摘要：The design of a tunable metal-coated long-period fiber grating （LPFG） filter based on the material dispersion consideration is presented. The tuning of the resonant wavelength can be achieved by heating the metal layer. Based on the coupled mode theory, the influences of the material dispersion on the transmission spectrum of the metalcoated LPFG are studied. There is a special grating period for a specific cladding mode; when the grating period is less than or equal to the special grating period, the material dispersion has weak influence on the resonant wavelength. Under such condition, the attenuation band depth corresponding to the specific cladding mode has excellent stability while the temperature changes, thus improving the filtering performances of the tunable loss filter. Further, experimental results demonstrate the validity and feasibility of the proposed tunable filter.

摘要：Based on digital signal processing theory,a novel method of designing optical notch filter is proposed for Mach-Zehnder interferometer with cascaded optical fiber rings coupled *** method is simple and effective,and it can be used to implement the designing of the optical notch filter which has arbitrary number of notch points in one free spectrum range(FSR).A design example of notch filter based on cascaded single-fiber-rings is *** this basis,an improved cascaded double-fiber-rings structure is presented to eliminate the effect of phase shift caused by the single-fiber-ring *** new structure can improve the stability and applicability of *** change of output intensity spectrum is finally investigated for each design parameter and the tuning characteristics of the notch filter are also discussed.

摘要：Based on the theory of one-dimensional photonic crystal,an asymmetrical interleaver filter composed of thin-film glass cavities is *** thin-film glass cavities are cascaded in the *** cavity is formed by evaporating several layers of reflecting films on two surfaces of the glass *** with other proposed structures,this interleaver filter is very simple and easy to realize,and it has flat passband and stopband.A design example of a 50 GHz interleaver filter with the duty cycle of 1:5 is *** influence of the structural parameters of each reflecting film(including the glass cavity) on the spectral performance is *** the design results with duty cycles of 1:3 and 1:4 are also shown and analyzed.

摘要：A high-sensitivity metal-coated long-period fiber grating(LPFG) sensor based on material dispersion is *** on the coupled mode theory,the influence of the material dispersion on the dual-peak characteristics of the metal-coated LPFG is *** considering the material dispersion,the jumping region of the dual-resonant-wavelength shifts toward the thinner film thickness,and the sensitivity of the dual-peak metal-coated LPFG sensor to liquid refractive index(RI) can be obtained to supply accurate parameter ***,two kinds of silver-coated LPFGs with different film thicknesses and grating periods are fabricated to monitor the salt solution,and the sensitivities of these two sensors are *** experimental results are consistent with the theoretical analyses.

摘要：The syntheses and preliminary biological evaluation of a potentially bioreductive A-mustard and paclitaxel conjugate prodrug 3 targeting hypoxic tumor tissue are described. Aromatic nitro group was used as the bio-reductive trigger. Generation of paclitaxel occurred after reduction via a subsequent mechanism of ＂cyclization-cyclization-extrusion＂. The prodrug was stable in PBS （pH = 7.4） and released paclitaxel after chemical reduction of the nitro fimctionality. In aerobic cytotoxicity assays, it exhibited diminished cytotoxicity and is a candidate for further biological evaluation.

摘要：氧化还原电动势是了解核酸中电荷/电子转移过程以及设计具有新型氧化还原活性的碱基类化合物的重要参数.本文对82个芳香化合物的氧化还原电动势进行理论预测,通过计算值和实验值的比较发现:气相采用B3LYP/6-311++G(2df,2p)//B3LYP/6-31+G(d)方法,液相采用HF-COSMORS/UAHF方法,对运用HF-CPCM/UAHF方法在水相重新优化的构型计算溶剂化能,能有效预测芳香化合物水相氧化还原电动势,该理论方法计算的绝对均方根误差(RMSD)为0.124V.运用该理论方法成功预测了属于芳香化合物的核酸碱基及其代谢物的水相氧化还原电动势.根据预测结果,讨论了核酸中电荷/电子转移过程以及结构改变对设计具有新型氧化还原活性的核酸碱基类化合物的影响.本文为设计具有氧化还原活性的新型核酸碱基类化合物提供了一种理论方法.

摘要：研究简单随机截距模型中固定和随机效应线性组合的估计和个体未来观测值的预测的最优设计问题.在模型的方差分量假定为已知的情况下,分别利用估计量的均方误差和预测量的预测均方误差建立设计准则,给出若干最优设计测度的解析解或精确设计数值算法.