摘要：Diesel particulate matter （DPM） is considered to be carcinogenic after prolonged exposure. With more diesel- powered equipment used in underground mines, miners＇ exposure to DPM has become an increasing concern. This paper used computational fluid dynamics method to study the DPM dispersion in a dead-end entry with loading operation. The effects of different push-pull ventilation systems on DPM distribution were evaluated to improve the working conditions for underground miners. The four push-pull systems considered include： long push and short pull tubing; short push and long pull tubing, long push and curved pull tubing, and short push and curved pull tubing. A species transport model with buoyancy effect was used to examine the DPM dispersion pattern with unsteady state analysis. During the 200 s of loading operation, high DPM levels were identified in the face and dead-end entry regions. This study can be used for mining engineer as guidance to design and setup local ventilation, select DPM control strategies and for DPM annual training for underground miners.

摘要：为使石化企业大量的低温余热得到充分利用,以某12万t/a加工重油的催化裂化中试装置单元存在的低温余热作为研究对象,采用问题表格法讨论了该系统最小传热温差ΔTmin对最小公用工程加热负荷QH,min的影响,得到最佳的ΔTmin为15℃,在此ΔTmin下,该过程最小公用工程加热负荷QH,min为409 364.10 kW,所需的最小公用工程冷却负荷QC,min为163 763.95kW。介绍了夹点技术,换热网络设计采用夹点之上的设计和夹点之下2步分别优化,并得到最终的综合换热网络。

摘要：T-cell receptor （TCR）-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR- engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR- engineered T cells to target New York esophageal squamous cell carcinoma （NY-ESO-1）. These successes demonstrate the potential of this approach to treat cancer. In this review, we provide a perspective on the current and future applications of TCR-engineered T cells for the treatment of cancer. Our summary focuses on TCR activation and both pre-clinical and clinical applications of TCR-engineered T cells. We also discuss how to enhance the function of TCR-engineered T cells and prolong their longevity in the tumor microenvironment.

摘要：对适用于稳压器人孔密封的结构方案进行分析,研究密封垫材料的功能性参数,利用数值分析手段对密封结构进行初步分析。在上述基础上,开展了楔形石墨密封结构1:1热态性能考核验证试验。试验结果表明,该密封结构在经历100次冷热循环试验考核后无泄漏,拆装过程简便。热态试验验证了该型密封结构具有工程应用可行性。

摘要：The high incidence of cardiovascular disease has led to significant demand for synthetic vascular grafts in clinical ***-proliferation drugs are usually loaded into devices to achieve desirable anti-thrombosis effects after ***,the non-selectiveness of these conventional drugs can lead to the failure of blood vessel reconstruction,leading to potential complications in the long *** address this issue,an asymmetric membrane was constructed through electro-spinning *** bilayer membrane loaded and effectively released nitric oxide(NO),as hoped,from only one *** to the short diffusion distance of NO,it exerted negligible effects on the other side of the membrane,thus allowing selective regulation of different cells on both *** released NO boosted the growth of endothelial cells(ECs)over smooth muscle cells(SMCs)-while on the side where NO was absent,SMCs grew into *** overall structure resembled a native blood vessel,with confluent ECs as the inner layer and layers of SMCs to support *** addition,the membrane preserved the normal function of ECs,and at the same time did not exacerbate inflammatory *** preparing this material type that regulates cell behavior differentially,we describe a new method for its application in the cardiovascular field such as for artificial blood vessels.

摘要：设计并搭建各向同性的多孔介质颗粒无序堆积的实验平台,针对由直径分别为60、70 mm的有机玻璃圆管和2、4、6、8 mm的不锈钢圆球所组成的多孔介质通道开展氮气-水两相工况下通道内流动特性的实验研究。实验结果表明,在液体流量一定的情况下,实验段压降随管径的增大而减小,随颗粒直径的减小而增大,随气相流量的增大而增大;在管径一定的情况下,实验段压降随颗粒直径的增大而减小。通过拟合获得了本实验条件下的两相压降关联式。

