摘要：Although numerical simulation tools are now very powerful,the development of analytical models is very important for the prediction of the mechanical behaviour of line contact structures for deeply understanding contact problems and engineering *** the line contact structures widely used in the engineering field,few analytical models are available for predicting the mechanical behaviour when the structures deform plastically,as the classic Hertz’s theory would be ***,the present study proposed an elastic-plastic model for line contact structures based on the understanding of the yield mechanism.A mathematical expression describing the global relationship between load history and contact width evolution of line contact structures was *** proposed model was verified through an actual line contact test and a corresponding numerical *** results confirmed that this model can be used to accurately predict the elastic-plastic mechanical behaviour of a line contact structure.

摘要：Single cell temperature difference of lithium-ion battery(LIB) module will significantly affect the safety and cycle life of the battery. The reciprocating air-flow module created by a periodic reversal of the air flow was investigated in an effort to mitigate the inherent temperature gradient problem of the conventional battery system with a unidirectional coolant flow with computational fluid dynamics(CFD). Orthogonal experiment and optimization design method based on computational fluid dynamics virtual experiments were developed. A set of optimized design factors for the cooling of reciprocating air flow of LIB thermal management was determined. The simulation experiments show that the reciprocating flow can achieve good heat dissipation, reduce the temperature difference, improve the temperature homogeneity and effectively lower the maximal temperature of the modular battery. The reciprocating flow improves the safety, long-term performance and life span of LIB.

摘要：Following several damaging earthquakes in China, research has been devoted to find the causes of the collapse of reinforced concrete （RC） building sand studying the vulnerability of existing buildings. The Chinese Code for Seismic Design of Buildings （CCSDB） has evolved over time, however, there is still reported earthquake induced damage of newly designed RC buildings. Thus, to investigate modern Chinese seismic design code, three low-, mid- and high-rise RC frames were designed according to the 2010 CCSDB and the corresponding vulnerability curves were derived by computing a probabilistic seismic demand model （PSDM）.The PSDM was computed by carrying out nonlinear time history analysis using thirty ground motions obtained from the Pacific Earthquake Engineering Research Center. Finally, the PSDM was used to generate fragility curves for immediate occupancy, significant damage, and collapse prevention damage levels. Results of the vulnerability assessment indicate that the seismic demands on the three different frames designed according to the 2010 CCSDB meet the seismic requirements and are almost in the same safety level.

摘要：文章提出了一种由屈曲圆板和线性弹簧组成的隔振器,采用解析法和有限元法分别计算分析其屈曲模态,结果表明解析法与有限元法计算结果相吻合,验证了解析法的正确性。此外,通过采用有限元ANSYS软件计算分析其高静低动的刚度特性,验证了隔振器结构设计的合理性。最后,建立了高静低动隔振器的非线性动力学模型,进一步采用谐波平衡法分析其幅频特性,讨论了系统设计参数的影响规律。分析结果表明刚度比与隔振器的类型和非线性程度相关;此外,高静低动隔振器显示出具有典型的Duffing振子的频率跳跃现象。

摘要：Chimeric antigen receptors(CARs) are artificial recombinant receptors that generally combine the antigen-recognition domain of a monoclonal antibody with T cell activation domains. Recent years have seen great success in clinical trials employing CD19-specific CAR-T cell therapy for B cell leukemia. Nevertheless, solid tumors remain a major challenge for CAR-T cell therapy. This review summarizes the preclinical and clinical studies on the treatment of solid tumors with CAR-T cells. The major hurdles for the success of CAR-T and the novel strategies to address these hurdles have also been described and discussed.

摘要：As a green and sustainable technology,heterogeneous photocatalysis using semiconductors has received much attention during the past decades because of its potential to address energy and environmental problems. Among various semiconductors,TiO2 has been regarded as the best and most widely investigated photocatalyst in the past 10 years. Based on the fundamentals of photocatalysis and surface chemistry of TiO2 nanomaterials,we herein summarize and discuss the achievements in the different surface modification strategies employed to date such as surface doping and sensitization,construction of surface heterojunctions,loading of nano-sized co-catalysts,increase in the accessible surface areas,and usage of surface F effects and exposure of highly reactive facets. Especially,the interesting synergistic effects of these different surface modification strategies deserve more attention in the near future. Studying these important advances in photocatalysis fundamentals,and surface chemistry and modification may offer new opportunities for designing highly efficient TiO2-based and non-TiO2-based photocatalysts for solar fuel production,environmental remediation,organic photosynthesis,and other related fields such as solar cell device fabrication,thermal catalysis,and separation and purification.

