摘要：The pathogens of most infectious diseases invade the host through mucosal sites,and immunization with mucosal vaccines is the best means of combating these infectious *** delivery and nasal delivery are the most common methods of mucosal ***,the delivery process is inefficient,and mucosal vaccination is ineffective because the vaccine formulation is easily and rapidly removed and has difficulty in crossing the mucosal *** this paper,we investigated whether the mucosal immune response could be enhanced by ultrasound facilitation of nasal mucosal delivery of vaccine *** this purpose,we used manganese dioxide(MnO2)as the vaccine carrier/adjuvant,coated with chitosan oligosaccharide(COS)to enhance mucosal adsorption,and further physically adsorbed model antigen ovalbumin(OVA)to construct a nanoparticulate vaccine formulation MnO2@COS@*** treatment was found to promote antigen delivery and recruitment of dendritic cells(dCs)and macrophages as well as T-cell infiltration in nasal mucosal tissues through nasal mucosal immunization *** ultrasound assistance,MnO2@COS@OVA particles promoted the maturation of dCs in vitro and in vivo and promoted the production of effector memory T cells in vivo and cytokine secretion by splenocytes in *** particular,ultrasound treatment significantly increased the levels of secretory IgA antibodies in the nasal mucosa and genital tract mucosa of experimental *** addition,the experimental data showed that the MnO2@COS@OVA particles had good biocompatibility and caused no significant damage to the nasal mucosal and vital organ *** data suggest that ultrasound treatment can promote the induction of efficient immune responses to mucosal vaccines and provide new ideas for the opening and clinical translation of mucosal vaccines.

摘要：Personalized drugs,as well as disease-specific and condition-dependent drug release,have been highly desired in drug delivery systems for effective and safe ***-dimensional(4 d)printing,as a newly emerging technique to develop drug capsules,displays unique advantages that can autonomously control drug release according to the actual physiological ***,core-shell structured hydrogel capsules were developed using a multimaterial extrusion-based 4 d printing method,which consists of a model drug as the core and UV cross-linked poly(N-isopropylacrylamide)(PNIPAM)hydrogel as the *** to the lower critical solution temperature(LCST)-induced shrinking/swelling properties,the prepared PNIPAM hydrogel capsules showed temperature-responsive drug release along with the topography changes in the cross-linked PNIPAM *** in vitro drug release test confirmed that the PNIPAM hydrogel capsules can autonomously control their drug release behaviors according to changes in ambient ***,the increased shell thickness of these capsules causes an obvious reduction in drug release rate,distinctly indicating that the drug release behavior can be well adjusted by setting the shell thickness of the *** proposed 4 d printing strategy pioneers the paradigm of smart drug release by showing great potential in the smart controlled release of drugs and macromolecular active agents.

摘要：With more large-scale scientific computing tasks being delivered to cloud computing platforms, cloud workflow systems are designed for managing and arranging these complicated tasks. However, multi-tenant coexistence service mode of cloud computing brings serious security risks, which will threaten the normal execution of cloud workflows. To strengthen the security of cloud workflows, a mimic cloud computing task execution system for scientific workflows is proposed. The idea of mimic defense contains mainly three aspects: heterogeneity, redundancy, and dynamics. For heterogeneity, the diversities of physical servers, hypervisors, and operating systems are integrated to build a robust system framework. For redundancy, each sub-task of the workflow will be executed simultaneously by multiple executors. Considering efficiency and security, a delayed decision mechanism is proposed to check the results of task execution. For dynamics, a dynamic task scheduling mechanism is devised for switching workflow execution environment and shortening the life cycle of executors, which can confuse the adversaries and purify task executors. Experimental results show that the proposed system can effectively strengthen the security of cloud workflow execution.

摘要：With various exascale systems in different countries planned over the next three to five years, developing application software for such unprecedented computing capabilities and parallel scaling becomes a major challenge. In this study, we start our discussion with the current 125-Pflops Sunway TaihuLight system in china and its related application challenges and solutions. Based on our current experience with Sunway TaihuLight, we provide a projection into the next decade and discuss potential challenges and possible trends we would probably observe in future high performance computing software.

摘要：Taking an oxygen enriched side-blown furnace as the prototype,a hydraulic model was established according to the similarity *** influence of three factors on the gas-liquid two-phase flow was analyzed,*** airflow speed,the submerged depth and the downward angle of the nozzle.A numerical simulation of the hydraulic model was carried out trying to find the suitable turbulence model which can describe the side-blown two-phase flow correctly by comparing the simulation results with the experimental *** experiment shows that the airflow speed has a great influence on the flow of the *** submerged depth of the nozzle has a relatively smaller influence on the penetration depth and the surface fluctuation height in the liquid *** the nozzle is at a downward angle of 15°,the penetration depth and the surface fluctuation height are *** is concluded that the numerical results with the realizable k-εturbulence model are the closest to the experiment for the penetration depth,the surface fluctuation height and the bubble scale.

