摘要：Of late, the relevance of silk in a myriad of material science and b.otechnological realms has b.en realized, as attested b. the incessantly clamb.ring numb.r of reports and patents in the scienti fic repositories. The write-up is geared off with a scrutiny into the pertinence of the b.sic nano-structural features of silk, christened as the ‘queen of textile’ for exemplary b.oengi- neering applications including designing and fab.ication of devices for micro fluidics, opto fluidics, chemo/b.o sensing, etc. Then, the major thrust of this short review is directed towards comprehending the prospects of using silk-b.sed b.omaterials (e.g. sca ffolds, electrospun memb.anes, films, hydr.gels, b.oinks) for tissue engineering and regenerative medicine as well as targeted delivery of various b.omolecular cargoes/therapeutic agents, etc., as vouched b. few avant-garde endeavours of the recent years. The write-up is entwined with a discussion on the various factors that could plausib.y hinder the realization of silk as the next-generation nanob.omaterial, suggestions for some approaches to dodge and deal with the practical snags and what lies ahead!