摘要：Based on the height of back-filled materials, thickness of ore body, height of boundary pillar and dipping angle of ore body and water pressure, the safety factors of all the pillars are calculated with the limit equilibrium method. The calculation results present that the safety factors of pillars in Sections 19, 20, 24, 28 are less than 1.3, and those of unstable sections are identified preliminarily. Further, a numerical investigation in Sections 18, 20, 22, 24, 25 and 28 implemented with numerical code RFPA20 is employed to further validate the pillar performance and the stability of stopes. The numerical results show the pillars in Sections 18, 22 and 24 are stable and the designed pillar size is suitable. The width of the ore body near Section 28 averages 20 m, failure occurs in the left stope, but the boundary pillars near Section 28 maintain good performance. The pillars in Sections 20 and 25 are unstable which are mainly affected by the Faults F8 and F18. The existence of faults alters the stress distribution, failure mode and water inrush pathway. This work provides a meaningful standard for boundary pillar and stope design in a mine as it transitions from an open pit to underground.

摘要：风载荷是海洋平台设计载荷之一,直接关系到平台稳性,确定平台在不同工况下的风荷载对于平台安全设计具有重要的工程意义。该文基于Fluent软件结合自编UDF程序,考虑Davenport、NPD以及API三种典型风谱的影响,利用简谐波叠加法将风谱由频域转换为时域内的随机脉动风速,引入雷诺平均法求解NS方程结合分离涡(DES)湍流模型对半潜式钻井服务支持平台在自存海况下的风力和风倾力矩开展了数值研究,并将数值模拟得到的最大风力及风倾力矩与ABS、DNV以及CCS的计算结果进行了对比验证。计算结果表明:平台受到的风力和风倾力矩与风谱自身特性、平台倾斜角及风向角等因素密不可分;同一工况下采用Davenport与NPD风谱计算时平台受到的平均风力(矩)较为接近;NPD风谱作用时平台受到的随机最大风力(矩)最大;采用API与NPD风谱计算时,各工况下最小风力(矩)随风向角的变化趋势、计算结果均基本一致。

摘要：Flotation indexes gradually decrease with the increase of cycle time of the backwater in bauxite floatation,and discharge of backwater brings environmental *** this study,methods such as Fenton-oxidation,adsorption and coagulation were used in the treatment of backwater,the flotation indexes were checked after backwater treatments,and Box-Behnken design(BBD)was used in the optimization of the main operating *** results reveal that flotation indexes are effectively improved after coagulation treatment by polyaluminum ferric chloride(PAFC).The optimum parameters predicted by BBD are pH 7.55,1.09 g/L PAFC dosage and temperature of 25℃.Under these optimum conditions,a maximum recovery of Al2O3 of 82.83%and a minimum A/S of 1.30 of tailings are gained,while the deviations are less than 3%from the predicted *** findings encourage the application of BBD for the optimization of critical parameters in backwater treatment.

摘要：In order to study the application of gyratory compaction molding method in emulsified asphalt cold recycled mixture and optimize the relevant technical parameters, the study was carried out according to splitting strength, stability and water stability test;the design of the experiment involved changing gyration number, emulsified asphalt and water content, molded specimen temperature and other factors to analyze the volume parameters, mechanical properties and water stability. The results show that both the maximum dry density and dry and wet splitting strength ratio(DWSSR) of emulsified asphalt cold reclaimed mixture are improved by the rotary compacting method, while the porosity and the optimal dosage of water are reduced. Furthermore, with the increase of compaction times, the porosity and splitting strength index both change exponentially. DWSSR and porosity are consistent with quadratic functions. The use of gyratory compaction for 70 times at 25 °C and the optimum dosage of emulsified asphalt can be determined based on the splitting strength ratio. The high-temperature stability and water damage resistance of the pavement can be improved by the use of rotary compacting method effectively, and the early strength and road performance are higher than the regulatory requirements.