摘要：The recently emerging laser-induced graphene(LIG)technology,with one-step processing and designable features,has been widely used in the fabrication of wearable/portable ***,by taking inspiration from kirigami,we designed a stretchable supercapacitor(SC)step by step through controlling laser induction and cutting process on the polyimide(PI)film,with the use of one single CO_(2) laser ***,the carbonized basic geometric units of lines were produced on PI films to investigate the processing-structure ***,the complex photothermal conversion and heat transfer progress involved in the carbonized process were simulated by a photothermal *** experimental and theoretical results suggested that the laser power,scan rate and focus condition have great influence on the size,shape and morphology of the carbonized ***,we optimized the parameters of laser induction and cutting process to fabricate the kirigami-inspired SCs with reliable electrochemical properties and editable mechanical flexibility,showing great potential in the field of flexible electronics.

摘要：Touch-sensitive screens are crucial components of wearable *** such as reduced graphene oxide(rGO),carbon nanotubes(CNTs),and graphene offer promising solutions for flexible touch-sensitive ***,when stacked with flexible substrates to form multilayered capacitive touching sensors,these materials often suffer from substrate delamination in response to deformation;this is due to the materials having different Young’s modulus *** results in failure to offer accurate touch screen *** this work,we demonstrate an induced charge-based mutual capacitive touching sensor capable of high-precision touch *** is enabled by electron trapping and polarization effects related to mixed-coordinated bonding between copper nanoparticles and vertically grown graphene ***,we used an electron cyclotron resonance system to directly fabricate graphene-metal nanofilms(GMNFs)using carbon and copper,which are firmly adhered to flexible *** being subjected to 3000 bending actions,we observed almost no change in touch *** screen interaction system,which has a signal-to-noise ratio of 41.16 dB and resolution of 650 dpi,was tested using a handwritten Chinese character recognition trial and achieved an accuracy of 94.82%.Taken together,these results show the promise of touch-sensitive screens that use directly fabricated GMNFs for wearable devices.

摘要：Exorbitant aldosterone is closely associated with various severe diseases,including congestive heart failure and chronic kidney *** aldosterone synthase is the pivotal enzyme in aldosterone biosynthesis,its inhibition constitutes a promising treatment for these *** a structure-based approach,a series of pyridyl substituted 3,4-dihydrobenzo[f][1,4]oxazepin-5(2 H)-ones were designed as inhibitors of aldosterone *** compounds(5 j,5 l,5 m 5 w,5 x and 5 y)distinguished themselves with potent inhibition(IC50<100 nmol/L)and high selectivity over homogenous 11β-*** the most promising compound,5 x exhibited an IC_(50) of 12 nmol/L and an excellent selectivity factor(SF)of157,which are both superior to those of the re ference fadrazole(IC_(50)=21 nmol/L,SF=7).Importantly,5 x showed no inhibition against steroidogenic CYP17,CYP19 and a panel of hepatic CYP enzymes indicating an outstanding sa fety *** it manifested satis factory pharmacokinetic pro perties in rats,compound5 x was considered as a drug candidate for further development.

摘要：Fail-safe topology optimization is valuable for ensuring that optimized structures remain operable even under damaged *** selectively removing material stiffness in patches with a fixed shape,the complex phenomenon of local failure is modeled in fail-safe topology *** this work,we first conduct a comprehensive study to explore the impact of patch size,shape,and distribution on the robustness of fail-safe *** findings suggest that larger sizes and finer distribution of material patches can yield more robust fail-safe ***,a finer patch distribution can significantly increase computational costs,particularly for 3D *** keep computational efforts tractable,an efficient fail-safe topology optimization approach is established based on the framework of multi-resolution topology optimization(MTOP).Within the MTOP framework,the extended finite element method is introduced to establish a decoupling connection between the analysis mesh and the topology description *** examples demonstrate that the developed methodology is 2 times faster for 2D problems and over 25 times faster for 3D problems than traditional fail-safe topology optimization while maintaining similar levels of robustness.