摘要：Artificial intelligence(AI)is the core technology of technological revolution and industrial *** one of the new intelligent needs in the AI 2.0 era,financial intelligence has elicited much attention from the academia and *** our current dynamic capital market,financial intelligence demonstrates a fast and accurate machine learning capability to handle complex data and has gradually acquired the potential to become a'financial brain.'In this paper,we survey existing studies on financial ***,we describe the concept of financial intelligence and elaborate on its position in the financial technology ***,we introduce the development of financial intelligence and review state-of-the-art techniques in wealth management,risk management,financial security,financial consulting,and ***,we propose a research framework called FinBrain and summarize four open issues,namely,explainable financial agents and causality,perception and prediction under uncertainty,risk-sensitive and robust decision-making,and multi-agent game and mechanism *** believe that these research directions can lay the foundation for the development of AI 2.0 in the finance field.

摘要：A new process of AlN removal from secondary aluminum dross(SAd)by pyrometallurgical treatment with added cryolite was applied for solving the problem of recycling the secondary aluminum *** response surface methodology(rSM)was used to design experiments and optimize *** results show that adding the appropriate amount of cryolite can effectively promote the oxidation of AlN in the SAd,and too much cryolite will reduce the promotion *** effects of roasting temperature and cryolite on the denitrification rate are the most significant(p<0.0001)followed by holding *** values of the denitrification rate are found to be in good agreement with experimental values(r^(2)=0.9894 and r_(adj)^(2)=0.9775),which confirms the validity of the model *** optimum conditions of roasting temperature of 750°C,holding time of 194 min,mass fraction of cryolite of 17.7%are obtained according to the quadratic *** these conditions,the maximum actual denitrification rate reaches 94.71%and the AlN content in the SAd is only 0.55 wt%.The unfired brick with compressive strength of 18.62 MPa(GB/T 2542−2012)was prepared based on the roasted SAd.

摘要：The one-ladle technology requires an efficient ironmaking and steelmaking interface. The scheduling of the hot metal ladle in the steel plant determines the overall operational efficiency of the interface. Considering the strong uncertainties of real-world production environments, this work studies the dynamic scheduling problem of hot metal ladles and develops a data-driven three-layer approach to solve this problem. A dynamic scheduling optimization model of the hot metal ladle operation with a minimum average turnover time as the optimization objective is also constructed. Furthermore, the intelligent perception of industrial scenes and autonomous identification of disturbances, adaptive configuration of dynamic scheduling strategies, and real-time adjustment of schedules can be realized. The upper layer generates a demand-oriented prescheduling scheme for hot metal ladles. The middle layer adaptively adjusts this scheme to obtain an executable schedule according to the actual supply–demand relationship. In the lower layer, three types of dynamic scheduling strategies are designed according to the characteristics of the dynamic disturbance in the model:real-time flexible fine-tuning, local machine adjustment, and global rescheduling. Case test using 24 h production data on a certain day during the system operation of a steel plant shows that the method and system can effectively reduce the fluctuation and operation time of the hot metal ladle and improve the stability of the ironmaking and steelmaking interface production rhythm. The data-driven dynamic scheduling strategy is feasible and effective, and the proposed method can improve the operation efficiency of hot metal ladles.

摘要：In-situ transmission electron microscopy(TEM)has been demonstrated to be a powerful method in resolving challenging problems such as interactions among various *** take advantage of the atomic resolution of advanced TEMs,a compact five-degree-of-freedom nanomanipulator was integrated with an indenter that was made of nanotwinned diamonds,for both the in-situ mechanical testing and double tilting of TEM *** a demonstration,in-situ bending tests were performed on the?111?,?110?and?100?single-crystal diamond *** tests revealed the{111}cleavage to be the dominant failure *** in-situ indentation on a diamond nanoplate led to curved cracks consisting of nanometer-scale steps,which were identified to be atomic flat{111}*** atomic-scale observation of the deformation and failure of diamonds demonstrated the stability of the entire system and the durability of the *** expect that more delicate research can be carried out by means of this holder in the near future,including in-situ stimulation,atomic characterization,and tomography.

摘要：Lithium-sulfur(Li-S)batteries are regarded as one of the most promising next-generation energy storage systems due to their high theoretical energy density and low material ***,the conventional ether-based electrolytes of Li-S batteries are extremely flammable and have high solubility of lithium polysulfides(LiPS),resulting in a high safety risk and a poor life ***,we report an ether/carbonate co-solvent fluorinated electrolyte with a special solvation sheath of Li^(+),which can prevent the formation of dissoluble long-chain LiPS of the sulfur cathode,restrict Li dendrite growth at the anode side,and show fire resistance in combustion *** a result,the proposed Li-S batteries with 70 wt%sulfur content in its cathode deliver stable life cycle,low self-discharge ratio,and intrinsic ***,the unique passivation characteristics of the designed fluorinated electrolyte break several critical limitations of the traditional“liquid phase”-based Li-S batteries,offering a facile and promising way to develop long-life and high-safety Li-S batteries.