摘要：在底层网络通信协议中使用内存映射机制为用户层应用提供了虚拟网络界面，使用户层能够方便地访问快速通信设备；通过减少系统软件的协议处理开销，有效地减少了网络通信的延迟．讨论了通信协议中的内存映射机制的设计思想和实现过程，提出了通信区的概念，利用通信区有效地完成核心与用户之间的数据交换．同时给出一个实例，对其实现与性能进行了分析．

摘要：IntroductionA rapidly increasing need for organ transplantation and short list of donated organs have led to the development of new materials and technologies for organ manufacturing. Although some simple organs, such as skin and cartilage, have been successfully fabricated and commercialized, it is still difficult to make tissues and organs with high complexity. Engineered tissues have other biomedical applications, such as drug screening models and bio-actuators. Threedimensional （3D） bioprinting has become a great tool to fabricate tissue constructs on demand for transplantation and other biomedical applications.

摘要：Irregular craniofacial bone defects caused by craniofacial fractures always result in craniofacial bone and contour asymmetry and should therefore be ***(PEEK)is an ideal substitute for autologous bone grafts and has been widely used in craniofacial bone defect *** precise design of custom-made PEEK implants is particularly important to optimise ***,the workflow and principles for the design and manufacture of PEEK implants are summarised,and a protocol for the precise design of an irregular craniofacial bone defect PEEK implant is *** to the method and principles,the design flow was efficient and could be standardised,and design errors could be avoided as much as possible.

摘要：Background:When patients with cirrhosis develop ascites,it is associated with sharply increasedmortality and healthcare utilization with decreased quality of *** salt restriction is first-line therapy for ascites but it is limited by poor ***:We will recruit 40 patients with cirrhosis and ascites who have received a recent paracentesis or hospitalization for a 1:1 randomized trial of standard care(education on salt restriction)versus home-delivered *** primary outcome is the number of paracenteses needed over 12 *** outcomes include hospital-bed days,health-related quality of life(HRQOL,Ascites Symptom Inventory-7 and Visual Analogue Scale)and performance on batteries of physical function including hand grip(kg)and walk speed(m/s).All subjects follow up through a series of calls where any paracenteses,hospital readmissions,weight changes and diuretic dosage changes are *** a final Week 12 visit,knowledge of dietary sodium intake,quality of life and frailty are reassessed,and satisfaction with the meal-delivery program is *** comparison testing will be conducted between the two ***:A nutritionally standardized meal-delivery program for patients with cirrhosis and ascites post discharge has a variety of potential patient-based benefits,including the effective management of ascites,reduction of healthcare utilization and improvement of *** have three core ***,patients will report interest in and satisfaction with a home-delivered meals ***,subjects on a salt-restricted(2 g sodium)meal-delivery program will have fewer therapeutic paracenteses and all-cause readmissions than subjects receiving standard of ***,subjects on a saltrestricted(2 g sodium)meal-delivery program will report increased HRQOL compared to subjects receiving standard of care.

摘要：Overview and research infrastructure As one of the leading laboratories in the interdisciplinary field of additive manufacturing and bio-3D printing,the Bio-Manufacturing Center at Tsinghua University is highly dedicated to conducting cutting-edge research in the emerging field of *** latter is comprised of research involving biomaterials,living cells,proteins,and/or other biological compounds as basic building blocks to fabricate biomimetic structures,in vitro functional biological models and/or cellular systems with application to tissue engineering,regenerative medicine,disease pathogenesis,drug screening,and tissue/organ-on-a-chip.

摘要：Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals in the general population. During the last two decades, relevant progress has been made in identifying chromosomal regions and genes in linkage or association with autism, but no single gene has emerged as a major cause of disease in a large number of patients. The purpose of this paper is to discuss specific methodological issues and experimental strategies in autism genetic research, based on fourteen years of experience in patient recruitment and association studies of autism spectrum disorder in Italy.

摘要：Polypharmacology,which focuses on designing drugs to target multiple receptors,has emerged as a new paradigm in drug *** rationally design multi-target drugs,it is fundamental to understand protein-ligand interactions on a proteome *** have developed a Proteome-wide Off-target Pipeline （POP） that integrates ligand binding site analysis,protein-ligand docking,the statistical analysis of docking scores,and electrostatic potential *** utility of POP is demonstrated by a case study,in which the molecular mechanism of anti-cancer effect of Nelfinavir is *** combining structural proteome-wide off-target identification and systems biology,it is possible for us to correlate drug perturbations with clinical outcomes.

摘要：Weani ng from mechanical ventilation in the in tensive care unit (ICU) is a complex clinical problem and relevant for future organ engineering. Prolonged mechanical ventilation (MV) leads to a range of medical complications that increases length of stay and costs as well as contributes to morbidity and even mortality and long-term quality of life. The need to reduce MV is both clinical and economical. Artificial intelligence or machine learning (ML) methods are promising opportunities to positively influence patient outcomes. ML methods have been proposed to enhance clinical decisions processes by using the large amount of digital information generated in the ICU setting. There is a particular interest in empirical methods (such as ML) to improve management of "difficult-to-wean" patients, due to the associated costs and adverse events associated with this population. A systematic literature search was performed using the OVID, IEEEXplore, PubMed, and Web of Science databases. All publications that included (1) the application of ML to weaning from MV in the ICU and (2) a clinical outcome measurement were reviewed. A checklist to assess the study quality of medical ML publications was modified to suit the critical assessment of ML in MV weaning literature. The systematic search identified nine studies that used ML for weaning management from MV in critical care. The weaning management application areas included (1) prediction of successful spontaneous breathing trials (SBTs),(2) prediction of successful extubation,(3) prediction of arterial blood gases, and (4) ventilator setting and oxygenation-adjustment advisory systems. Seven of the nine studies scored seven out of eight on the quality index. The remaining two of the nine studies scored one out of eight on the quality index. This scoring may, in part, be explained by the publications' focus on technical novelty, and therefore focusing on issues most important to a technical audience, instead of issues most impor

摘要：Alzheimer’s disease(AD)is a prominent form of dementia,characterized by aggregation of the amyloidβ-peptide(Aβ)plaques and neurofibrillary tangles,loss of synapses and neurons,and degeneration of cognitive ***,although a variety of medications can relieve some of the symptoms,there is no cure for *** breakthroughs in the stem cell field provide promising strategies for AD *** cells including embryonic stem cells(ESCs),neural stem cells(NSCs),mesenchymal stem cells(MSCs),and induced pluripotent stem cells(iPSCs)are potentials for AD ***,the limitation of cell sources,safety issues,and ethical issues restrict their applications in ***,the direct reprogramming of induced neural progenitor cells(iNPCs)has shed light on the treatment of *** this review,we will discuss the latest progress,challenges,and potential applications of direct reprogramming in AD treatment.

摘要：为了减少月球探测任务设计阶段的开发成本、提高研究效率,提出利用成熟软件卫星工具包(Satellite tool kit,STK)进行分析、设计及验证的一般途径。首先,讨论基于微分改正的月球探测器轨道设计方法。然后,分析利用STK验证圆锥曲线拼接法设计结果的问题及注意事项。最后,针对STK中月面点、月球车运动设置不灵活等问题,利用外部文件导入方式进行分析、验证;在此基础上,给出月面点光照和测控条件分析方法。仿真结果表明,所提出的方法可以有效实现STK对月球探测任务的分析、设计及验证。