摘要：The government subsidy plays an important role in the recycling and remanufacturing process of a closed-loop supply *** paper focuses on the impacts of different patterns of government subsidy on the chain members'profits and the ***,we develop three models in a supply chain including a manufacturer,a retailer and a collector,namely(1)the government invests public service advertisement to stimulate the remanufacturing process(Model AS);(2)the government offers only monetary subsidy to the collector(Model MS);(3)the government allocates the subsidy into two parts,namely both advertisement and monetary subsidy(Model HS).We find that,no matter which subsidy pattern the government adopts,both the manufacturer and the collector are beneficiaries of the government subsidy,and that such subsidizing activity is definitely conducive to the environmental *** into account the chain members,profits and the environmental impact,the optimal hybrid subsidy scheme(Model HS)is more beneficial than that in both Model MS and Model AS,which can be attributed to the combination of the incentives provided by the public service advertisement and the price attraction by the monetary *** also find that,for single advertisement and monetary subsidy,the amount of government subsidy will decide their merits and *** direct monetary subsidy in Model MS will have a greater influence regarding to the supply quantity of used products than the mere advertisement subsidy in Model AS when the subsidy is relatively large.

摘要：Direct methanol fuel cell(DMFC)has great potential to replace the traditional battery in the field of portable power *** study investigates the operational and structural aspects of a vapor-feed semi-passive DMFC supplied with concentrated *** effectiveness of using vaporous methanol to improve the cell performance is experimentally *** indicate that there exits an optimal value of methanol concentration that favors both methanol supply and control of methanol crossover(MCO).With the increase in vaporization temperature,the cell performance can be *** on the traditional structural design,a sintered porous metal plate is further used to depress the impact of MCO so that the cell performance can be significantly improved at a relatively higher methanol *** is of great importance to enhance the energy density and operating duration for portable *** mechanisms related to the performance behaviors are discussed in detail.

摘要：Functional performance variations of products and systems are often used to measure the qualities of products and systems considering the changes in the design parameter values caused by uncertainties.A robust design approach has been developed in this research to minimize the functional performance variations considering the design parameter uncertainties by identifying the boundaries of the functional performance variations through *** this work,a mathematical model is developed to describe the relationships among functional performance,design configurations and parameters,and design parameter uncertainties.A multi-level optimization model is established to identify:(1)The optimal design configuration,(2)the optimal values of design parameters,and(3)the boundaries of functional performance *** analysis considering the impact of parameter uncertainties on functional performance variation boundaries has also been conducted.A case study on the design of a truss system has been *** study results show that the sensitivities of functional performance variation boundaries to the design parameter uncertainties can be reduced significantly using the new robust design approach.

摘要：This paper presents an anthropomorphic prosthetic hand using flexure hinges, which is controlled by the surface electromyography （sEMG） signals from 2 electrodes only. The prosthetic hand has compact structure with 5 fingers and 4 Degree of Freedoms （DoFs） driven by 4 independent actuators. Helical springs are used as elastic joints and the joints of each finger are coupled by tendons. The myoelectric control system which can classify 8 prehensile hand gestures is built. Pattern recognition is employed where Mean Absolute Value （MAV）, Variance （VAR）, the fourth-order Autoregressive （AR） coefficient and Sample Entropy （SE） are chosen as the optimal feature set and Linear Discriminant Analysis （LDA） is utilized to reduce the dimension. A decision of hand gestures is generated by LDA classifier after the current projected feature set and the previous one are ＂pre-smoothed＂, and then the final decision is obtained when the current decision and previous decisions are ＂post-smoothed＂ from the decisions flow. The prosthetic hand can perform prehensile postures for activities of daily living and carry objects under the control of EMG signals.

摘要：当前,高渗透性反渗透膜材料的研究引起了广泛的关注,然而高渗透导致的浓差极化与膜污染加剧等瓶颈问题限制了高性能膜材料的应用发展.本工作采用机器学习结合超级计算提出了针对先进反渗透膜材料的组件进水隔网(亚毫米级)与系统(米级)的多尺度优化设计新方法.在进料含盐度35,000 ppm,回收率50%典型工况下,对标目前国际先进海水反渗透淡化工艺,本文提出的优化方案能使淡水制备比能耗(1.66 k Wh/m^(3))降低27.5%,所需膜面积减少约37.2%,系统最大浓差极化因子控制在工程允许范围以内(<1.20),可有效缓解高渗透膜系统中膜污染问题,为高性能膜材料精准设计提供理论依据、计算工具和大数据支撑,有重要的应用潜力.本文提出的机器学习结合超算的多尺度设计新研究范式,突破了基于“试错法”的传统单一尺度组件设计限制,高通量并行计算规模可扩展至93,120核以上,较串行算法计算效率提升3000倍以上,可大幅度缩短高性能膜组件的设计周期.

