可以最大限度地提高森林的地上固碳速率。该研究为评估森林管理方案在恢复森林生态和增加碳汇功能的能力,以及为在青藏高原东部地区选择有效的森林管理方案提供了重要参考。

摘要：Proteins carry out their functions by interacting with other proteins and small molecules, forming a complex interaction network. In this review, we briefly introduce classical graph theory based protein-protein interaction networks. We also describe the commonly used experimental methods to construct these networks, and the insights that can be gained from these networks. We then discuss the recent transition from graph theory based networks to structure based protein-protein interaction networks and the advantages of the latter over the former, using two networks as examples. We further discuss the usefulness of structure based protein-protein interaction networks for drug discovery, with a special emphasis on drug repositioning.

摘要：The High Resolution Model Intercomparison Project(HighResMIP)is a unique model intercomparison project in phase 6 of the Coupled Model Intercomparison Project(CMIP6),which is focused on the impact of horizontal *** outputs of the high-and low-resolution versions of CAS FGOALS-f3-H and CAS FGOALS-f3-L for the experiments of the HighResMIP simulations in CMIP6 are described in this *** models and their configurations,experimental settings,and postprocessing methods are all *** FGOALS-f3-H,with a 0.25°horizontal resolution,and CAS FGOALS-f3-L,with a 1°horizontal resolution,were forced by the standard external conditions,and two coordinated sets of simulations were conducted for 1950–2014 and 2015–50 with the Experiment IDs of‘highresSST-present’and‘highresSST-future’,*** model outputs contain multiple time scales including the required hourly mean,three-hourly mean,six-hourly transient,daily mean,and monthly mean *** is reported that the 0.25°CAS FGOALS-f3-H successfully simulates some of the key challenges in climate modeling,including the average lifetime of tropical cyclones,particularly in the western parts of the northern Pacific Ocean,and the diurnal cycle of hourly *** datasets will contribute to the benchmarking of current models for CMIP,and studies of the impacts of horizontal resolutions on climate modeling issues.