摘要：A new method for patterned sapphire substrate （PSS） design is developed and proven to be reliable and cost-effective. As progress is made with LEDs＇ luminous efficiency, the pattern units of PSS become more complicated, and the effect of complicated geometrical features is almost impossible to study systematically by experiments only. By employing our new method, the influence of pattern parameters can be systematically studied, and various novel patterns are designed and optimized within a reasonable time span, with great improvement in LEDs＇ light extraction efficiency （LEE）. Clearly, PSS pattern design with such a method deserves particular attention. We foresee that GaN-based LEDs on these newly designed PSSs will achieve more progress in the coming years.

摘要：Microorganisms have been the main sources for the production of *** of chemicals requires the development of low-cost and higher-yield *** this goal,microbial strains with higher levels of production should be first *** engineering has been used extensively over the past two to three decades to increase production of these *** in omics technology and computational simulation are allowing us to perform metabolic engineering at the systems *** combining the results of omics analyses and computational simulation,systems biology allows us to understand cellular physiology and characteristics,which can subsequently be used for designing ***,we review the current status of metabolic engineering based on systems biology for chemical production and discuss future prospects.

摘要：The design of compliant hinges has been extensively studied in the size and shape level in the *** paper presents a method for designing the single-axis flexure hinges in the topology *** kinds of hinges,that is,the translational hinge and the revolute hinge,are *** basic optimization models are developed for topology optimization of the translational hinge and the revolute hinge,*** objective for topology optimization of flexure hinges is to maximize the compliance in the desired direction meanwhile minimizing the compliances in the other *** constraints for accomplishing the translational and revolute requirements are *** popular Solid Isotropic Material with Penalization method is used to find the optimal flexure hinge topology within a given design *** results are performed to illustrate the validity of the proposed method.

摘要：This paper describes the design and control of a portable and lightweight knee exoskeleton for people with knee *** knee exoskeleton is designed based on our custom quasi-direct drive actuation composed of a DC motor unit and a transmission mechanism encompassing three *** online gait generation method based on gait step calculation and direct measurement using Inertial Measurement Unit(IMU)sensors is proposed to provide continuous assistance during *** on the generated gait trajectory online,Active Disturbance Rejection Control(ADRC)incorporating the feedforward compensation approach is proposed to help the human leg move in consideration of external *** developed knee exoskeleton has been employed successfully to assist impaired users with knee dysfunction to walk in a health recovery *** experimental results indicate that the online gait generation method and the proposed control method are suitable for the knee *** maximum value of the target knee angular position is approximately 50°and the mean of the control torque for the knee joint is located in the interval of[−2 Nm,4 Nm].The developed knee exoskeleton has the potential to regain normal gait to improve strength and endurance during walking in their activities of daily life.

摘要：提出了一种简化的、能指导复合式能量采集器中磁致伸缩发电效应、电磁发电效应的最优性能输出的理论模型。在模型的建立过程中,首先研究了应力和磁场对Tb_(0.3)Dy_(0.7)Fe_(2)合金压磁效应的影响,讨论了单独应力和单独磁场作用下磁致伸缩材料内磁通密度的变化特性;其次,提出了基于预加载荷方法和基于冲击应力方法的理论模型思路,并分别探讨了2种模型建立方法在复合式能量采集器设计中最大压磁系数获取的准则;最后,完成了能量采集器的大压磁系数获取方法的可靠性试验,实验结果与理论设计的结果吻合较好。该模型能够快速、准确地获得不同应用环境下复合式能量采集器的压磁特性,并可用于获取大压磁系数的复合式能量采集器构造及设计。

摘要：A new substrate,aligned Ag nanowires decorated with silver nanoparticle composite structure(AgNWs@AgNPs),was fabricated to investigate metalenhanced fluorescence(MEF) and its *** new composite structure was fabricated via a three-phase interface assembly method followed by SnCl2 sensitization and AgNO3 reduction *** size and distribution of the nanoparticles on silver nanowires increased with the sensitization and reduction *** formation of AgNPs on the surfaces of AgNWs was confirmed by multiple characterization methods including scanning electron microscopy(SEM),transmission electron microscope(TEM),atomic force microscopy(AFM) and X-ray diffraction(XRD).The results show that the fluorescence intensity of the poly(3-hexylthiophene)(P3HT) on the composite structure was greatly enhanced compared with that on bare glass substrate,and the intensity increased with the increase in particle sizes and *** mechanism was basedo n the increase in excitation rate and the radiation decay *** new type of substrate could serve as a good and efficient MEF substrate for high-performance fluorescence-based devices.