摘要：Sodium taurocholate cotransporting polypeptide(NTCP)is identified as the functional receptor for HBV entry,which is responsible for upregulated HBV transcription in the HBV life ***,NTCP is also implicated in the progression of HBV-induced hepatocellular carcinoma(HCC).Thereby,NTCP-targeting entry inhibitors are proposed to suppress HBV infection and replication in HBV-induced hepatoma ***,we integrated in silico screening and chemical synthesis to obtain a small-molecule NTCP inhibitor B7,which exhibited moderate anti-proliferative activities against HepG2 cells and anti-HBV activity in ***,CETSA assay,molecular docking,and MD simulation validated that B7 could bind to ***,western blot analysis demonstrated that B7 induced apoptosis with an increased expression of Bax and caspase 3 cleaving as well as a decreasing expression of Bcl-2 in HepG2 *** together,our study identified B7 as a novel NTCP inhibitor with anti-proliferation activities which might provide a new opportunity for HCC therapy.

摘要：通过ZnO模板辅助的电沉积方法设计和合成了Pt管中管阵列.作为一种具有利用率高、活性物质传输快的三维结构的电催化剂,Pt管中管阵列显示了高电化学活性面积(64.9 m^2/gPt).与Pt纳米管和商业Pt/C催化剂相比,Pt管中管阵列明显提高了甲醇氧化电催化活性和稳定性.另外,Pt管中管阵列也显示了优越的抗CO毒化能力.这个研究展示了高性能Pt基直接甲醇燃料电池电催化的一个重要进展.

摘要：采用微波辅助加热乙二醇法制备了碳纳米管（CNTs）负载的PtSn双组份催化剂。采用原子吸收光谱,X射线衍射仪和电子透射显微镜对产物进行了表征。结果表明,含金属离子前驱体的乙二醇溶液的pH值对产物的金属催化剂负载量、合金化程度和PtSn粒子的形态有显著的影响。在pH值为5时能得到组分配比为原始设计值的PtSn/CNT催化剂。在pH值2~7的范围内纳米粒子的尺寸较小,随着pH值的进一步提高,纳米粒子直径变大且发生团聚。电化学测试表明在pH值为5时得到的PtSn/CNT催化剂对甲醇电化学氧化具有最佳的催化作用。合适的金属负载比例和良好的纳米颗粒形状和尺寸分布控制是得到优异的催化性能的主要原因。

摘要：Engineered Corynebacterium glutamicum was constructed for L-ornithine production by disrupting genes of argF and proB to prevent the flux away from *** of the inactivation of 2-oxoglutarate de-hydrogenase complex(ODHC) on L-ornithine production was also *** was found that the inactivation of ODHC by knockout of the kgd gene enhanced L-ornithine *** engineered *** ATCC13032(ΔargFΔproBΔkgd) produced L-ornithine up to 4.78 g·L-1 from 0.24 g·L-1 of the wild-type *** order to understand the mechanism of L-ornithine production in *** ATCC13032(ΔargFΔproBΔkgd) and find out new strategies for further enhancing L-ornithine production,the comparative proteome between the wild-type and the engineered strain was analyzed.L-Ornithine overproduction in the engineered strain was related to the up-regulation of the expression levels of enzymes involved in L-ornithine biosynthesis pathway and down-regulation of the expression levels of proteins involved in pentose phosphate *** overexpression of genes in the upstream pathway of glutamate to increase the availability of endogenous glutamate may further in-crease ornithine production in the engineered *** and the ornithine synthesis enzymes(ArgCJBD) may not be the limiting enzymes in the engineered ***.

摘要：As two promising biomaterials for bone implants,biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity;while bioceramics are known for good biocompatibility or even bioactivity but limited by their high ***,a kind of composites composing of bioceramics and biomedical metals,have been developed as an effective solution by combining their complementary *** paper focused on the recently studied biocermets for bone implant ***,biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase *** characteristics were systematically summarized,and the fabrication methods for biocermets were reviewed and *** were put on the interactions between bioceramics and biomedical metals,as well as the performance improvement *** importantly,the main methods for the interfacial reinforcing were summarized,and the corresponding interfacial reinforcing mechanisms were *** addition,the in vitro and in vivo biological performances of biocermets were also ***,future research directions were proposed on the advancement in component design,interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.