摘要：出于使用功能的考虑,在多高层结构中多层楼板抽空后形成通高区。在通高区内,外筒框架柱无任何面外支撑,其面外失稳常常控制结构的设计。该文针对通高区多层群柱的基本组成单元——两层两跨的十字型刚架中轴压柱的面外稳定性能进行了研究,提出了其面外稳定性设计方法。首先,剖析了十字型刚架中轴压柱发生面外失稳的主要影响因素,并按照面外支撑刚度相等的原则提出了等效研究模型,即柱跨中带侧向弹簧支撑的轴压柱。然后,通过对等效模型的弹性屈曲研究发现:当弹簧支撑刚度K低于其弹性临界值K e,th,柱子的屈曲荷载随弹簧刚度K线性增加;而当K≥Ke,th时,柱子的屈曲荷载保持不变。据此特征该文建立了柱子的屈曲荷载和计算长度系数与柱跨中弹簧刚度K的简化关系式,并给出了弹性临界支撑刚度K e,th的计算公式。最后,通过对等效模型的弹塑性极限承载力研究,验证了采用该文提出的计算长度系数计算公式并结合我国钢结构设计规范中柱子稳定曲线对轴压柱进行稳定性设计是适合的,但对中小长细比的柱子太过富裕。同时,极限承载力研究还发现了等效研究模型弹塑性失稳对应临界支撑刚度K u,th弱于弹性柱子对应的K e,th,而且当实际支撑刚度小于K u,th时,柱子的稳定系数也表现为随弹簧刚度线性变化。通过深入剖析,提出了K u,th的计算公式,并基于此建立了更加简便、精确的轴压柱稳定性简化设计公式,从而构建起了一种新的设计方法。

摘要：设计合成并评价了一系列他克林-丁苯酞杂合物作为多功能胆碱酯酶(ChE)抑制剂治疗阿尔茨海默病的活性.结果表明,他克林-丁苯酞杂合物对两种胆碱酯酶均表现出抑制活性.其中3-丁基-6-((7-((1,2,3,4-四氢吖啶-9-基)氨基)庚基)氧基)异苯并呋喃-1(3H)-酮(10b)显示出最优的乙酰胆碱酯酶(AChE,IC50=38.65nmol·L-1)抑制活性,高于他克林(IC50=200.70 nmol·L-1)约5倍. 3-丁基-6-((8-((6-氯-1,2,3,4-四氢吖啶-9-基)氨基)庚基)氧基)异苯并呋喃-1(3H)-酮(10g)显示出最好的丁酰胆碱酯酶(BuChE,IC50=33.69nmol·L-1)抑制活性,其值与他克林(IC50=27.12nmol·L-1)相似,高于多奈哌齐(IC50=7530nmol·L-1)约220倍.在大鼠海马体神经元细胞Aβ诱导损伤模型中,测试化合物对大鼠海马神经元细胞(Rat hippocampal neurons)中ROS水平的影响,结果显示,大多数化合物均能对Aβ1-42诱导的大鼠海马体神经元细胞分泌的ROS产生抑制作用.

摘要：基于纵向耦合五换能器结构,采用41°YX-LiNbO3基片材料,通过优化设计,研制出中心频率232MHz,3dB带宽23.5MHz的声表面波滤波器。该产品的插入损耗-3dB,相对带宽达到10.1%,矩形系数小于2.5,阻带抑制大于40dB,产品综合性能指标优异,有很好的实用性。

摘要：Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are two of the leading causes of chronic intestinal conditions in the world. This issue of World Journal of Gastroenterology (WJG ) presents a series of papers from world experts who discuss the current knowledge and opinions on these important conditions. Although great strides have been made in the diagnosis, treatment and pathology of IBS and IBD; much has yet to be explained. The etiologies and risk factors of these multifactorial conditions remain elusive. Specific diagnostic biomarkers need to be developed and safer treatments developed. The burden of IBS and IBD on the healthcare system is felt with repeated medical care visits and high costs. IBS and IBD patients can account for 30%-50% of office visits at gastroenterology services/clinics. Over one million people have IBD in the United States, with 30 000 new cases being diagnosed every year. One-quarter million people in the UK are afflicted with IBD. The cost of medical care in the United States for IBD is estimated to be $1.8 billion/year.